Uricosuric Agents

01/01/2022 - "Uricosuric agents are the typical approach to the control of hyperuricemia; however, their use has been eclipsed by adverse reactions, and a safer uricosuric drug is badly needed. "
09/15/2021 - "Therefore, URAT1 inhibitors are considered to be a highly effective and promising class of uricosuric agents for treating hyperuricemia. "
12/01/1996 - "Treatments of complications as well as those of hyperuricemia with uricosuric agents are required for clinical treatment of gouty patients."
01/10/1976 - "[Uricosuric agents: Should they be used in asymptomatic hyperuricemia?]."
01/01/2023 - "3. The present findings will provide further comprehensive insight into the treatment value of certain uricosuric agents for gout or hyperuricemia."

08/01/1961 - "Uricosuric agents in the management of chronic tophaceous gout with renal impairment."
01/01/2022 - "What is the Place for Uricosuric Agents in Gout Management?"
01/01/2018 - "Co-administration of a XOI and an uricosuric agent should be considered for patients with high sUA first in the treatment algorithm of gout before uptitration of XOI. "
11/14/2014 - "Uricosuric agents have long been used in the treatment of gout but there is little evidence regarding their benefit and safety in this condition. "
09/01/2002 - "A combination of spot urine Ua/Cr and spot urine Scr*Ua/Cr may be clinically useful in selecting gout patients with 24 Ua/S below 2.84 mmol/m2 for treatment with uricosuric agents without adverse effects."

01/01/2020 - "The effect of uricosuric agents on the decrease in hospitalized stroke risk indicated a dose-response relationship. "
01/01/2020 - "Subgroup analyses revealed that uricosuric agents and xanthine oxidase inhibitors were significantly associated with lower risks of hospitalized stroke and all-cause mortality, respectively. "
01/01/2020 - "Among the urate-lowering therapy, subgroup analyses indicated that uricosuric agents had a significant effect on the prevention of CAD and stroke development; and the protection against the development of CAD by uricosuric agents appeared to have a dose-response trend. "
01/02/2022 - "Considering the increased prevalence of stroke in the population with gout, the aim of this study was to evaluate the effects of benzbromarone, a uricosuric agent, on the incidence of stroke in the population with gout. "

08/01/1980 - "Renal handling of urate in healthy man in hyperuricaemia and renal insufficiency: circadian fluctuation, effect of water diuresis and of uricosuric agents."
05/01/1995 - "Uricosuric agents can cause renal lithiasis and/or acute renal failure in patients with renal failure and/or high urinary levels of uric acid. "
07/01/1996 - "These data suggest that the tubular secretion of urate is selectively impaired in FJGN and at the stage of renal failure, the combination of an uricosuric agent with allopurinol might be effective in treating hyperuricemia in FJGN."
09/01/1987 - "Thus, we concluded that allantoxanamide might be a useful reagent for investigating the causes of hyperuricemia with renal failure, but was not a practical agent like oxonate in order to evaluate the response to uricosuric agents."

01/01/2013 - "Probenecid, a prototypical uricosuric agent and chemical inhibitor of organic anion transporters known to target OAT3, was shown to be effective in limiting influenza A virus infection in vitro (50% inhibitory concentration [IC(50)] of 5.0 × 10(-5) to 5.0 × 10(-4) μM; P < 0.005) and in vivo (P < 0.05). "