Stress Urinary Incontinence

Involuntary discharge of URINE as a result of physical activities that increase abdominal pressure on the URINARY BLADDER without detrusor contraction or overdistended bladder. The subtypes are classified by the degree of leakage, descent and opening of the bladder neck and URETHRA without bladder contraction, and sphincter deficiency.

Also Known As:

Networked: 1802 relevant articles (197 outcomes, 295 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pelvic Organ Prolapse
2.	Urinary Incontinence
3.	Prolapse
4.	Overactive Urinary Bladder (Overactive Bladder)
5.	Sneezing

Experts

1.	Zhu, Lan: 22 articles (10/2014 - 01/2002)
2.	Yoshimura, Naoki: 15 articles (06/2015 - 12/2003)
3.	Chancellor, Michael B: 15 articles (02/2013 - 01/2003)
4.	Corcos, Jacques: 12 articles (05/2014 - 12/2002)
5.	Yalcin, Ilker: 12 articles (08/2007 - 07/2002)
6.	Lee, Kyu-Sung: 11 articles (01/2015 - 08/2006)
7.	Rechberger, Tomasz: 11 articles (01/2015 - 05/2002)
8.	Lang, Jing-he: 11 articles (09/2012 - 07/2003)
9.	Chartier-Kastler, Emmanuel: 10 articles (06/2015 - 12/2003)
10.	Choo, Myung-Soo: 10 articles (10/2014 - 08/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Stress Urinary Incontinence:

1.	duloxetine (Cymbalta)FDA Link 07/01/2007 - "Duloxetine has been shown to be effective in women with stress urinary incontinence (SUI). " 12/01/2009 - "Duloxetine was found safe and effective in the treatment of moderate to severe female stress urinary incontinence (SUI) in controlled clinical trials; complementary data from routine clinical practice are still wanted. " 07/01/2008 - "To assess the maintenance of efficacy of duloxetine beyond 3 months, using data from several long-term, open-label studies, as the efficacy of duloxetine 40-mg twice daily for treating women with stress urinary incontinence (SUI) for up to 3 months has been established in several randomized, placebo-controlled clinical trials. " 11/01/2005 - "The clinical efficacy of duloxetine has consistently been demonstrated in several randomized, double-blind studies in women with moderate-to-severe stress urinary incontinence, but the additional benefit relative to placebo was moderate. " 07/01/2005 - "In clinical trials in women with stress urinary incontinence, duloxetine has demonstrated efficacy in reducing incontinence episodes and increasing quality of life with no serious adverse effects. "
2.	Polypropylenes (Polypropylene)IBA 09/01/2015 - "To evaluate the safety and efficacy of a procedure using surgeon-tailored polypropylene mesh (STM) through a needle-less single-incision technique for treating stress urinary incontinence (SUI), aiming to decrease the cost of treatment, which is important in developing countries. " 09/01/1995 - "The 2-team polypropylene (Marlex) mesh approach continues to be an effective treatment for women with complicated stress urinary incontinence." 10/01/2014 - "Macroporous, monofilament polypropylene midurethral slings have been established as a safe and effective treatment for stress urinary incontinence. " 11/01/2009 - "The purpose of this study was to evaluate the safety and efficacy of a modified transobturator vaginal tape inside-out (TVT-O) procedure for stress urinary incontinence (SUI) using custom-tailored polypropylene mesh and helical needles. " 02/01/2009 - "To evaluate the efficacy of in situ anterior vaginal wall sling, reinforced with polypropylene mesh, in the treatment of stress urinary incontinence (SUI). "
3.	Serotonin (5 Hydroxytryptamine)IBA 01/01/2006 - "Insights in the role of 5-HT and NA in the neurological control of the lower urinary tract have also led to their application in common urological conditions such as stress urinary incontinence (SUI), nocturnal enuresis and ejaculatory disorders. " 08/01/2003 - "Among the drugs modulating the bladder function through 5HT receptor, duloxetine, a potent and selective inhibitor of 5-HT and NE reuptake, is presently undergoing clinical trials for stress urinary incontinence after being shown to be effective in animal models of this condition." 08/01/2010 - "Findings support the concept that combination therapy with alpha(2)-adrenoceptor antagonists may be an effective, novel strategy to reinforce the clinical efficacy of serotonin and norepinephrine reuptake inhibitors for stress urinary incontinence." 10/01/2005 - "However, recent developments have led to the first selective serotonin and noradrenaline reuptake inhibitor that has proved effective in the treatment inhibitor of stress urinary incontinence. " 11/01/2013 - "Duloxetine a serotonin reuptake inhibitor increases urethral sphincter pressure and reduce stress urinary incontinence in women and men. "
4.	Norepinephrine (Noradrenaline)FDA LinkGeneric 08/01/2015 - "Centrally acting noradrenaline reuptake inhibitor (NRI) is reportedly effective for patients with stress urinary incontinence (SUI) by increasing urethral closure in the clinical Phase IIa study with esreboxetine. " 08/01/2010 - "Findings support the concept that combination therapy with alpha(2)-adrenoceptor antagonists may be an effective, novel strategy to reinforce the clinical efficacy of serotonin and norepinephrine reuptake inhibitors for stress urinary incontinence." 10/01/2005 - "However, recent developments have led to the first selective serotonin and noradrenaline reuptake inhibitor that has proved effective in the treatment inhibitor of stress urinary incontinence. " 06/15/2010 - "New N-(1,2-diphenylethyl)piperazines 6 are disclosed as dual serotonin and noradrenaline reuptake inhibitors (SNRI) which may have potential in treating stress urinary incontinence (SUI). " 01/01/2005 - "Serotonin and noradrenaline reuptake inhibitors (SNRI) for stress urinary incontinence in adults."
5.	CollagenIBA 01/01/2002 - "Transurethral collagen injection is both safe and effective when used for the treatment of genuine stress urinary incontinence. " 03/01/1998 - "Periurethral collagen injection has been advocated as a safe and effective method of treatment for stress urinary incontinence. " 06/01/2007 - "Clinical trials have demonstrated the safety and efficacy of non-surgical, transurethral radiofrequency (RF) collagen denaturation for treating female stress urinary incontinence (SUI) due to hypermobility. " 11/01/2010 - "To evaluate 18-month safety and durability of efficacy of nonsurgical transurethral collagen denaturation as treatment for stress urinary incontinence (SUI) in women. " 01/01/2009 - "To assess efficacy of nonsurgical transurethral collagen denaturation (Renessa) in women with stress urinary incontinence (SUI) caused by bladder outlet hypermobility. "
6.	baysilon (polydimethylsiloxane)IBA 02/01/2009 - "A study was carried out to evaluate efficacy of Macroplastique(R) (MPQ) Implantation System (MIS) in women with urodynamic stress urinary incontinence (SUI) and urethral hypermobility after an unsuccessful conservative treatment. " 03/01/2014 - "We investigated the efficacy of transurethral injection of Macroplastique bulking agent (Uroplasty) for male stress urinary incontinence (SUI) after prostate surgery. " 05/01/1989 - "Between September 1, 1985 and December 31, 1987, 54 patients with stress urinary incontinence were treated with a reinforced silastic sling using an abdominovaginal approach; 42 patients were cured, two improved and nine were the same or worse. " 01/01/2013 - "This study critically assessed the safety and effectiveness outcomes for adult women treated with Macroplastique for stress urinary incontinence (SUI) through a systematic review and meta-analysis. " 04/01/2010 - "We evaluated the durability of the urethral bulking agent Macroplastique for stress urinary incontinence in a 24-month study in women with a previously documented successful outcome 12 months after the last injection. "
7.	Estrogens (Estrogen)FDA Link 01/01/2015 - "One study reported an improvement in stress urinary incontinence with use of vaginal estrogen. " 10/01/2004 - "[Study on estrogen receptor around levator ani muscle for female stress urinary incontinence]." 09/01/2004 - "Our study is to investigate the presence of estrogen receptor (ER) and its possible etiological relationship with the development of stress urinary incontinence (SUI). " 08/01/1986 - "These findings are discussed in light of conflicting human studies regarding objective evidence for the role of hormonal modulation of urethral function and the role of estrogen therapy for stress urinary incontinence." 10/01/2015 - "The roles of estrogen receptor α (ERα) in stress urinary incontinence (SUI) remain elusive. "
8.	salicylhydroxamic acid (SHAM)IBA 01/01/2015 - "We report a protocol of a multicenter, randomized, double-blind, sham-controlled parallel-group trial to evaluate the efficacy of magnetic stimulation for stress urinary incontinence. " 05/01/2009 - "To compare the efficacy of extracorporeal electromagnetic stimulation (ES) of the pelvic floor for treating stress urinary incontinence (SUI) vs sham ES. " 01/01/2015 - "There is currently a lack of randomized, sham-controlled trials that are adequately powered, using validated outcomes, to allow for firm recommendations on the use of magnetic stimulation for stress urinary incontinence. " 05/01/2007 - "Safety and efficacy have been demonstrated in several studies, including a 12-month, multicenter, sham-procedure-controlled clinical trial in 173 women with mild-to-moderate stress urinary incontinence. " 01/01/2015 - "One hundred twenty subjects with stress urinary incontinence will be randomized in a 1:1 allocation to either active or sham magnetic stimulation using computer-generated, permuted blocks of variable sizes. "
9.	SiliconesIBA 12/01/2002 - "In our experience, periurethral silicone injection was a safe treatment for female stress urinary incontinence and provided a moderately successful and durable therapeutic effect in those with sphincter deficiency and good anatomic support. " 11/01/2003 - "Randomized clinical trials, using valid and reliable subjective and objective measurements, are necessary to establish the efficacy of silicone microimplants therapy in treating stress urinary incontinence in adult women." 11/01/2003 - "A computer-aided and manual search for published studies investigating silicone microimplants therapy for stress urinary incontinence in adult women. " 12/01/2002 - "A total of 29 female patients with stress urinary incontinence underwent endoscopic periurethral silicone injection. " 12/01/2002 - "To evaluate periurethral silicone injection in the treatment of female stress urinary incontinence due to intrinsic sphincter deficiency (ISD) and assess whether coexisting urethral hypermobility has an impact on treatment outcome. "
10.	BulkamidIBA 11/01/2012 - "Bulkamid is a periurethral bulking agent used to treat stress urinary incontinence (SUI). " 09/01/2014 - "Bulkamid is a new, simple, office based bulking system that shows promise as a treatment in women with stress urinary incontinence, particularly since Contigen is no longer commercially available." 09/01/2014 - "We evaluated the safety and efficacy of Bulkamid vs Contigen® collagen gel for stress urinary incontinence or stress predominant mixed urinary incontinence. " 06/01/2014 - "This study was carried out to evaluate the efficacy of periurethral injection of polyacrylamide hydrogel (PAHG, Bulkamid(®), Ethicon) for the treatment of female stress urinary incontinence (SUI). " 07/01/2013 - "To investigate the effectiveness and safety of periurethral injections (PIs) of polyacrylamide hydrogel (PAHG, Bulkamid(®)) for the treatment of female stress urinary incontinence (SUI). "

Therapies and Procedures

1.	Suburethral Slings (Tension-Free Vaginal Tape) 03/01/2011 - "The MONARC transobturator suburethral sling is a safe and highly effective treatment for stress urinary incontinence even in women with low MUCP at a mean follow-up of 48 months. " 06/01/2009 - "In the last few years, the Burch colposuspension and the fascial slings were often defined from the pages of the most relevant journals of general medicine, as gold-standard procedures for the surgical treatment of stress urinary incontinence (SUI), whereas mid-urethral slings (tension-free vaginal tape (TVT) and tension-free vaginal tape obturator) were attributed a marginal and almost experimental role in this field. " 04/01/2001 - "The tension-free vaginal tape operation is an effective and safe procedure for treatment of most cases of female urinary stress incontinence. " 11/01/2004 - "Surgical treatment of female stress urinary incontinence has become very popular as a consequence of the good results given by the minimally invasive tension-free vaginal tape. " 09/01/2004 - "The management of female stress urinary incontinence has been markedly improved by the suprapubic tension-free vaginal tape (TVT) and transobturator tape techniques. "
2.	Prostatectomy (Retropubic Prostatectomy) 04/01/2011 - "We report on our initial data from a prospective study to determine the efficacy of high-frequency magnetic stimulation on the sacral root (MSSR) for the intractable post-radical prostatectomy, stress urinary incontinence (SUI). " 01/01/1997 - "Urinary stress incontinence after radical prostatectomy could be cured by physiotherapy in a high percentage. " 09/01/2005 - "The promising results reported here suggest that this may be an appropriate, effective and durable first-line treatment to offer men with stress urinary incontinence after prostatectomy." 07/01/2013 - "Implantation of male transobturator AdVance sling is effective and safe treatment for patients with stress urinary incontinence after radical prostatectomy." 06/01/1995 - "Pelvic floor exercises has been found useful in the treatment of post radical perineal prostatectomy stress urinary incontinence."
3.	Artificial Urinary Sphincter 08/01/2007 - "Significant improvement and high patient satisfaction are seen after artificial urinary sphincter implantation for male stress urinary incontinence. " 09/01/2006 - "To perform a preliminary clinical investigation to determine the safety and efficacy of a novel artificial urinary sphincter (AUS) with conditional occlusion for the treatment of stress urinary incontinence. " 01/01/2015 - "Artificial urinary sphincter is currently considered the "gold standard" treatment of male stress urinary incontinence. " 04/01/2013 - "To assess retrospectively the safety and efficacy of an artificial urinary sphincter, the ZSI 375 device (Zephyr Surgical Implants, Geneva, Switzerland), in male patients with moderate-to-severe stress urinary incontinence after a prostate or bladder intervention. " 04/01/2013 - "The artificial urinary sphincter (AUS) has historically been considered the gold standard for the surgical management of non-neurogenic stress urinary incontinence (SUI) in men. "
4.	Injections 08/01/2014 - "The purpose of our study was to find out whether transurethral injections of autologous adipose stem cells (ASCs) are an effective and a safe treatment for female stress urinary incontinence (SUI). " 04/01/2005 - "To determine the efficacy of endoscopical injections for the treatment of stress urinary incontinence (SUI), evaluating its low invasiveness and positive impact on quality of life. " 06/01/2011 - "In this study, the growth factor-immobilized porous beads were investigated for their potential use as an injectable urethral bulking agent for the treatment of stress urinary incontinence (SUI). " 06/01/2008 - "We hereby report a 1-year follow-up on eight women in the first North America trial in which stress urinary incontinence (SUI) was treated with muscle-derived stem cell injections. " 02/01/2015 - "Local injections of mesenchymal, muscle-derived, and adipose-derived stem cells have all yielded successful outcomes in animal models of mechanical, nerve, or external urethral sphincter injury in stress urinary incontinence. "
5.	Psychology Biofeedback (Biofeedback) 07/01/2001 - "Four weeks of both intensive group physical therapy or individual biofeedback training followed by an unsupervised home exercise program for 2 mo are effective therapies for female urinary stress incontinence and result in a significantly reduced nocturnal urinary frequency and improved subjective outcome. " 01/01/1998 - "Efficacy of biofeedback in the treatment of urinary stress incontinence." 06/01/1992 - "A group of 36 patients (18 premenopausal and 18 postmenopausal), all suffering from genuine stress urinary incontinence, underwent conservative treatment with 6 sessions of intravaginal electromyostimulation followed by 6 sessions of biofeedback; 89% of patients reported an improvement, 5.5% considered themselves cured and 5.5% reported no change. " 10/01/2013 - "The aim of this study was to evaluate the results of conservative treatment of urodynamic stress urinary incontinence (SUI) using transvaginal electrical stimulation with surface-electromyography-assisted biofeedback (TVES + sEMG) in women of premenopausal age. " 05/31/2008 - "This study was performed in order to compare the effects of interferential current and biofeedback applications on incontinence severity in patients with urinary stress incontinence. "