Tyrosine Transaminase (Tyrosine Aminotransferase)

An enzyme that catalyzes the conversion of L-TYROSINE and 2-oxoglutarate to 4-hydroxyphenylpyruvate and L-GLUTAMATE. It is a pyridoxal-phosphate protein. L-PHENYLALANINE is hydroxylated to L-tyrosine. The mitochondrial enzyme may be identical with ASPARTATE AMINOTRANSFERASES (EC 2.6.1.1.). Deficiency of this enzyme may cause type II Tyrosinemia (see TYROSINEMIAS). EC 2.6.1.5.

Also Known As:

Networked: 259 relevant articles (0 outcomes, 15 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ferreira, Gabriela K: 3 articles (01/2014 - 08/2013)
2.	Schuck, Patrícia F: 3 articles (01/2014 - 08/2013)
3.	Streck, Emilio L: 3 articles (01/2014 - 08/2013)
4.	Ferreira, Gustavo C: 3 articles (01/2014 - 08/2013)
5.	Carvalho-Silva, Milena: 3 articles (01/2014 - 08/2013)
6.	Vieira, Júlia S: 2 articles (01/2014 - 12/2013)
7.	Dutra-Filho, Carlos Severo: 2 articles (05/2012 - 09/2009)
8.	Vasil'eva, E D: 2 articles (03/2010 - 03/2004)
9.	Baginskaia, N V: 2 articles (03/2010 - 03/2004)
10.	Il'nitskaia, S I: 2 articles (03/2010 - 03/2004)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 04/15/1989 - "Studies of glucocorticoid and antiglucocorticoid induction of tyrosine aminotransferase (TAT) in two rat hepatoma cell lines (Fu5-5 and HTC) are described. " 01/01/1980 - "Studies on the different molecular forms of tyrosine aminotransferase from rat liver and hepatoma cells." 06/01/1971 - "A histochemical method for the demonstration of tyrosine aminotransferase in tissue culture cells, and studies of this enzyme in hepatoma tissue culture cells." 02/10/1971 - "Studies on the degradation of tyrosine aminotransferase in hepatoma cells in culture. " 05/01/2010 - "Down-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma."
2.	Starvation 02/01/1996 - "The activity of tyrosine aminotransferase significantly increased in the period between days 2 and 5 of starvation, after which a decrease to the level of satiated animals was observed in the terminal period. " 04/20/1983 - "The post-weaning increase in hepatic tyrosine aminotransferase of obese rats was only observed during the light phase of the diurnal cycle, but was prevented by pair-feeding and by starvation. " 01/03/1980 - "The tyrosine aminotransferase rhythm persisted even under starvation, though the amplitude decreased remarkably. " 01/01/2008 - "Here, we study a cycle of long-term starvation followed by refeeding in relation to the kinetics of serine dehydratase (SerDH) and tyrosine aminotransferase (TyrAT) in rainbow trout (Oncorhynchus mykiss). " 01/01/2008 - "Serine dehydratase and tyrosine aminotransferase activities increased by long-term starvation and recovery by refeeding in rainbow trout (Oncorhynchus mykiss)."
3.	Experimental Liver Neoplasms 01/01/1970 - "Further studies on the induction of tyrosine aminotransferase in Morris hepatoma 9618A." 03/01/1991 - "[Differences in expression and functional organization of the rat tyrosine aminotransferase gene in two lines of Morris hepatoma, 8994 and 7777]." 03/01/1991 - "Expression and structural organization of tyrosine aminotransferase (TAT) gene in Morris hepatoma cell line 7777 with active and glucocorticoid-inducible TAT gene and in hepatoma 8994, where TAT gene does not function were analysed. " 03/01/1988 - "[Regulation of the transcription of the tyrosine aminotransferase gene by glucocorticoids in Morris hepatoma 7777 and 8994 cells]." 04/01/1985 - "The transfer of Morris hepatoma cells induced by the hormone within 10-60 min in to a hormone-free medium is associated with the augmentation of tyrosine aminotransferase synthesis. "
4.	Photophobia (Light Sensitivity) 05/01/2011 - "In the present study we report the clinical features and the molecular genetic investigation of the tyrosine aminotransferase (TAT) gene in a young girl from Croatia with Richner-Hanhart syndrome, mainly suffering from photophobia, hyperkeratosis of the palmes and soles and slight neurological abnormalities. " 11/01/2011 - "A girl, born to unrelated Spanish parents, presented at 6 months of age with photophobia, keratitis, palmar hyperkeratosis and high plasma tyrosine levels, indicative of tyrosinaemia type II. Analysis of the tyrosine aminotransferase (TAT) gene revealed a paternally inherited frameshift mutation c.1213delCinsAG at codon 405 causing a premature stop codon, and a maternally inherited deletion of 193kb encompassing the complete TAT gene and three neighbouring genes. "
5.	Meningioma (Meningiomas) 10/01/1989 - "Of the 10 samples examined for tyrosine aminotransferase activity, measurable enzyme activity was found in 7 of the 8 meningiomas, but not in the single hemangioblastoma nor in the single craniopharyngioma. " 07/01/1995 - "In this study, eight meningioma cell cultures were transiently transfected with a construct that contains two palindromic progesterone/glucocorticoid response elements in front of the thymidine kinase promoter and the chloramphenicol acetyl sequence of the tyrosine aminotransferase gene. "

Related Drugs and Biologics

1.	L-Serine Dehydratase (Serine Dehydratase)
2.	Dexamethasone (Maxidex)
3.	Insulin (Novolin)
4.	Phosphoenolpyruvate
5.	RNA (Ribonucleic Acid)
6.	Hanhart syndrome
7.	dexamethasone 21-methanesulfonate
8.	Insulin-Like Growth Factor Binding Protein 1
9.	Progesterone
10.	Methylnitronitrosoguanidine (MNNG)

Related Therapies and Procedures

1.	Adrenalectomy
2.	Protein-Restricted Diet (Diet, Protein Restricted)
3.	Injections