Tyrocidine

An antibiotic mixture produced by Bacillus brevis which may be separated into three components, tyrocidines A, B, and C. It is the major constituent (40-60 per cent) of tyrothricin, gramicidin accounting for the remaining 10-20 per cent active material. It is a topical antimicrobial agent, that is very toxic parenterally.

Also Known As:

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Rautenbach, Marina: 3 articles (07/2014 - 06/2007)
2.	Vosloo, Johan Arnold: 2 articles (07/2014 - 10/2013)
3.	Bansal, Poonam: 1 article (01/2021)
4.	Dhanda, Suman: 1 article (01/2021)
5.	Kumar, Raman: 1 article (01/2021)
6.	Singh, Jasbir: 1 article (01/2021)
7.	Cammue, Bruno P A: 1 article (07/2014)
8.	Dathe, Margitta: 1 article (07/2014)
9.	Delattin, Nicolas: 1 article (07/2014)
10.	Thevissen, Karin: 1 article (07/2014)

Related Diseases

1.	Malaria 10/01/2013 - "Previous work by our group illustrated that the more polar tyrocidines rich in Trp residues in their structure were more active toward Gram-positive bacteria, while the more non-polar tyrocidines rich in Phe residues had greater activity toward Plasmodium falciparum, one of the major causative pathogens of malaria in humans. " 06/01/2007 - "We have isolated the major components of tyrothricin, cyclic decapeptides collectively known as the tyrocidines, and tested them against the human malaria parasite Plasmodium falciparum using standard in vitro assays. " 06/01/2007 - "Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis."
2.	Infections 08/23/2022 - "Importantly, tyrocidine-derived peptide depicted minimal cytotoxicity to human cells and, thus, may be a potential candidate in the rational development of a treatment regimen against free-living amoebae infections. " 07/01/2014 - "Using a Caenorhabditis elegans infection model, we found that tyrocidine A potentiated the activity of caspofungin. "
3.	Starvation 12/15/1982 - "Under conditions of severe nitrogen starvation, brought about by nutritional shift-down, Bacillus brevis ATCC 8185 was unable to sporulate unless supplemented with the peptide antibiotic tyrocidine. "
4.	Hemolysis 03/20/1947 - "tyrocidine) obtained by plotting degree of hemolysis against time, were S-shaped. "
5.	COVID-19 01/01/2021 - "Binding affinity of Tyrocidine A and Gramicidin S with SARS-CoV-2 papain-like protease was - 13.1 kcal/mol and - 11.4 kcal/mol, respectively which might be inhibited COVID-19 by acting on the protease. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Anti-Bacterial Agents (Antibiotics)
3.	Tyrothricin
4.	Cyclic Peptides
5.	Peptide Hydrolases (Proteases)
6.	Nitrogen
7.	Gramicidin (Gramicidin A)
8.	Caspofungin (Cancidas)
9.	SARS-CoV-2 papain-like protease