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Biological Tumor Markers (Tumor Markers)

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Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

Also Known As:

Tumor Markers; Tumor Markers, Biological; Biochemical Tumor Markers; Biological Tumor Marker; Marker, Biochemical Tumor; Marker, Biologic Tumor; Marker, Biological Tumor; Marker, Neoplasm Metabolite; Marker, Tumor Metabolite; Markers, Biochemical Tumor; Markers, Biological Tumor; Markers, Neoplasm Metabolite; Markers, Tumor Metabolite; Metabolite Markers, Tumor; Neoplasm Metabolite Markers; Tumor Markers, Biologic; Tumor Metabolite Marker; Biochemical Tumor Marker; Biologic Tumor Marker; Biologic Tumor Markers; Markers, Biologic Tumor; Markers, Carcinogen; Metabolite Marker, Neoplasm; Metabolite Marker, Tumor; Neoplasm Metabolite Marker; Tumor Marker, Biochemical; Tumor Marker, Biologic; Tumor Marker, Biological; Tumor Metabolite Markers; Carcinogen Markers; Markers, Tumor; Metabolite Markers, Neoplasm; Tumor Markers, Biochemical

Networked: 4681 relevant articles (176 outcomes, 529 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Biological Factors: 1315
- Biological Markers: 56388
  - Biological Tumor Markers: 4681

Experts

1.	Szmitkowski, Maciej: 32 articles (01/2015 - 01/2002)
2.	Mroczko, Barbara: 20 articles (02/2012 - 01/2002)
3.	Topolcan, O: 13 articles (12/2011 - 03/2003)
4.	Molina, Rafael: 12 articles (10/2015 - 05/2003)
5.	Bast, Robert C: 11 articles (01/2016 - 05/2003)
6.	Hayes, Daniel F: 11 articles (08/2015 - 06/2006)
7.	Diamandis, Eleftherios P: 11 articles (06/2015 - 08/2002)
8.	Toyoda, Hidenori: 10 articles (04/2015 - 01/2006)
9.	Kumada, Takashi: 10 articles (04/2015 - 01/2006)
10.	Holubec, L: 10 articles (06/2014 - 03/2003)

Related Diseases

1.	Neoplasms (Cancer) 10/01/1998 - "All elevated tumor markers improved dramatically after the removal of the tumor. " 05/01/1989 - "The evaluation was made both for patients who were "potentially curable" by surgery and, among those, for patients who were "potentially cured." Using the Cox regression model, the serum levels of the three tumor markers, together with the knowledge of whether or not the tumor was polypoid were combined to make up the set of variables that best predicted patient outcome. " 04/01/2012 - "The result was marked tumor response by positron emission tomography and computed tomography as well as significant improvement of the patient's quality of life accompanied by a substantial decrease of his tumor markers." 11/01/2011 - "Diagnostic imaging and tumor markers showed a marked improvement after 4 courses of S-1/IFN therapy, and he is still alive with good condition without recurrence and progression of tumors." 09/01/2007 - "Inspite of these limitations, many tumor markers have shown excellent clinical relevance in monitoring efficacy of different modes of therapies during entire course of illness in cancer patients. "
2.	Neoplasm Metastasis (Metastasis) 04/01/1982 - "We conclude that tumor markers and lymphangiography measurements are equally effective in the diagnosis of retroperitoneal lymph node metastases and that diagnostic accuracy is enhanced significantly by combining these 2 modalities. " 01/01/2011 - "Following the dynamics of tumor markers and LFTs may help to find metastatic disease in UM patients before the metastases are detectable by imaging, enabling earlier treatment." 04/01/2008 - "The patient has since remained disease-free, with normal levels of serum tumor markers and no evidence of metastasis on chest X-ray and abdominal CT." 11/01/2013 - "There was few study concentrated on the correlation between the evaluated tumor markers and lymph node metastasis. " 09/01/2009 - "This study was to evaluate the prognostic value of metastasis-related tumor markers in CRC. "
3.	Carcinoma (Carcinomatosis) 01/01/2008 - "Ancillary methods, such as immunocytochemistry, flow cytometry, image analysis, fluorescence in situ hybridization (FISH) and the newly discovered method of global analysis of gene expression are helpful in resolving cases with inconclusive cytology and are vigorously investigated for their value in assessing the expression of novel tumor markers for the diagnosis and prognosis of pancreatic and bile duct carcinomas. " 12/01/2001 - "Once the limitations leading to false positive results are controlled by urinalysis and by starting sample collection when basal levels are reached in patients with intravesic therapy, urinary tumor markers might eventually individualize the intervals between cystoscopies in the surveillance of patients with bladder carcinoma." 10/01/2001 - "We suggest that chest CT scanning could be eliminated in the routine follow-up of patients who have been treated for ovarian carcinoma; yet it should be performed for those patients with elevated serum tumor markers but without evidence of abdominal or pelvic disease." 11/01/2013 - "The present study represents the first attempt at prognostic stratification of multiple tumor markers in one cohort of patients with ovarian serous carcinoma effusions. " 10/01/2013 - "This study aims to identify serum tumor markers as preoperative prognostic factors and other variables as postoperative prognostic factors for ampulla of Vater carcinoma. "
4.	Ovarian Neoplasms (Ovarian Cancer) 12/01/1990 - "Finally, if tumor markers are to become more effective for ovarian cancer screening, it will be necessary to find ones that are more sensitive to ovarian cancer." 05/01/2009 - "Our data should contribute to an improved understanding of tumorigenesis in ovarian cancer, and aid in the development of diagnostic tumor markers and molecular-targeting therapy for patients with the disease." 05/01/1995 - "Elevations in single tumor markers, combinations of markers, and exponential increases of markers have all produced false-positive results for ovarian cancer within the 12-month follow-up period. " 09/01/1990 - "Thus, prediction of recurrence of ovarian cancer can be improved by the use of a combination of these tumor markers." 02/01/2015 - "In this study we aimed to determine the risk factors leading to ovarian cancer in Turkish women population and show the tumor markers in this population. "
5.	Lung Neoplasms (Lung Cancer) 05/01/2007 - "FDG-PET in addition to chest CT and tumor markers for the diagnosis of the postoperative recurrence of lung cancer is considered to be beneficial in terms of avoiding excessive radiation exposure and limiting medical costs, but further evaluation in more patients is necessary." 01/01/2013 - "As expected, combinations of these tumor markers improved their sensitivity for lung cancer and different combination panels had their own usefulness. " 04/20/2008 - "Detection of the six tumor markers is helpful for diagnosis lung cancer. " 11/01/2014 - "This article reviews the progress in the study of serum tumor markers of lung cancer. " 11/01/2014 - "Advances in the study of serum tumor markers of lung cancer."

Related Drugs and Biologics

1.	alpha-Fetoproteins (AFP)
2.	Biological Markers (Surrogate Marker)
3.	Carcinoembryonic Antigen
4.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)
5.	Antigens
6.	irinotecan (Camptosar)
7.	antigen CYFRA21.1
8.	Macrophage Colony-Stimulating Factor
9.	Nucleosides
10.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Radiotherapy
4.	Laparotomy
5.	Orchiectomy (Orchidectomy)