Tunicamycin

An N-acetylglycosamine containing antiviral antibiotic obtained from Streptomyces lysosuperificus. It is also active against some bacteria and fungi, because it inhibits the glucosylation of proteins. Tunicamycin is used as tool in the study of microbial biosynthetic mechanisms.

Networked: 459 relevant articles (14 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shimazawa, Masamitsu: 10 articles (01/2015 - 10/2006)
2.	Hara, Hideaki: 10 articles (01/2015 - 10/2006)
3.	Jiang, Chen Chen: 7 articles (01/2015 - 06/2007)
4.	Zhang, Xu Dong: 7 articles (01/2015 - 06/2007)
5.	Hersey, Peter: 6 articles (02/2014 - 06/2007)
6.	Jin, Lei: 5 articles (01/2015 - 07/2011)
7.	Tsuruma, Kazuhiro: 4 articles (01/2013 - 01/2011)
8.	Kwon, Taeg Kyu: 3 articles (04/2015 - 10/2010)
9.	Tseng, Hsin-Yi: 3 articles (01/2015 - 02/2014)
10.	Wei, Wei: 3 articles (09/2013 - 07/2007)

Related Diseases

1.	Neuroblastoma 07/01/2006 - "Several chemically synthesized compounds were examined for protective effects against the cell damage in tunicamycin-treated human neuroblastoma IMR-32 cells. " 02/25/2004 - "In this study, we used a randomized ribozyme library and ER stress-mediated apoptosis (tunicamycin-induced apoptosis) in SK-N-SH human neuroblastoma cells as a selective phenotype to identify factors involved in this process. " 02/15/2014 - "Inhibition of PKR protects against tunicamycin-induced apoptosis in neuroblastoma cells." 01/01/2014 - "Neuroblastoma N2A cells were infected with adenovirus expressing myc-tagged DHCR24 (Ad-DHCR24) or lacZ (Ad-lacZ, serving as a control) and subjected to ER-stress, induced with Tunicamycin (TM). " 07/09/2013 - "Interestingly, PADI4 was up-regulated by various stresses such as H2O2, acrylamide, and tunicamycin in neuroblastoma SK-N-SH cells but inhibited by RG. "
2.	Melanoma (Melanoma, Malignant) 11/15/1984 - "In cultured melanotic melanoma, a marked decrease of pigmentation has been found to be induced by the addition of tunicamycin [Y. " 12/15/1988 - "Studies on tunicamycin treatment indicated that the core size of the molecule appeared to have a molecular weight of 69,000 and also suggested that the carbohydrate moiety was greatly responsible for the conformation of the mouse melanoma epitope. " 09/01/2015 - "Here we investigated gene expression profiles under ER stress in melanoma cells and found that IDH1 was dramatically increased with ER stress induced by tunicamycin. " 01/01/2013 - "Here we report that activation of the UPR response by tunicamycin (TM), an ER stress inducer, leads to accumulation of p27 and G1 cell cycle arrest in melanoma cells. " 07/01/2011 - "To establish a model of ER stress-induced apoptosis with tunicamycin and to examine whether Bim is dysregulated and its potential role in resistance of melanoma cells to apoptosis under endoplasmic reticulum (ER) stress. "
3.	Anoxia (Hypoxia) 01/01/2015 - "The mechanism involved was assessed by an in vivo mouse RIRI model and an in vitro hypoxia/reoxygenation model, and tunicamycin-stimulated NRK-52E cells were used to explore the GLPP-mediated alleviation of ER stress. " 02/17/2009 - "SERCA2a overexpression attenuates ERS induced by hypoxia or tunicamycin, and protects cardiomyocytes against ERS-mediated cellular injury." 02/17/2009 - "SERCA2a overexpression was found to relieve the expression of GRP78 induced by hypoxia and tunicamycin (49.1% and 50.4% decrease respectively), and to inhibit the activation of CHOP (52.7% and 66.1% decrease respectively). " 02/17/2009 - "Ventricular cardiomyocytes were obtained from a neonatal rat, cultured, and then randomly divided into 6 groups: normal control group; hypoxia group cultured in an airtight chamber gassed with 95% N(2)/5% CO2 at 37 degrees C for 72 hours so as to induce ERS; tunicamycin group treated with 10 microg/ml tunicamycin so as to induce ERS too; SERCA2a group transfected with recombinant adenovirus expressing the target gene SERCA2a (rAd-SERCA2a); SERCA2a + hypoxia group; and SERCA2a + tunicamycin group. " 09/01/2000 - "Among them, the transcript that begins with exon 1B was preferentially induced by hypoxia or tunicamycin treatment. "
4.	Neoplasms (Cancer) 09/01/2014 - "The aim of the present study was to investigate whether tunicamycin (TM) induces autophagy, as well as whether the inhibition of autophagy enhances the apoptosis ofbreast cancer cells induced by TM. " 08/01/2015 - "Tunicamycin (TN), one of the endoplasmic reticulum stress inducers, has been reported to inhibit tumor cell growth and exhibit anticarcinogenic activity. " 01/01/2014 - "Cancer cells were treated with tunicamycin (TM) for 8 and 24 h. " 01/01/2010 - "Here we show that tunicamycin, an antibiotic promoting ER stress, suppresses the expression of p21, a tumor suppressor that induces cell cycle arrest and inhibits apoptosis. " 05/31/2009 - "Thus, combined treatment with tunicamycin and TRAIL may offer an attractive strategy for safely treating resistant thyroid cancers."
5.	Ischemia 09/11/2008 - "Pretreatment with tunicamycin or thapsigargin significantly ameliorated renal dysfunction and injury after ischemia-reperfusion. " 05/07/2008 - "We evaluated the effect of a selective inducer of immunoglobulin heavy chain binding protein (BiP) (BiP inducer X; BIX) against both tunicamycin-induced cell death (in SH-SY5Y cells) and the effects of global transient forebrain ischemia (in gerbils). " 03/01/2014 - "In the present study, we examined the protective effects of PP1-12 (an inhibitor of the serine/threonine protein phosphatase PP1) against tunicamycin (TM)-induced apoptosis in cultured cardiomyocytes in vitro, as well as in an in vivo model of ischemia/reperfusion (I/R) injury in rat hearts. " 04/01/2009 - "In the present study we propose that the cytoprotective effects attributed to 17beta-estradiol and tunicamycin in an in vivo rodent model of ischemia are reflected by changes in neuronal tissue levels of m-calpain, HSP70, GRP94 and GRP78. " 05/01/2012 - "We investigated the possible role of ER stress in retinal vascular degeneration in vivo, and the effects of resveratrol on tunicamycin and ischemia and reperfusion (I/R)-induced retinal vascular degeneration. "

Related Drugs and Biologics

1.	Thapsigargin
2.	Glucosamine (Dona)
3.	Caspase 3 (Caspase-3)
4.	Threonine (L-Threonine)
5.	salubrinal
6.	Serine (L-Serine)
7.	Carbenoxolone
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Dithiothreitol (Cleland's Reagent)
10.	Staurosporine

Related Therapies and Procedures

1.	Immunotherapy
2.	Aftercare (After-Treatment)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Intraperitoneal Injections
5.	Intravenous Injections