Glucuronosyltransferase (UDP Glucuronosyltransferase)

A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC
Also Known As:
UDP Glucuronosyltransferase; 17 beta-Hydroxysteroid UDP-Glucuronosyltransferase; 4-Nitrophenol-UDP-Glucuronosyltransferase; 7-Hydroxycoumarin UDP Glucuronyltransferase; Androsterone UDP-Glucuronosyltransferase; Bilirubin UDP-Glucuronyltransferase; Estrogen UDP-Glucuronosyltransferase; Estrone Glucuronyltransferase; Glucuronic Transferase; Morphine Glucuronyltransferase; UDP Glucuronyl Transferase; UDP-Glucuronic Acid 3-O-beta-D-Galactosyl-D-Galactose Glucuronosyltransferase; p-Nitrophenyl UDP-Glucuronosyltransferase; 17 beta Hydroxysteroid UDP Glucuronosyltransferase; 4 Nitrophenol UDP Glucuronosyltransferase; 7 Hydroxycoumarin UDP Glucuronyltransferase; Androsterone UDP Glucuronosyltransferase; Bilirubin UDP Glucuronyltransferase; Estrogen UDP Glucuronosyltransferase; Glucuronosyltransferase, UDP; Glucuronyl Transferase, UDP; Glucuronyltransferase, 7-Hydroxycoumarin UDP; Glucuronyltransferase, Estrone; Glucuronyltransferase, Morphine; Transferase, Glucuronic; Transferase, UDP Glucuronyl; UDP Glucuronic Acid 3 O beta D Galactosyl D Galactose Glucuronosyltransferase; UDP Glucuronyltransferase, 7-Hydroxycoumarin; UDP-Glucuronosyltransferase, 17 beta-Hydroxysteroid; UDP-Glucuronosyltransferase, Androsterone; UDP-Glucuronosyltransferase, Estrogen; UDP-Glucuronosyltransferase, p-Nitrophenyl; UDP-Glucuronyltransferase, Bilirubin; p Nitrophenyl UDP Glucuronosyltransferase; Glucuronyltransferase; UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
Networked: 447 relevant articles (8 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Guillemette, Chantal: 7 articles (02/2015 - 05/2002)
2. Lazarus, Philip: 7 articles (12/2012 - 08/2003)
3. Mackenzie, Peter I: 6 articles (06/2015 - 03/2004)
4. Hu, Dong Gui: 5 articles (06/2015 - 08/2009)
5. Huang, Ching-Shan: 5 articles (08/2014 - 08/2005)
6. Yamamoto, Wataru: 5 articles (01/2012 - 02/2006)
7. Sasaki, Yasutsuna: 5 articles (01/2012 - 02/2006)
8. Araki, Kazuhiro: 5 articles (01/2012 - 02/2006)
9. Fujita, Ken-ichi: 5 articles (01/2012 - 02/2006)
10. Nagashima, Fumio: 5 articles (01/2012 - 02/2006)

Related Diseases

1. Neoplasms (Cancer)
2. Lymphoma (Lymphomas)
01/01/1996 - "In an attempt to confirm the efficacy of D3 as an antineoplastic agent, the present investigation aims at characterizing the importance of D3 in modulating hepatic drug metabolizing enzymes, namely, cytosolic glutathione S-transferase (GSHT), microsomal UDP glucuronyl transferase (UDPGT), and cytochrome P-450, which have been reported by us in recent literature as significant neoplastic markers in mice bearing Dalton's lymphoma (DL). "
01/01/1993 - "The potentiating effect of vanadium was supported by biochemical analysis of autopsies relating to markers like microsomal cytochrome P-450, UDP glucuronyl transferase (UDPGT) and cytosolic glutathione-S-transferase (GSHT) in the hepatic tissue of the hosts, which showed substantial alterations in the extent of tumor regression as compared to their lymphoma and normal counterparts, prolonging the survival of the hosts."
02/01/2015 - "Japanese clinical practice guidelines indicate that some clinical biomarkers, such as epidermal growth factor receptor gene mutations, echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion gene and uridine diphosphate glucuronosyltransferase genotypes should be determined in appropriate lung cancer patients. "
01/01/2015 - "The uridine diphosphate glucuronosyltransferase (UGT) gene 1A1*6 polymorphism, which affects irinotecan metabolism, has been associated with improved survival in lymphoma patients treated with of carboplatin, dexamethasone, etoposide and irinotecan (CDE-11). "
3. Sickle Cell Anemia (Hemoglobin S Disease)
4. Small Cell Lung Carcinoma (Small Cell Lung Cancer)
5. Jaundice

Related Drugs and Biologics

1. Uridine Diphosphate (UDP)
2. Enzymes
3. irinotecan (Camptosar)
4. Cytochrome P-450 Enzyme System (Cytochrome P450)
5. Glutathione Transferase (Glutathione S-Transferase)
6. Carcinogens
7. Bilirubin
8. Morphine (MS Contin)
9. Aniline Hydroxylase
10. Etoposide (VP 16)

Related Therapies and Procedures

1. Combination Drug Therapy (Combination Chemotherapy)
2. Drug Therapy (Chemotherapy)
3. Transplantation (Transplant Recipients)
4. Hepatectomy
5. Transplants (Transplant)