Ubiquitins

A family of proteins that are structurally-related to Ubiquitin. Ubiquitins and ubiquitin-like proteins participate in diverse cellular functions, such as protein degradation and HEAT-SHOCK RESPONSE, by conjugation to other proteins.

Also Known As:

Networked: 125 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Leifeng: 5 articles (05/2022 - 01/2016)
2.	Knobeloch, Klaus-Peter: 5 articles (10/2021 - 08/2005)
3.	Wang, Hongmin: 5 articles (02/2020 - 01/2017)
4.	Shao, Jianghua: 4 articles (01/2021 - 09/2014)
5.	Feng, Shelley: 4 articles (02/2020 - 01/2017)
6.	Liu, Yanying: 4 articles (02/2020 - 01/2017)
7.	Qiao, Fangfang: 4 articles (01/2020 - 01/2017)
8.	Liu, Xiuxia: 4 articles (01/2018 - 09/2014)
9.	Wang, Kai: 3 articles (05/2022 - 09/2014)
10.	Yu, Xin: 3 articles (05/2022 - 09/2014)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 09/15/2014 - "The ubiquitin-like protein FAT10 and the homeobox protein HOXB9 each promote metastatic progression in hepatocellular carcinoma (HCC). " 06/15/2023 - "The ubiquitin-like protein FAT10 in hepatocellular carcinoma cells limits the efficacy of anti-VEGF therapy by accelerating VEGF-independent angiogenesis." 09/15/2014 - "Ubiquitin-like protein FAT10 promotes the invasion and metastasis of hepatocellular carcinoma by modifying β-catenin degradation." 01/01/2008 - "Here we describe in detail a SYBR GreenI-based assay using the LightCycler instrument to measure the levels of mRNA for the ubiquitin-like protein FAT10 relative to 18S rRNA in human hepatocellular carcinoma tissue. " 06/15/2023 - "To investigate the effects and mechanisms of human leukocyte antigen F locus-adjacent transcript 10 (FAT10), a ubiquitin-like protein, in limiting the efficacy of anti-VEGF therapy in hepatocellular carcinoma (HCC) cells. "
2.	Neoplasms (Cancer) 01/01/2022 - "Previous studies have proposed ubiquitin-like protein FAT10 plays key roles in the initiation and progression of several types of human cancer, but little is known about the interrelation between FAT10 gene expression, tumor immunity, and prognosis of patients with SKCM. " 11/01/2020 - "Ubiquitin-like protein FAT10: A potential cardioprotective factor and novel therapeutic target in cancer." 01/01/2020 - "Here, we found that the level of FAT10, a ubiquitin-like protein, was significantly higher in tumors than in adjacent normal tissues. " 01/01/2020 - "In many types of cancers, FAT10, a ubiquitin-like protein, is involved in several biological activities, especially cell proliferation. " 01/01/2019 - "Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. "
3.	Virus Diseases (Viral Diseases) 10/01/2019 - "Human UBL4A/GdX, encoding an ubiquitin-like protein, was shown in this study to be upregulated by viral infection and IFN stimulation. " 12/22/2020 - "After a viral infection, one of the genes activated by IFN induction is the IFN-stimulated gene 15 (ISG15), which encodes a ubiquitin-like protein that undergoes a reversible posttranslational modification (ISGylation). " 03/11/2008 - "ISG15 is an IFN-inducible, ubiquitin-like protein expressed after bacterial or viral infection. " 12/21/2022 - "Ubiquitin and related ubiquitin-like proteins (Ubls) influence a variety of cellular pathways including protein degradation and response to viral infections. " 12/01/2022 - "Interferon Stimulated Gene (ISG)15 is a ubiquitin-like protein that is induced upon viral infections. "
4.	Breast Neoplasms (Breast Cancer) 07/01/2012 - "In the present study, we investigated the role of UHRF1 (ubiquitin-like protein containing PHD and RING finger domains 1) in proliferation, invasion and migration of breast cancer cells, and the potential mechanisms were also explored. " 01/01/2007 - "Ubiquitin-like protein modifications in prostate and breast cancer." 01/01/2017 - "The ubiquitin-fold modifier 1 (UFM1)-system, a ubiquitin-like protein conjugation system, is involved in the development of breast cancer and several hereditary neurological syndromes. " 02/01/2013 - "Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer." 02/01/2013 - "This paper will discuss ubiquitin and ubiquitin-like proteins conjugating enzymes participating in breast cancer pathogenesis, their relationships with other proteins of the ubiquitination machinery and their role in phenotype of breast cancer sub-types."
5.	Bites and Stings (Sting) 12/01/2023 - "Ubiquitination is extensively involved in antiviral signaling, and recent studies suggest that ubiquitin-like proteins (Ubls) modifications also participate in innate antiviral pathways such as RLR and cGAS-STING pathways. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	HLA Antigens (Human Leukocyte Antigens)
3.	Ubiquitin
4.	Proteasome Endopeptidase Complex (Proteasome)
5.	Antiviral Agents (Antivirals)
6.	Proteins (Proteins, Gene)
7.	Interferons
8.	Enzymes
9.	Adenosine Triphosphatases (ATPase)
10.	Ubiquitin-Conjugating Enzymes

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy