Uridine

11/01/2006 - "Delaying the administration of the combination of PTAU plus uridine to 4 h post FUra treatment was less effective in rescuing from FUra toxicity as only 88% of the mice survived and tumor weights were reduced by only 62%. "
01/01/2015 - "TKI interactions with human nucleoside transporters (hNT) were studied by assessing inhibition of [(3)H]uridine uptake in yeast producing recombinant hNTs individually and in cultured human cancer cell lines. "
06/01/2012 - "Alternatively, the combination of PTAU and uridine may be useful as an antidote in the few cases when cancer patients receive a lethal overdose of FUra."
06/01/2012 - "The efficiency of the PTAU plus uridine combination can be attributed to the extraordinary effectiveness of this combination treatment in raising and maintaining higher levels of uridine in vivo (Al Safarjalani et al. in Cancer Chemo Pharmacol 55:541-551, 2005). "
09/01/2011 - "Uridine-based paramagnetic supramolecular nanoaggregate with high relaxivity capable of detecting primitive liver tumor lesions."

05/01/2013 - "We assessed the safety and efficacy of sofosbuvir, a uridine nucleotide analogue, in treatment-naive patients with genotype 1-3 HCV infection. "
04/01/2010 - "The increased cytokine production with the uridine-bulge design resulted in enhanced protection against Semliki Forest virus (SFV) infection, in viral assays. "
04/01/2013 - "Insect bioassays revealed that the ΔBbura3 strain was essentially avirulent using both topical and intrahemocoel injection assays, indicating that the deletion mutant was unable to scavenge uridine from the host during infection. "
05/01/2010 - "In contrast to poliovirus infection, the incorporation of BrUTP, fluorouridine and [14C]uridine in rRNA precursors was observed even during the late stages of mengovirus infection, although at a significantly reduced level. "
01/01/2010 - "HIV-1 infection is associated with a decrease in plasma uridine and a shift of uridine to the adipose tissue compartment. "

10/01/2010 - "The protective effects of uridine were independent of myeloid dendritic cell (mDC) function, because in vitro pre-treatment of allergen-pulsed DCs with uridine did not alter the degree of inflammation. "
10/01/2010 - "In this study, we investigated the influence of uridine on asthmatic airway inflammation. "
01/01/2015 - "Further, uridine is a small, inexpensive molecule and may thus be a new therapeutic option to treat joint inflammation in RA."
10/01/2010 - "In summary, we were able to show that uridine inhibits the classical features of asthmatic airway inflammation. "
10/01/2010 - "Local administration of uridine suppresses the cardinal features of asthmatic airway inflammation."

10/01/2010 - "Is uridine a treatment for asthma?"
10/01/2010 - "As uridine supplementation is well tolerated in humans, it might be a new therapeutic approach for the treatment of bronchial asthma."
10/01/2010 - "Uridine was also effective in reducing airway inflammation in HDM-induced asthma. "
08/01/2007 - "The aim of this study was to investigate whether uridine has any anti-inflammatory properties in an asthma-like animal model of lung inflammation. "

01/01/1981 - "In convalescence, uridine-to-uracil ratios and FA studies of buffy coat normalized, indicating clearance of M. "