Ureteral Obstruction

Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.

Also Known As:

Networked: 1692 relevant articles (105 outcomes, 185 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Fibrosis (Cirrhosis)
2.	Inflammation
3.	Neoplasms (Cancer)
4.	Hydronephrosis
5.	Renal Insufficiency (Renal Failure)

Experts

1.	Nørregaard, Rikke: 18 articles (12/2015 - 08/2005)
2.	Frøkiaer, Jørgen: 18 articles (06/2014 - 07/2002)
3.	Nielsen, Søren: 16 articles (04/2010 - 05/2003)
4.	Liu, Youhua: 14 articles (12/2015 - 01/2002)
5.	Meldrum, Kirstan K: 12 articles (10/2013 - 10/2004)
6.	Felsen, Diane: 12 articles (09/2010 - 01/2003)
7.	Chen, Jie: 11 articles (09/2010 - 02/2004)
8.	Li, Chunling: 10 articles (04/2015 - 05/2003)
9.	Eddy, Allison A: 10 articles (01/2014 - 05/2003)
10.	Knepper, Mark A: 10 articles (07/2011 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ureteral Obstruction:

1.	Transforming Growth Factor beta (TGF-beta)IBA 12/01/2000 - "Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction." 06/01/1994 - "In this study, we delineated the kinetics of renal cortical macrophage infiltration as well as the cortical expression of transforming growth factor-beta 1 (TGF-beta 1) and monocyte chemoattractant peptide-1 (MCP-1) at 12, 48, and 96 h after unilateral ureteral obstruction (UUO). " 08/01/2008 - "[Expression of p27 and TGF-beta in rat kidney with unilateral ureteral obstruction and the relationship between TGF-beta and p27]." 12/01/2005 - "Elevated plasma concentrations of transforming growth factor-beta 1 in patients with unilateral ureteral obstruction." 08/01/2001 - "To investigate whether partial ureteral obstruction (PUO) in the fetus induces dysregulation of the renin-angiotensin system (RAS) and of transforming growth factor-beta 1 (TGF-beta1) and tissue inhibitors of metalloproteinase (TIMP1) expression. "
2.	atorvastatin (Lipitor)FDA Link 12/01/2004 - "Atorvastatin ameliorates renal tissue damage in unilateral ureteral obstruction." 04/01/2010 - "To examine the effects of atorvastatin on renal hemodynamics and urinary microalbumin levels in rats with acute unilateral ureteral obstruction (UUO). " 04/01/2010 - "Atorvastatin protects renal function in the rat with acute unilateral ureteral obstruction." 12/01/2007 - "[Effects of atorvastatin on expression of peroxisome proliferation activated receptor gamma in unilateral ureteral obstruction in rats]." 02/01/2007 - "In rats with 12-day unilateral ureteral obstruction the glomerular filtration rate but not effective renal plasma flow was significantly higher and urinary microalbumin was significantly lower in atorvastatin treated rats than in those without atorvastatin treatment. "
3.	aliskirenFDA Link 04/15/2015 - "Aliskiren restores renal AQP2 expression during unilateral ureteral obstruction by inhibiting the inflammasome." 08/01/2011 - "Aliskiren has anti-inflammatory and antifibrotic effects in an experimental unilateral ureteral obstruction mouse model." 08/01/2011 - "Aliskiren ameliorates renal inflammation and fibrosis induced by unilateral ureteral obstruction in mice." 08/01/2011 - "Thus, we evaluated whether inhibiting the renin-angiotensin system by aliskiren would decrease renal inflammation and fibrosis in a mouse model of unilateral ureteral obstruction. " 04/15/2015 - "In conclusions, RAS blockade with the direct renin inhibitor aliskiren increased water channel AQP2 expression in obstructed kidneys of UUO mice, at least partially by preventing NLRP3 inflammasome activation in association with ureteral obstruction. "
4.	salicylhydroxamic acid (SHAM)IBA 09/01/2012 - "In the present study, subgroups of rats were subjected to unilateral ureteral obstruction (UUO) or sham operation and observed for 24h to 3 months. " 11/01/2007 - "To study the pathogenesis of nephropathy, a variable-partial, complete or a sham unilateral ureteral obstruction (UUO) was produced in mice within 2 days of birth. " 04/01/2007 - "To study this, male Sprague-Dawley rats were subjected to left unilateral ureteral obstruction vs. sham operation. " 04/01/2006 - "To study this, male Sprague Dawley rats were subjected to 3 days of unilateral ureteral obstruction (UUO) versus sham operation. " 02/01/2005 - "To study this, male Sprague-Dawley rats were subjected to left unilateral ureteral obstruction vs. sham operation. "
5.	Succimer (Dimercaptosuccinic Acid)FDA Link 09/01/1988 - "Phosphorus-31 magnetic resonance (MR) spectroscopy was used to study the effects of partial and complete ureteral obstruction on the porcine kidney; results were compared with renal tubular function as determined with technetium-99m dimercaptosuccinic acid (DMSA) scintigraphy. " 09/01/1988 - "Complete and partial ureteral obstruction: evaluation of renal effects with P-31 MR spectroscopy and Tc-DMSA scintigraphy." 04/01/1999 - "The aim of this longitudinal study was to evaluate tubular proteinuria in rats with unilateral (UPO) and bilateral (BPO) partial ureteral obstruction with the dimercaptosuccinic acid (DMSA) scan as the gold standard for measuring renal tubular damage. " 08/01/1995 - "With recent evidence that DMSA differential function may be a better predictor of outcome following relief of unilateral ureteral obstruction consideration should be given to using DMSA as a potentially more relevant method for differential function measurement in the setting of unilateral hydronephrosis. " 01/01/1985 - "To evaluate this possible divergence, we measured the relative GFR (I-125 iothalamate), ERPF (I-131 hippurate), and Tc-99m DMSA accumulation in adult male Sprague-Dawley rats with unilateral ureteral obstruction or unilateral ischemia at various times after renal injury. "
6.	urinastatin (MR 20)IBA 02/01/2013 - "This study aims to explore the protective effects and mechanisms of ulinastatin (UTI), which is a urinary trypsin inhibitor, of the renal interstitial fibrosis of rats subjected to unilateral ureteral obstruction (UUO). " 09/01/2014 - "The aim of the present study was to examine the protective effects of the urinary trypsin inhibitor ulinastatin (UTI) on renal interstitial inflammation and fibrosis in rats subjected to unilateral ureteral obstruction (UUO). " 09/01/2014 - "Ulinastatin attenuates renal interstitial inflammation and inhibits fibrosis progression in rats under unilateral ureteral obstruction." 02/01/2013 - "Ulinastatin inhibits unilateral ureteral obstruction-induced renal interstitial fibrosis in rats via transforming growth factor β (TGF-β)/Smad signalling pathways."
7.	CreatinineIBA 07/01/1986 - "At subsequent presentation with deteriorating renal function, ureteral obstruction was evident and was relieved with percutaneous antegrade balloon dilatation with a return of his plasma creatinine to normal. " 09/01/2015 - "To determine the respective associations between ureteral obstruction and renomegaly, urine specific gravity (USG), and serum creatinine concentration and to assess the reliability of abdominal palpation for detection of renomegaly in cats. " 09/01/2015 - "Respective associations between ureteral obstruction and renomegaly, urine specific gravity, and serum creatinine concentration in cats: 29 cases (2006-2013)." 07/01/2015 - "The relative contribution of urine extravasation to elevate plasma creatinine levels in acute unilateral ureteral obstruction." 06/01/2011 - "In total, two (10.5%) patients developed increasing creatinine levels postoperatively as a result of distal ureteral obstruction, and temporary urinary drainage was necessary in both patients. "
8.	Pregnenolone Carbonitrile (PCN)IBA 01/01/2010 - "The goal of the study was to evaluate the outcome and complications after percutaneous nephrostomy (PCN) insertion in advanced and terminal-stage gynecological malignancies with ureteral obstruction (UO). " 01/01/2015 - "To preserve renal function, patients with bilateral malignant ureteral obstruction, especially those aged 55 or more or with diabetes or poor baseline renal function, should be considered for early PCN conversion in the dominant functional kidney or both." 05/01/2013 - "We used multivariable analysis to compare those with ureteral obstruction treated with RUS or PCN to those not treated and to analyze the association between RUS, PCN, and survival. " 01/01/2012 - "Due to complete ureteral obstruction, the "Y" extension with the valve was connected to PCN and to the urinary bag, which enabled the patient to perform intermittent self-irrigation. " 04/01/2010 - "A total forty (40) patients fulfilled the criteria for initial PCN placement for their malignant ureteral obstruction. "
9.	TamoxifenFDA LinkGeneric 08/01/2008 - "At 6 months, therapy with tamoxifen determined the retroperitoneal fibrotic mass regression and resolved the ureteral obstruction, that persists at the 13th month of follow-up. " 11/01/2014 - "In this study, we investigated the protective effects of tamoxifen on unilateral ureteral obstruction (UUO)-induced renal tubulointerstitial fibrosis and its molecular mechanism. " 07/01/2005 - "Despite therapy with sulindac and tamoxifen, both suffered progressive ureteral obstruction that required initial percutaneous drainage. " 01/01/2015 - "We report the promising results achieved in a case of neuroendocrine tumor complicated by retroperitoneal fibrosis causing right ureteral obstruction treated with long-acting release octreotide and tamoxifen. " 01/01/2007 - "Comparison of the effects of captopril, tamoxifen and L-carnitine on renal structure and fibrosis after total unilateral ureteral obstruction in the rat."
10.	tranilast (N 5')IBA 05/01/2001 - "Tranilast ameliorates renal tubular damage in unilateral ureteral obstruction." 05/01/2001 - "This finding suggests that tranilast is a promising agent for preventing renal tubular damage in unilateral ureteral obstruction." 05/01/2001 - "Tranilast (150 mg./kg.) was administered to rats 1 day before unilateral ureteral obstruction and each day thereafter. " 11/01/1992 - "In 23 patients (30 ureters), self-expanding metal stents were implanted endoscopically (n = 23), percutaneously (n = 5), or bidirectionally (n = 2) because of extrinsic malignant ureteral obstruction. " 01/01/2010 - "This study evaluated the efficacy of tranilast to attenuate renal fibrosis induced by unilateral ureteral obstruction (UUO) in rats in relation to epithelial-mesenchymal transition (EMT) and peritubular capillary injury. "

Therapies and Procedures

1.	Stents 01/01/2009 - "The significantly higher forces required to compress the Resonance and Silhouette stents may translate into improved success in patients with malignant ureteral obstruction." 09/01/1996 - "Measures including induced delivery, amniocentesis, and insertion of ureteral stents or nephrostomy tubes undertaken to relieve the ureteral obstruction usually lead to rapid improvement in urine flow and renal function. " 08/01/2014 - "Stent placement appeared to be a valuable and safe option for treating ureteral obstruction in cats. " 04/01/2014 - "Covered metallic stent placement for malignant ureteral obstruction is superior to the double J stent placement in terms of technical success and patency." 07/01/2013 - "Ureteral stents are effective for relief of ureteral obstruction by ureteroliths in both dogs and cats. "
2.	Drug Therapy (Chemotherapy) 10/01/2010 - "Pronostic variables included in the study are clinical stage, grade of differentiation, presence of ureteral obstruction, chemotherapy modality, radiotherapy doses and p53 and ki-67 expression. " 05/01/2011 - "The prognosis of ureteral obstruction secondary to gastric cancer was extremely poor, particularly when chemotherapy was not administered. " 08/01/2012 - "Ureteral obstruction due to testicular tumor was relieved after chemotherapy or retroperitoneal lymph node dissection. " 02/01/1984 - "The problems of ureteral obstruction are quickly eliminated, even if the tumor has not been removed by chemotherapy, radiotherapy, or surgery. " 10/01/2008 - "Placement of double-J stent or nephrostomy tube represents the classical procedures performed in a renal colic due to acute ureteral obstruction when the conservative drug therapy does not resolve the symptoms. "
3.	Transplantation (Transplant Recipients) 07/01/1997 - "All patients with early (n = 13) ureteral obstruction (< 3 months after transplantation), had improved renal function (P < .025). " 12/01/2014 - "Case report of a ureteral obstruction by Candida albicans fungus balls detected by magnetic resonance imaging in kidney transplant recipient." 03/01/2010 - "Ureteral obstruction following transplantation is not uncommon. " 06/01/2005 - "An unusual cause of ureteral obstruction in a renal transplant recipient: ureteric aspergilloma." 02/15/2001 - "Ureteral obstruction in the transplant recipient can provide a diagnostic challenge. "
4.	Urinary Diversion (Ileal Conduit) 09/01/1999 - "To assess the efficacy of urinary diversion (internal v external) in the management of ureteral obstruction secondary to pelvic malignancies and the patients' quality of life after diversion. " 08/01/2010 - "To describe our experiences with nephrocutaneous bypass and to assess the role of this procedure as a mean of urinary diversion in patients with incurable ureteral obstruction who are not appropriate candidates for subcutaneous pyelovesical bypass. " 08/01/2008 - "We identified patients with ureteral obstruction likely to benefit from palliative urinary diversion so that they can be advised appropriately. " 08/01/2008 - "Prognostic model for predicting survival after palliative urinary diversion for ureteral obstruction: analysis of 140 cases." 08/01/2007 - "Management of extrinsic malignant ureteral obstruction with urinary diversion."
5.	Nephrectomy 12/01/1984 - "Neonatal guinea pigs with chronic partial ureteral obstruction (CPUO) and contralateral nephrectomy develop hydroureteronephrosis and reduced glomerular filtration rate (GFR) without significant reduction of renal blood flow. " 01/01/2015 - "Surgery is the treatment of choice to remove endometriotic lesions and relieve ureteral obstruction if the kidney is still functional or a nephrectomy is performed if there is a complete loss of renal function. " 11/01/2013 - "Surgery is the treatment of choice to remove endometriotic lesions and relieve ureteral obstruction if the kidney is still functional, or to perform a nephrectomy if there is a complete loss of renal function." 08/01/2013 - "In the other three, the ureteral obstruction appeared gradually and was detected by ultrasound scans and MAG3 diuretic renogram; one underwent nephrectomy because of poor renal function, and the other two were treated with endoscopic dilatation of the UVJ. " 11/01/2007 - "We measured these modifications of plasma protein and related free adducts in plasma following bilateral nephrectomy and bilateral ureteral obstruction. "