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Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)

A multisubunit enzyme complex that contains CYTOCHROME B GROUP; CYTOCHROME C1; and iron-sulfur centers. It catalyzes the oxidation of ubiquinol to UBIQUINONE, and transfers the electrons to CYTOCHROME C. In MITOCHONDRIA the redox reaction is coupled to the transport of PROTONS across the inner mitochondrial membrane.
Also Known As:
Coenzyme Q-Cytochrome-c Reductase; Complex III; Coenzyme QH2-Cytochrome-c Reductase; Core I Protein, UCCreductase; Core I Protein, Ubiquinol-Cytochrome c Reductase; Core II Protein, UCCreductase; Core II Protein, Ubiquinol-Cytochrome c Reductase; Cytochrome b-c2 Oxidoreductase; Cytochrome bc1; Dihydroubiquinone-Cytochrome-c Reductase; QH(2)-Cytochrome-c Reductase; QH(2)-Ferricytochrome-c Oxidoreductase; Ubihydroquinone-Cytochrome-c Reductase; Ubiquinol-Cytochrome c Reductase; Ubiquinone-Cytochrome b-c2 Oxidoreductase; Coenzyme Q Cytochrome c Reductase; Coenzyme QH2 Cytochrome c Reductase; Core I Protein, Ubiquinol Cytochrome c Reductase; Core II Protein, Ubiquinol Cytochrome c Reductase; Cytochrome b c2 Oxidoreductase; Dihydroubiquinone Cytochrome c Reductase; Reductase, Ubiquinol-Cytochrome c; Ubihydroquinone Cytochrome c Reductase; Ubiquinol Cytochrome c Reductase; Ubiquinone Cytochrome b c2 Oxidoreductase; Cytochrome bc1 Complex; Ubiquinol-Cytochrome-c Reductase; Ubiquinol-ferricytochrome-c oxidoreductase
Networked: 458 relevant articles (14 outcomes, 43 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Fellman, Vineta: 11 articles (01/2020 - 10/2002)
2. Chandel, Navdeep S: 9 articles (11/2020 - 06/2007)
3. Lesnefsky, Edward J: 8 articles (07/2014 - 01/2002)
4. Kotarsky, Heike: 7 articles (01/2020 - 08/2010)
5. Schumacker, Paul T: 7 articles (01/2018 - 03/2002)
6. Hoppel, Charles L: 7 articles (11/2009 - 01/2002)
7. Kwon, Ho Jeong: 6 articles (04/2022 - 04/2010)
8. Feichtinger, René G: 6 articles (12/2021 - 04/2015)
9. Zeviani, Massimo: 6 articles (10/2021 - 05/2007)
10. Mayr, Johannes A: 5 articles (12/2021 - 04/2015)

Related Diseases

1. Mitochondrial Diseases (Mitochondrial Disease)
2. Echinococcosis (Hydatid Cysts)
3. Toxoplasmosis
4. Hypoxia (Hypoxemia)
5. Sepsis (Septicemia)
03/01/2016 - "Moreover, sepsis triggers complex III (CIII)-linked alterations in supercomplexes structure, and loss of mitochondrial density. "
02/01/2016 - "Future studies will identify specific renal proteins within complex III that are modified during sepsis to provide mechanistic insight on how mitochondrial respiration is inhibited during sepsis."
04/01/2016 - "Improved survival in metformin-treated septic mice was correlated with preservation of mitochondrial complex V (ATP synthase) function and increased amounts of ETC complex III and IV. Although immunosuppression is a consequence of sepsis, metformin effectively increased innate immune capacity to eradicate P. "
12/01/2014 - "Polymicrobial sepsis induced mitochondrial dysfunction in leukocytes, as demonstrated by increased H2O2 and mitochondrial O2- production (CLP vs. sham; H2O2: 3,173±498, n=5 vs. 557±38, n=4; O2-: 707±66, n=35 vs. 485±35, n=17, mean fluorescence intensity, mean±SEM), attenuated complex III activity (13±2, n=16 vs. 30±3, n=7, millioptical densities/min), loss of mitochondrial ΔΨm, and depletion of intracellular ATP (33±6, n=11 vs. 296±29, n=4, nmol/mg protein). "
06/01/2004 - "However, it is not known whether these abnormalities are the result of a specific mitochondrial alteration, decreased pyruvate dehydrogenase (PDH) complex activity, depletion of ubiquinone (CoQ(10); electron donor for the mitochondrial complex III), or all 3. In this study we sought to specify metabolism disturbances in a murine model of sepsis, using either a PDH-activator infusion (dichloroacetate, DCA) or CoQ(10) supplementation. "

Related Drugs and Biologics

1. Atovaquone (Mepron)
2. Ubiquinone
3. oligomycin sensitivity-conferring protein (complex V)
4. Adenosine Triphosphate (ATP)
5. ubiquinol
6. telacebec
7. Metformin (Glucophage)
8. Toll-Like Receptors (Toll-Like Receptor)
9. Leu Transfer RNA
10. Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)

Related Therapies and Procedures

1. Radiotherapy
2. Therapeutics
3. Cochlear Implantation
4. Liver Transplantation
5. Drug Therapy (Chemotherapy)