Urethane (Ethyl Carbamate)

01/01/2011 - "In addition, we report a significant reduction in lung tumor number and size after urethane exposure or genetic activation of oncogenic Kras in Mmp10 null (Mmp10(-/-)) mice. "
10/01/1998 - "In mice treated with three different doses of urethan and fed NAC in the diet, a significant reduction in lung tumor multiplicity was found only at one dose level. "
12/01/2011 - "Continued sTNFR:Fc administration was effective in halting both respiratory tumor formation and progression in response to urethane. "
04/01/1986 - "The shortest duration of O2 exposure to be effective was 4 wk, and delay of O2 exposure up to 12 wk after urethan still was effective in reducing the number of developing tumors. "
03/01/1988 - "Therefore, impairment of the normal immunological functions of skin resulted from treatment with the tumor promotor TPA but not the tumor initiator urethane, which suggests that a loss of LC during tumor promotion may impair immunological protection against skin tumors."

08/01/1977 - "As shown, the AF doses eliminating the primary action of urethane on the mechanical properties of the tissue significantly decreased the incidence of adenomas. "
01/01/2011 - "It was also found effective against urethane induced lung-adenoma in mice. "
12/10/1998 - "Our recent linkage study of urethane-induced pulmonary adenomas in SMXA RI strains of mouse revealed two host resistance genes, Par1 (chromosome 11) and Par3 (chromosome 12). "
06/01/1987 - "The effect of lead on urethan-induced pulmonary adenoma formation was evaluated in the 105 day study. "
10/01/1973 - "Urethan-induced pulmonary adenoma as a tool for the study of surfactant biosynthesis."

09/01/1967 - "[Studies on the increasing effects of hypoxia tolerance in the kidney treated with urethane derivatives]."
01/01/2014 - "To begin to address this issue, we examined diaphragm EMG activity in response to and at 5-min intervals for 60 min following three 5-min episodes of hypoxia (8% O2) in urethane-anesthetized spontaneously breathing P14-P15 neonatal rats (n=15). "
01/01/2014 - "Intermittent hypoxia-induced respiratory long-term facilitation is dominated by enhanced burst frequency, not amplitude, in spontaneously breathing urethane-anesthetized neonatal rats."
04/01/2012 - "Urethane anesthetized, paralyzed, unilaterally vagotomized, and artificially ventilated adult male Sprague-Dawley rats were subjected to 10 exposures of hypoxia (10% O(2) in N(2), 45 s, separated by 5 min, n = 7). "
01/01/2012 - "Transient cerebral ischaemia/hypoxia was induced in 30 male Wistar rats by bilateral common carotid artery clamping for 15 min and concomitant ventilation with 6% O2 during general anaesthesia with urethane. "

01/01/1992 - "4. Furthermore, they did not antagonize AA (4 nmol kg-1)-induced hypotension in urethane-anaesthetized rats. "
09/01/1991 - "Furthermore, pretreatment of rats with the two drugs (T 11 and P 175 mu mole kg-1 for 30 min) significantly antagonised AA (4 n mole kg-1)-induced hypotension in urethane-anaesthetised rats. "
05/01/1988 - "As in urethane-anesthetized dogs, i.v. Prop elicited remarkable HR reduction accompanied by progressive hypotension in coronary-ligated rats with high sympathetic activity. "
04/01/1988 - "At 30 min after placement of the lesions, severe hypotension (MAP = 54 +/- 5 mm Hg) persisted in the rats anesthetized with urethane. "
01/01/1987 - "In mice anaesthetized with urethane, Paf (1-30 micrograms kg-1) produced hypotension which was not clearly dose-related. "

09/01/2007 - "Heat stroke was induced by exposing urethane-anaesthetised animals to a temperature of 43 degrees C for 55 min, which caused the body temperature to reach 42 degrees C. "
09/01/2005 - "2. Urethane-anaesthetized rats were exposed to heat stress (ambient temperature 43 degrees C) to induce heat stroke. "
09/01/2005 - "Urethane-anesthetized rats were exposed to heat stress (43 degrees C) to induce heatstroke. "
06/01/2005 - "Urethane-anesthetized animals were exposed to an ambient temperature of 43 degrees C to induce heatstroke. "
05/01/2005 - "Urethane-anesthetized rats were exposed to heat stress (ambient temperature of 43 degrees C) to induce heat stroke. "