Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

Also Known As:

Networked: 62515 relevant articles (2724 outcomes, 7315 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Jing: 66 articles (01/2022 - 08/2004)
2.	Zhang, Wei: 60 articles (03/2022 - 11/2002)
3.	Sandborn, William J: 59 articles (01/2022 - 05/2002)
4.	Li, Wei: 58 articles (01/2022 - 07/2003)
5.	Wang, Yan: 57 articles (10/2022 - 04/2003)
6.	Li, Yan: 55 articles (12/2022 - 05/2003)
7.	Wang, Wei: 53 articles (01/2022 - 01/2003)
8.	Li, Jing: 52 articles (11/2022 - 08/2004)
9.	Cuzzocrea, Salvatore: 52 articles (01/2018 - 02/2003)
10.	Zhang, Jing: 49 articles (10/2022 - 08/2003)

Related Diseases

1.	Inflammation (Inflammations) 09/01/2018 - "Therapeutic strategies such as TNF-alpha blockers have dramatically improved the visual prognosis of patients with intraocular inflammation related to this chronic and potentially blinding condition." 12/01/2007 - "These developments include the use of magnetic resonance imaging (MRI) to visualize the inflammatory changes in the sacroiliac joint and the axial spine, and the demonstration that tumor necrosis factor (TNF) blocking agents are highly efficacious in reducing spinal inflammation and possibly in slowing radiographic progression. " 02/01/2007 - "These developments include the use of magnetic resonance imaging to visualize the inflammatory changes in the sacroiliac joint and the axial spine, and the demonstration that tumor necrosis factor blocking agents are highly efficacious in reducing spinal inflammation and possibly in slowing radiographic progression. " 08/08/2022 - "Immunohistochemistry of tumor necrosis factor alpha (TNF-α) revealed a marked decrease in inflammation. " 07/01/2010 - "Considering the important role of transmembrane TNF-alpha in granulomatous inflammation, reviewing the biology of transmembrane TNF-alpha and its interaction with anti-TNF agents will contribute to understanding the bases of differential clinical efficacy of these promising treatment modalities."
2.	Rheumatoid Arthritis 06/01/2014 - "In recent years Tumor Necrosis Factor alpha (TNF alfa) inhibitors have been highly effective in treating rheumatoid arthritis (RA). " 07/27/2012 - "The treatment of rheumatoid arthritis (RA) patients with anti-tumor necrosis factor alpha (TNFα) biological drugs has dramatically improved the prognosis of these patients. " 12/01/2014 - "Anti-TNF-alpha drugs are groundbreaking drugs, the efficacy of which has been proven in the treatment of rheumatoid arthritis. " 06/01/2012 - "Finding an effective treatment strategy for rheumatoid arthritis (RA) patients who have not benefited from previous tumor necrosis factor-α antagonist treatment is important for minimizing RA disease activity and improving patient outcomes. " 11/23/2002 - "In all, 14 patients with severe rheumatoid arthritis and treated by one of the two TNFalpha drugs (and in whom treatment was stopped because of adverse events or inefficacy) benefited from the switch to the other anti- TNFalpha, with excellent response in 8 out of 14 patients."
3.	Crohn Disease (Crohn's Disease) 08/01/2013 - "Both thiopurines and anti-tumor necrosis factor (TNF) α agents are effective for treating Crohn's disease (CD) as they can induce clinical remission (CR) and mucosal healing (MH) in most patients. " 06/01/2016 - "The purpose of this study was to describe the CT enterographic (CTE) findings after endoscopic complete remission (CR) of Crohn disease in patients treated with anti-tumor necrosis factor-α (anti-TNF-α) and the clinical implications of these findings. " 01/01/2022 - "Our study indicates the significant improvement in work productivity and activity impairment and quality of life of patients with Crohn's disease who receive long-term anti-tumor necrosis factor treatment." 01/01/2023 - "In Crohn's disease (CD), the aforementioned parameters were slightly higher than those for PBO, but there was not statistically significant in endoscopic remission and the efficacy of anti-tumor necrosis factor-naive patients. " 12/01/2017 - "Many reports indicate that a high-serum trough level of anti-tumor necrosis factor (TNF) agents is required for sustained remission in patients with Crohn's disease The pharmacokinetics of anti-TNF agents in inflamed intestinal tissue, however, is not well investigated. "
4.	Neoplasms (Cancer) 11/01/2004 - "The hybrids also induced the most potent CTLs, offered the highest protection against established EG7 tumors and also induced the highest stimulation of IFN-gamma and TNF-alpha production. " 08/01/2008 - "The augmentation in vivo was significantly greater than that in vitro, with complete cell death up to the iceball edge in tumor tissue at local TNF-alpha doses greater than 200 ng. " 09/25/2023 - "Sensitive detection of tumor necrosis factor-alpha (TNF-α) in human serum is beneficial for finding cancer patients early due to overexpressed TNF-α being related to some cancers. " 07/01/2007 - "In hind limb tumors, the same dose resulted in significant tumor shrinkage and remission in 2 of 8 (for soluble TNF-alpha) and in 3 of 8 (for CYT-6091). " 09/01/2000 - "In an adoptive transfer model, TNF-alpha-cultured TDLN cells mediated significantly greater regression of established tumor than did TDLN cells cultured in the absence of TNF-alpha in five of five experiments. "
5.	Necrosis 01/01/2009 - "Anti-tumour necrosis factor-alpha (anti-TNFalpha) agents can cause a dramatic improvement in disease activity and functional capacity, making complete remission of RA a possible target. " 04/01/2000 - "Tumour necrosis factor-alpha (TNFalpha) has been found to be very effective in the isolated limb perfusion setting for advanced extremity tumours. " 11/01/2007 - "Randomised controlled trials (RCTs) evaluating the efficacy of antagonists to tumour necrosis factor alpha (TNFalpha) showed high response percentages in the groups treated with active drugs. " 01/01/2006 - "Administration of high-dose LA on the other hand led to a significant reduction in necrosis- and apoptosis-related cell death in IRI of the liver without a reduction in liver TNFalpha." 01/01/2006 - "smegmatis expressing PE_PGRS 33 was associated with macrophage aggregation and clearance of macrophage monolayers, visible cell necrosis and significantly greater levels of TNF (TNF-alpha) in the cultures compared with controls. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Interleukin-6 (Interleukin 6)
3.	Cytokines
4.	Infliximab (Remicade)
5.	Interleukins
6.	Monoclonal Antibodies
7.	Proteins (Proteins, Gene)
8.	Etanercept (Enbrel)
9.	Interleukin-10 (Interleukin 10)
10.	Adalimumab (Humira)

Related Therapies and Procedures

1.	Therapeutics
2.	Biological Therapy
3.	Immunotherapy
4.	Drug Therapy (Chemotherapy)
5.	Aftercare (After-Treatment)