Monophenol Monooxygenase (Tyrosinase)

An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and oxygen to yield L-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as CATECHOL OXIDASE. EC 1.14.18.1.

Also Known As:

Networked: 2180 relevant articles (47 outcomes, 222 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chung, Hae Young: 16 articles (04/2015 - 02/2005)
2.	Moon, Hyung Ryong: 14 articles (12/2015 - 04/2011)
3.	Schadendorf, Dirk: 13 articles (01/2013 - 03/2002)
4.	Wolchok, Jedd D: 12 articles (01/2013 - 04/2003)
5.	Keilholz, Ulrich: 12 articles (05/2010 - 03/2002)
6.	Houghton, Alan N: 11 articles (01/2013 - 05/2002)
7.	Chun, Pusoon: 10 articles (12/2015 - 07/2012)
8.	Moridani, Majid Y: 10 articles (10/2015 - 01/2003)
9.	Thiel, Eckhard: 10 articles (05/2010 - 03/2002)
10.	Yamashita, Toshiharu: 9 articles (05/2015 - 08/2002)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 05/01/2001 - "These data suggest that tyrosinase:8-17 may be clinically useful for the treatment of patients with melanoma." 01/01/2000 - "In routine analysis of SN biopsies in melanoma patients, tyrosinase RT-PCR can be used effectively to preselect nodes for further IHC of serial sections. " 08/01/2010 - "Determination of MITF in addition to tyrosinase improved the detection of circulating melanoma cells in melanoma patients." 04/01/2004 - "Determination of MITF marker in addition to tyrosinase improved the detection of circulating melanoma cells in patients with metastatic melanoma." 04/01/2004 - "Data reported in the literature about the clinical significance of tyrosinase expression in the peripheral blood of disease-free melanoma patients are still controversial. "
2.	Neoplasms (Cancer) 06/01/2010 - "Both CD4 and CD8 T cells mediate equally effective in vivo tumor treatment when engineered with a highly avid TCR targeting tyrosinase." 07/01/2006 - "A modified tyrosinase-related protein 2 epitope generates high-affinity tumor-specific T cells but does not mediate therapeutic efficacy in an intradermal tumor model." 10/01/2015 - "The tyrosinase inhibitor 1-phenyl-2-thiourea (PTU) is used very widely with larval zebrafish to generate essentially transparent organisms through inhibition of melanogenesis, which has enabled many elegant studies in areas ranging from neurological development to cancer research. " 05/15/2010 - "In an earlier study, we described a patient who developed an anti-tyrosinase T-cell response leading to long-term tumor control. " 01/01/2010 - "The studies identified a potent therapeutic VRP vaccine, encoding tyrosinase related protein 2 (TRP-2), which provided a durable anti-tumor effect. "
3.	Experimental Melanoma 10/01/2009 - "In this study, the compound was evaluated for in vitro cellular tyrosinase and melanogenesis inhibitory activities in mouse B16 melanoma cells and for in vivo skin-whitening activity in human volunteers. " 10/30/1990 - "Our studies suggest that the adhesion-mediated modulation of pigmentation in B16 melanoma correlates with differential macromolecular interactions with the 3' end of the tyrosinase gene." 08/07/2015 - "After 2 days of culture in the presence of Wnt-CM, proliferation of B16 melanoma cells was inhibited, whereas tyrosinase activity was increased. " 05/01/2015 - "Inhibition of PAK4 over several days markedly decreased the levels of CREB, MITF, and tyrosinase in both HRM-2 mice and B16 melanoma cells. " 10/01/2013 - "In addition, MHY-794 effectively inhibited SNP (NO donor)-induced melanogenesis by directly inhibiting tyrosinase and diminishing NO-mediated melanogenesis signaling in B16 melanoma cells. "
4.	Hyperpigmentation 12/15/2015 - "Results from the present study suggest that CPA2 bearing a linear β-phenyl-α,β-unsaturated carbonyl scaffold may be the potential candidate for treatment of diseases associated with hyperpigmentation and that a linear β-phenyl-α,β-unsaturated carbonyl scaffold might be closely related to potent tyrosinase inhibition. " 06/01/2011 - "This study will enhance understanding of the mechanism of tyrosinase inhibition and will contribute to the development of effective drugs for use hyperpigmentation." 01/01/2011 - "Tyrosinase inhibition studies are needed due to the medicinal applications such as hyperpigmentation. " 07/01/2015 - "Hyperpigmentation mechanism of methyl 3,5-di-caffeoylquinate through activation of p38 and MITF induction of tyrosinase." 02/01/2015 - "Skin hyperpigmentation and browning of foods are undesirable phenomena which tyrosinase represents. "
5.	Vitiligo 09/01/2015 - "This is the first study to demonstrate the role of oxidized tyrosinase in vitiligo. " 07/01/1996 - "In the present study we point towards a newly defined autoantigen in vitiligo, the enzyme tyrosinase, which participates in the process of melanogenesis. " 09/01/2015 - "Our novel results support an association between oxidized tyrosinase and vitiligo autoimmunity. " 09/01/2015 - "Furthermore, vitiligo patients had lower levels of tyrosinase activity compared with healthy controls. " 09/01/2015 - "Experimentally induced anti-ROS-tyrosinase-IgGs show reactivity with tyrosinase from vitiligo patients. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Antigens
3.	MART-1 Antigen
4.	Melanins (Melanin)
5.	DNA (Deoxyribonucleic Acid)
6.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
7.	Peptides
8.	Biological Markers (Surrogate Marker)
9.	RNA (Ribonucleic Acid)
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Immunotherapy
2.	Lymph Node Excision (Lymph Node Dissection)
3.	Drug Therapy (Chemotherapy)
4.	Transplantation (Transplant Recipients)
5.	Lasers (Laser)