Tyrosine Transaminase (Tyrosine Aminotransferase)

An enzyme that catalyzes the conversion of L-TYROSINE and 2-oxoglutarate to 4-hydroxyphenylpyruvate and L-GLUTAMATE. It is a pyridoxal-phosphate protein. L-PHENYLALANINE is hydroxylated to L-tyrosine. The mitochondrial enzyme may be identical with ASPARTATE AMINOTRANSFERASES (EC 2.6.1.1.). Deficiency of this enzyme may cause type II Tyrosinemia (see TYROSINEMIAS). EC 2.6.1.5.

Also Known As:

Networked: 306 relevant articles (0 outcomes, 17 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Carvalho-Silva, Milena: 8 articles (01/2020 - 08/2013)
2.	Streck, Emilio L: 8 articles (01/2020 - 08/2013)
3.	Ferreira, Gustavo C: 7 articles (01/2019 - 08/2013)
4.	Scaini, Giselli: 6 articles (01/2020 - 01/2014)
5.	Gomes, Lara M: 5 articles (01/2020 - 01/2017)
6.	Schuck, Patrícia F: 5 articles (11/2018 - 08/2013)
7.	Schuck, Patricia F: 3 articles (01/2020 - 01/2017)
8.	Ferreira, Gabriela K: 3 articles (01/2014 - 08/2013)
9.	de Oliveira, Jade: 2 articles (01/2020 - 01/2019)
10.	Dal-Pizzol, Felipe: 2 articles (01/2019 - 12/2013)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/1980 - "Studies on the different molecular forms of tyrosine aminotransferase from rat liver and hepatoma cells." 02/10/1971 - "Studies on the degradation of tyrosine aminotransferase in hepatoma cells in culture. " 05/01/2010 - "Down-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma." 06/01/2002 - "Moreover, in rat hepatoma H4-II-E cells, the esterified-BM failed to induce tyrosine aminotransferase, which is regulated by GR-mediated transactivation activity. " 01/01/1998 - "When a rat hepatoma cell line H4-II-E-C3, which retains the induction of tyrosine aminotransferase (TAT), was co-cultured in a monolayer with NPLCs, dose-dependent stimulation of TAT induction was observed. "
2.	Tyrosinemias (Tyrosinemia) 12/05/2022 - "Tyrosinemia type II and III are autosomal recessive disorders caused by pathogenic variants in the tyrosine aminotransferase (TAT), and 4-hydroxyphenyl-pyruvate dioxygenas (HPPD) genes, respectively. " 11/30/2022 - "BACKGROUND Tyrosinemia Type II (TYRII) is a rare autosomal recessive inborn error of metabolism caused by deficiency of tyrosine aminotransferase (TAT), leading to hypertyrosinemia. " 01/01/2017 - "Tyrosinemia type II is a rare autosomal recessive disease caused by deficiency of hepatic tyrosine aminotransferase and is associated with neurologic and development difficulties in numerous patients. " 10/01/2016 - "Tyrosinemia type II is a rare autosomal recessive disorder caused by deficiency of tyrosine aminotransferase (TAT). " 01/01/2014 - "Mutations in the tyrosine aminotransferase gene have been identified to cause tyrosinemia type II which is inherited in an autosomal recessive manner. "
3.	Experimental Liver Neoplasms 01/01/1970 - "Further studies on the induction of tyrosine aminotransferase in Morris hepatoma 9618A." 03/01/1991 - "[Differences in expression and functional organization of the rat tyrosine aminotransferase gene in two lines of Morris hepatoma, 8994 and 7777]." 01/01/1978 - "Expression of hormonally induced tyrosine aminotransferase in host liver and Morris hepatoma No. 7777 during cofactor depletion." 03/01/1988 - "[Regulation of the transcription of the tyrosine aminotransferase gene by glucocorticoids in Morris hepatoma 7777 and 8994 cells]." 04/01/1985 - "The transfer of Morris hepatoma cells induced by the hormone within 10-60 min in to a hormone-free medium is associated with the augmentation of tyrosine aminotransferase synthesis. "
4.	Starvation 02/01/1996 - "The activity of tyrosine aminotransferase significantly increased in the period between days 2 and 5 of starvation, after which a decrease to the level of satiated animals was observed in the terminal period. " 04/20/1983 - "The post-weaning increase in hepatic tyrosine aminotransferase of obese rats was only observed during the light phase of the diurnal cycle, but was prevented by pair-feeding and by starvation. " 01/03/1980 - "The tyrosine aminotransferase rhythm persisted even under starvation, though the amplitude decreased remarkably. " 01/01/2008 - "Here, we study a cycle of long-term starvation followed by refeeding in relation to the kinetics of serine dehydratase (SerDH) and tyrosine aminotransferase (TyrAT) in rainbow trout (Oncorhynchus mykiss). " 01/01/2008 - "Serine dehydratase and tyrosine aminotransferase activities increased by long-term starvation and recovery by refeeding in rainbow trout (Oncorhynchus mykiss)."
5.	Photophobia (Light Sensitivity) 05/01/2011 - "In the present study we report the clinical features and the molecular genetic investigation of the tyrosine aminotransferase (TAT) gene in a young girl from Croatia with Richner-Hanhart syndrome, mainly suffering from photophobia, hyperkeratosis of the palmes and soles and slight neurological abnormalities. " 11/01/2011 - "A girl, born to unrelated Spanish parents, presented at 6 months of age with photophobia, keratitis, palmar hyperkeratosis and high plasma tyrosine levels, indicative of tyrosinaemia type II. Analysis of the tyrosine aminotransferase (TAT) gene revealed a paternally inherited frameshift mutation c.1213delCinsAG at codon 405 causing a premature stop codon, and a maternally inherited deletion of 193kb encompassing the complete TAT gene and three neighbouring genes. "

Related Drugs and Biologics

1.	Enzymes
2.	Glucocorticoids
3.	L-Serine Dehydratase (Serine Dehydratase)
4.	Dexamethasone (Maxidex)
5.	Steroids
6.	Insulin (Novolin)
7.	Phosphoenolpyruvate
8.	Amino Acids
9.	RNA (Ribonucleic Acid)
10.	Albumins

Related Therapies and Procedures

1.	Adrenalectomy
2.	Protein-Restricted Diet (Diet, Protein Restricted)
3.	Intraperitoneal Injections
4.	Injections