Uroporphyrinogens

Porphyrinogens which are intermediates in heme biosynthesis. They have four acetic acid and four propionic acid side chains attached to the pyrrole rings. Uroporphyrinogen I and III are formed from polypyrryl methane in the presence of uroporphyrinogen III cosynthetase and uroporphyrin I synthetase, respectively. They can yield uroporphyrins by autooxidation or coproporphyrinogens by decarboxylation.

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Networked: 16 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ahmad, Sohaib: 1 article (06/2019)
2.	Chauhan, Payal: 1 article (06/2019)
3.	Jindal, Rashmi: 1 article (06/2019)
4.	Shirazi, Nadia: 1 article (06/2019)
5.	Bakiler, Ali Rahmi: 1 article (03/2013)
6.	Baran, Maşallah: 1 article (03/2013)
7.	Eliaçık, Kayı: 1 article (03/2013)
8.	Kanık, Ali: 1 article (03/2013)
9.	Kurt, Ismail: 1 article (03/2013)
10.	Zengin, Neslihan: 1 article (03/2013)

Related Diseases

1.	Erythropoietic Porphyria (Congenital Erythropoietic Porphyria) 01/01/2013 - "Congenital Erythropoietic Porphyria: Mutation of the Uroporphyrinogen III Cosynthase Gene in a Vietnamese Patient." 06/01/2012 - "Mutational analysis of uroporphyrinogen III cosynthase gene in Iranian families with congenital erythropoietic porphyria." 01/01/2006 - "Identification of mutations in the uroporphyrinogen III cosynthase gene in German patients with congenital erythropoietic porphyria." 03/01/2013 - "Congenital erythropoietic porphyria is a rare autosomal recessive disorder of porphyrin metabolism in which the genetic defect is the deficiency of uroporphyrinogen III cosynthase (UIIIC). " 01/01/2013 - "Congenital erythropoietic porphyria (CEP) arises from an autosomal recessive inherited disorder of the porphyrin metabolism, which leads to the accumulation of uroporphyrinogen I in bone marrow, skin and several other tissues by a deficiency of uroporphyrinogen III cosynthase (UROS). "
2.	Erythropoietic Protoporphyria 02/01/1980 - "The excretion of position isomers of type III porphyrins, not only in porphyric disorders in which the enzymatic decarboxylation of uroporphyrinogen III to coproporphyrinogen III is known to or suspected to play a role, but also in normal man and in conditions like erythropoietic protoporphyria and lead-intoxication, in which no such changes have ever been reported, or would be expected for theoretical reasons, has been described. " 12/22/1980 - "Red cell porphyrinogen carboxy-lyase activity was measured using uroporphyrinogen III as substrate in 18 normal persons, 7 male patients with porphyria cutanea tarda, 3 female patients with erythropoietic protoporphyria and 2 female patients with variegate porphyria. "
3.	Porphyria Cutanea Tarda 12/22/1980 - "Red cell porphyrinogen carboxy-lyase activity was measured using uroporphyrinogen III as substrate in 18 normal persons, 7 male patients with porphyria cutanea tarda, 3 female patients with erythropoietic protoporphyria and 2 female patients with variegate porphyria. " 05/01/1996 - "Uroporphyrinogen decarboxylase (URO-decarboxylase; EC 4.1.1.37), the heme biosynthetic enzyme responsible for the conversion of uroporphyrinogen III to coproporphyrinogen III, is the enzymatic defect in porphyria cutanea tarda, the most common porphyria. "
4.	Porphyrias (Porphyria) 06/01/2012 - "Congenital erythropoietic porphyria (CEP) is the rarest autosomal recessive porphyria resulting from a deficiency of uroporphyrinogen III cosynthase (UROS), the fourth enzyme in heme biosynthesis. " 05/01/1996 - "Uroporphyrinogen decarboxylase (URO-decarboxylase; EC 4.1.1.37), the heme biosynthetic enzyme responsible for the conversion of uroporphyrinogen III to coproporphyrinogen III, is the enzymatic defect in porphyria cutanea tarda, the most common porphyria. "
5.	Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency) 12/22/1980 - "Red cell porphyrinogen carboxy-lyase activity was measured using uroporphyrinogen III as substrate in 18 normal persons, 7 male patients with porphyria cutanea tarda, 3 female patients with erythropoietic protoporphyria and 2 female patients with variegate porphyria. "

Related Drugs and Biologics

1.	Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)
2.	Porphyrins
3.	Enzymes
4.	Heme (Haem)
5.	coproporphyrinogen III
6.	Tetrapyrroles
7.	hydroxymethylbilane
8.	Nonsense Codon (Nonsense Mutation)
9.	Uroporphyrinogen Decarboxylase (Uroporphyrinogen III Decarboxylase)
10.	Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)