Uridine Diphosphate Glucose Dehydrogenase

An enzyme that catalyzes the oxidation of UDPglucose to UDPglucuronate in the presence of NAD+. EC 1.1.1.22.

Also Known As:

Dehydrogenase, UDP Glucose; Dehydrogenase, UDPG; Glucose Dehydrogenase, UDP; UDP Glucose Dehydrogenase; UDPG Dehydrogenase; UDPglucose:NAD+ 6-oxidoreductase

Networked: 18 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - Carbohydrate Dehydrogenases
        Uridine Diphosphate Glucose Dehydrogenase: 18
        Arabidopsis UGD1 protein
        C elegans SQV-4 protein
        E coli KfiD protein
        human UGDH protein
        Streptococcus pneumoniae Cap3a protein

Experts

1.	Simpson, Melanie A: 2 articles (09/2021 - 01/2010)
2.	Barycki, Joseph J: 1 article (09/2021)
3.	Corey, Eva: 1 article (09/2021)
4.	Enders, Jeffrey R: 1 article (09/2021)
5.	Howell, Michelle E: 1 article (09/2021)
6.	Lehman, Danielle: 1 article (09/2021)
7.	Ma, Linlin: 1 article (09/2021)
8.	Zimmer, Brenna M: 1 article (09/2021)
9.	Alaniz, Laura: 1 article (01/2021)
10.	Caon, Ilaria: 1 article (01/2021)

Related Diseases

1.	Osteoarthritis 12/03/2014 - "The objective of this study was to investigate the possible role of UDP-glucose dehydrogenase (UGDH) in osteoarthritis (OA) and uncover whether, furthermore how interleukin-1beta (IL-1β) affects UGDH gene expression. " 12/03/2014 - "UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis."
2.	Chordoma 10/01/1990 - "Enzyme histochemical study revealed that a sacrococcygeal chordoma not only was rich in oxidoreductive enzymes but also in the enzymes (phosphorylase, hexokinase, phosphoglucomutase, glucose phosphate isomerase and UDP-glucose dehydrogenase) leading to the synthesis of stromal glycosaminoglycans from glycogen. "
3.	Neoplasms (Cancer) 01/01/2023 - "UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology." 10/19/2023 - "A top hit was the cancer-associated, proteoglycan subunit synthesis enzyme UDP-glucose dehydrogenase (UGDH). " 03/22/2023 - "Nevertheless, the phosphorylation of tyrosine 473 (Y473) of UDP-glucose dehydrogenase (UGDH is capable of converting UDP-Glc to uridine diphosphate glucuronic acid (UDP-GlcUA)) weakens the inhibition of UDP-Glc to HuR, thus initiating the epithelial-mesenchymal transformation of tumor cells and promoting tumor cell migration and metastasis. "
4.	Prostatic Neoplasms (Prostate Cancer) 01/15/2010 - "Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer." 09/14/2021 - "UDP-glucose dehydrogenase (UGDH) produces UDP-glucuronate, the essential precursor for glucuronidation, and its expression is elevated in prostate cancer. " 01/15/2010 - "Uridine diphosphate (UDP)-glucose dehydrogenase (UGDH) catalyzes the oxidation of UDP-glucose to yield UDP-glucuronic acid, a precursor for synthesis of glycosaminoglycans and proteoglycans that promote aggressive prostate cancer (PC) progression. "
5.	Neoplasm Metastasis (Metastasis) 10/01/2020 - "Targeting UDP-glucose dehydrogenase inhibits ovarian cancer growth and metastasis." 03/22/2023 - "Nevertheless, the phosphorylation of tyrosine 473 (Y473) of UDP-glucose dehydrogenase (UGDH is capable of converting UDP-Glc to uridine diphosphate glucuronic acid (UDP-GlcUA)) weakens the inhibition of UDP-Glc to HuR, thus initiating the epithelial-mesenchymal transformation of tumor cells and promoting tumor cell migration and metastasis. "

Related Drugs and Biologics

1.	Glycosaminoglycans
2.	Phosphorylases (Glucan Phosphorylase)
3.	Glycogen
4.	Enzymes
5.	Interleukin-1beta (Interleukin 1 beta)
6.	Phosphoglucomutase
7.	Phosphates (Orthophosphate)
8.	Isomerases
9.	Hexokinase
10.	Glucose (Dextrose)