Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)

A multisubunit enzyme complex that contains CYTOCHROME B GROUP; CYTOCHROME C1; and iron-sulfur centers. It catalyzes the oxidation of ubiquinol to UBIQUINONE, and transfers the electrons to CYTOCHROME C. In MITOCHONDRIA the redox reaction is coupled to the transport of PROTONS across the inner mitochondrial membrane.
Also Known As:
Coenzyme Q-Cytochrome-c Reductase; Complex III; Bacterial Electron Transport Complex III; Coenzyme QH2-Cytochrome-c Reductase; Core I Protein, UCCreductase; Core I Protein, Ubiquinol-Cytochrome c Reductase; Core II Protein, UCCreductase; Core II Protein, Ubiquinol-Cytochrome c Reductase; Cytochrome b-c2 Oxidoreductase; Cytochrome bc1; Dihydroubiquinone-Cytochrome-c Reductase; Mitochondrial Electron Transport Complex III; QH(2)-Cytochrome-c Reductase; QH(2)-Ferricytochrome-c Oxidoreductase; Ubihydroquinone-Cytochrome-c Reductase; Ubiquinol-Cytochrome c Reductase; Ubiquinone-Cytochrome b-c2 Oxidoreductase; Coenzyme Q Cytochrome c Reductase; Coenzyme QH2 Cytochrome c Reductase; Core I Protein, Ubiquinol Cytochrome c Reductase; Core II Protein, Ubiquinol Cytochrome c Reductase; Cytochrome b c2 Oxidoreductase; Dihydroubiquinone Cytochrome c Reductase; Reductase, Ubiquinol-Cytochrome c; Ubihydroquinone Cytochrome c Reductase; Ubiquinol Cytochrome c Reductase; Ubiquinone Cytochrome b c2 Oxidoreductase; Cytochrome bc1 Complex; Ubiquinol-Cytochrome-c Reductase; Ubiquinol-ferricytochrome-c oxidoreductase
Networked: 237 relevant articles (3 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Lesnefsky, Edward J: 7 articles (09/2012 - 01/2002)
2. Chandel, Navdeep S: 7 articles (01/2012 - 06/2007)
3. Schumacker, Paul T: 6 articles (02/2013 - 03/2002)
4. Hoppel, Charles L: 6 articles (06/2009 - 01/2002)
5. Kwon, Ho Jeong: 4 articles (10/2014 - 04/2010)
6. Jung, Hye Jin: 4 articles (10/2014 - 04/2010)
7. Rustin, Pierre: 4 articles (08/2013 - 07/2003)
8. Guzy, Robert D: 4 articles (02/2013 - 06/2005)
9. Moraes, Carlos T: 4 articles (12/2012 - 04/2007)
10. Fellman, Vineta: 4 articles (01/2012 - 11/2002)

Related Diseases

1. Mitochondrial Diseases (Mitochondrial Disease)
2. Lactic Acidosis
3. Mitochondrial Encephalomyopathies (Mitochondrial Encephalomyopathy)
02/01/2009 - "Infantile mitochondrial encephalomyopathy with unusual phenotype caused by a novel BCS1L mutation in an isolated complex III-deficient patient."
12/01/2000 - "Mitochondrial encephalomyopathy and complex III deficiency associated with a stop-codon mutation in the cytochrome b gene."
01/01/1993 - "The levels of mitochondrial electron transport system proteins cytochrome c oxidase (COX) and complex III were measured in muscle fibers of patients with mitochondrial encephalomyopathy using quantitative immunoelectron microscopy. "
05/15/2009 - "We found that the PGC-1alpha and/or PGC-1beta expression improved mitochondrial respiration in cells harboring a complex III or IV deficiency as well as in transmitochondrial cybrids harboring mitochondrial encephalomyopathy lactic acidosis and stroke A3243G tRNA((Leu)UUR) gene mutation. "
08/01/2011 - "General conclusions are that: (i) disorders of glycogen metabolism are more likely to cause 'fetal disease' than defects of the respiratory chain; (ii) mitochondrial encephalomyopathies, especially those due to defects of the nuclear genome, are frequent causes of neonatal or infantile diseases, typically Leigh syndrome, but usually do not cause fetal distress; (iii) notable exceptions include mutations in the complex III assembly gene BCS1L resulting in the GRACILE syndrome (growth retardation, aminoaciduria, cholestasis, iron overload, lactic acidosis, and early death), and defects of mitochondrial protein synthesis, which are the 'new frontier' in mitochondrial translational research."
4. Lung Injury
5. Stroke (Strokes)

Related Drugs and Biologics

1. Toll-Like Receptors (Toll-Like Receptor)
2. Leu Transfer RNA
3. Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)
4. Reactive Oxygen Species (Oxygen Radicals)
5. Proteins (Proteins, Gene)
6. Oxidoreductases
7. coenzyme Q10 (CoQ10)
8. oligomycin sensitivity-conferring protein (complex V)
9. Carrier Proteins (Binding Protein)
10. Cytochromes b (Cytochrome b)

Related Therapies and Procedures

1. Cochlear Implantation
2. Liver Transplantation
3. Heterologous Transplantation (Xenotransplantation)