Tyrosine-tRNA Ligase

An enzyme that activates tyrosine with its specific transfer RNA. EC 6.1.1.1.

Also Known As:

Tyr-tRNA Ligase; Tyrosyl-tRNA Synthetase; Ligase, Tyr-tRNA; Ligase, Tyrosine-tRNA; Synthetase, Tyrosyl-tRNA; Tyr tRNA Ligase; Tyrosine tRNA Ligase; Tyrosyl tRNA Synthetase; Tyrosyl T RNA Synthetase; L-Tyrosine:tRNA-(Tyr) ligase (AMP-forming)

Networked: 27 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Ligases: 5553
    - Carbon-Oxygen Ligases
      - Amino Acyl-tRNA Synthetases: 433
        Tyrosine-tRNA Ligase: 27
        human mini-TyrRS

Experts

1.	Guan, Min-Xin: 3 articles (01/2021 - 02/2016)
2.	Liu, Rui: 3 articles (02/2016 - 07/2010)
3.	Qiang, Ou: 3 articles (02/2016 - 07/2010)
4.	Zeng, Rui: 3 articles (02/2016 - 07/2010)
5.	Zeng, Zhi: 3 articles (02/2016 - 07/2010)
6.	Ji, Yanchun: 2 articles (01/2021 - 02/2016)
7.	Jiang, Pingping: 2 articles (01/2021 - 02/2016)
8.	Jin, Xiaofen: 2 articles (01/2021 - 02/2016)
9.	Yi, Qiuzi: 2 articles (01/2021 - 12/2019)
10.	Zhang, Juanjuan: 2 articles (01/2021 - 02/2016)

Related Diseases

1.	Myocardial Infarction 02/01/2016 - "The purpose of this study was to clarify the effect of mini-tyrosyl-tRNA synthetase/mini-tryptophanyl-tRNA synthetase (mini-TyrRS/mini-TrpRS) in ischemic angiogenesis in rhesus monkeys with acute myocardial infarction (AMI). " 01/01/2011 - "The purpose of this study was to determine the mechanism of mini-tyrosyl-tRNA synthetase/mini-tryptophanyl-tRNA synthetase (mini-TyrRS/mini-TrpRS) on ischemic angiogenesis in rats with acute myocardial infarction and proliferation, migration, potential signaling pathways of rat coronary venular endothelial cells (RCVECs). " 02/01/2016 - "Effect of Mini-Tyrosyl-tRNA Synthetase/Mini-Tryptophanyl-tRNA Synthetase on Angiogenesis in Rhesus Monkeys after Acute Myocardial Infarction." 07/01/2010 - "We aimed to clarify the different angiogenesis effects of mini-tyrosyl-tRNA synthetase (TyrRS)/minitryptophanyl-tRNA synthetase (TrpRS) in rodent primates with acute myocardial infarction, by delivering small interfering RNAs (siRNAs) systemically in a liposomal formulation. "
2.	Thrombocytopenia (Thrombopenia) 01/01/2018 - "Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia." 09/05/2014 - "In this study, we examined the therapeutic effect of recombinant human tyrosyl-tRNA synthetase (rhTyrRS) against development of thrombocytopenia in cyclophosphamide (CTX) treated mice. "
3.	Colorectal Neoplasms (Colorectal Cancer) 12/31/2022 - "In the present study, we evaluated transcript levels of mitochondrial tyrosyl-tRNA synthetase YARS2 in both colorectal cancer tissues and normal colorectal tissues using qRT-PCR. " 12/31/2022 - "Targeting mitochondrial tyrosyl-tRNA synthetase YARS2 suppresses colorectal cancer progression."
4.	Muscular Diseases (Myopathy) 12/17/2013 - "Mutations in the mitochondrial tyrosyl-tRNA synthetase (YARS2) gene have previously been identified as a cause of the tissue specific mitochondrial respiratory chain (RC) disorder, Myopathy, Lactic Acidosis, Sideroblastic Anaemia (MLASA). " 08/05/2021 - "Pathogenic variants in the mitochondrial tyrosyl-tRNA synthetase gene (YARS2) were associated with myopathy, lactic acidosis, and sideroblastic anemia (MLASA). " 04/01/2014 - "Biallelic mutations in the YARS2 gene encoding mitochondrial tyrosyl-tRNA synthetase cause myopathy, lactic acidosis, and sideroblastic anemia 2 (MLASA2), a type of mitochondrial disease. " 08/01/2012 - "Here, we report a novel missense mutation (c.137G>A, p.Gly46Asp) in the catalytic domain of YARS2, which codes for the mitochondrial tyrosyl-tRNA synthetase, in a subject with myopathy, lactic acidosis, and sideroblastic anemia (MLASA). " 07/09/2010 - "Mutation of the mitochondrial tyrosyl-tRNA synthetase gene, YARS2, causes myopathy, lactic acidosis, and sideroblastic anemia--MLASA syndrome."
5.	Lactic Acidosis 12/17/2013 - "Mutations in the mitochondrial tyrosyl-tRNA synthetase (YARS2) gene have previously been identified as a cause of the tissue specific mitochondrial respiratory chain (RC) disorder, Myopathy, Lactic Acidosis, Sideroblastic Anaemia (MLASA). " 08/05/2021 - "Pathogenic variants in the mitochondrial tyrosyl-tRNA synthetase gene (YARS2) were associated with myopathy, lactic acidosis, and sideroblastic anemia (MLASA). " 04/01/2014 - "Biallelic mutations in the YARS2 gene encoding mitochondrial tyrosyl-tRNA synthetase cause myopathy, lactic acidosis, and sideroblastic anemia 2 (MLASA2), a type of mitochondrial disease. " 08/01/2012 - "Here, we report a novel missense mutation (c.137G>A, p.Gly46Asp) in the catalytic domain of YARS2, which codes for the mitochondrial tyrosyl-tRNA synthetase, in a subject with myopathy, lactic acidosis, and sideroblastic anemia (MLASA). " 07/09/2010 - "Mutation of the mitochondrial tyrosyl-tRNA synthetase gene, YARS2, causes myopathy, lactic acidosis, and sideroblastic anemia--MLASA syndrome."

Related Drugs and Biologics

1.	Tryptophan-tRNA Ligase
2.	Therapeutic Uses
3.	Cyclophosphamide (Cytoxan)
4.	Transfer RNA (tRNA)
5.	Ligases (Synthetase)
6.	Enzymes
7.	Serine C-Palmitoyltransferase
8.	Angiogenesis Inducing Agents (Angiogenesis Factor)
9.	Matrix Metalloproteinase 1 (Interstitial Collagenase)
10.	Cytokines