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Osteoarticular Tuberculosis

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Tuberculosis of the bones or joints.

Also Known As:

Tuberculosis, Osteoarticular; Bone Tuberculoses; Joint Tuberculoses; Osteoarticular Tuberculoses; Tuberculoses, Bone; Tuberculoses, Joint; Tuberculoses, Osteoarticular; Tuberculosis, Bone; Tuberculosis, Joint; Bone Tuberculosis; Joint Tuberculosis

Networked: 345 relevant articles (4 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Tuberculosis (Tuberculoses)
3.	Pulmonary Tuberculosis
4.	Meningeal Tuberculosis (Tuberculous Meningitis)
5.	Lymphatic Diseases (Lymphadenopathy)

Experts

1.	Agarwal, Anil: 4 articles (12/2015 - 10/2009)
2.	Harinath, B C: 4 articles (04/2003 - 08/2000)
3.	Huang, Hairong: 2 articles (07/2015 - 07/2013)
4.	Qin, Shibing: 2 articles (07/2015 - 07/2013)
5.	Ye, Xiaojian: 2 articles (04/2015 - 03/2011)
6.	Zhu, Min: 2 articles (04/2015 - 03/2011)
7.	Suri, Tarun: 2 articles (09/2014 - 12/2011)
8.	Kumar, Sudhir: 2 articles (04/2014 - 10/2009)
9.	Enache, S D: 2 articles (01/2009 - 01/2005)
10.	Kumar, S: 2 articles (03/2003 - 06/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteoarticular Tuberculosis:

1.	Isoniazid (Ftivazide)FDA LinkGeneric 07/01/1955 - "[Results of isonicotinic acid hydrazide therapy of osteoarticular tuberculosis and of its complications in children]." 05/01/1955 - "[Osteoarticular tuberculosis and isonicotinic acid hydrazide]." 01/01/1955 - "[Results of isoniazid therapy of osteoarticular tuberculosis in children]." 12/08/1954 - "[Treatment of osteoarticular tuberculosis with isoniazid]." 07/01/1954 - "[Isonicotinic acid hydrazide in the treatment of osteoarticular tuberculosis]."
2.	IproniazidIBA 10/01/1956 - "[Iproniazid for bone and joint tuberculosis]." 07/01/1953 - "The use of iproniazid in the treatment of bone and joint tuberculosis." 01/01/1955 - "A comparison of the efficacy of iproniazid (marsilid) and isoniazid (rimifon) in the treatment of bone and joint tuberculosis."
3.	lipoarabinomannan (LAM)IBA 03/01/2013 - "The patients with a history of osteoarticular tuberculosis tend to show positive results of QFT-2-G test for a prolonged period, whereas significantly less positive results of TBGL/LAM tests in mid-long-term." 03/01/2013 - "To evaluate results of QFT-2G/TBGL/ LAM in patients who had been completed the antituberculosis treatment for osteoarticular tuberculosis with various periods after the completion of the treatment, Fifty-five patients who had been completed the antituberculosis treatment for osteoarticular tuberculosis at least one year after the completion of treatment were evaluated using QFT-2G/TBGL/LAM tests. " 03/01/2013 - "[Evaluation using QFT-2G/TBGL/LAM in the patients with osteoarticular tuberculosis of post-treatment period]." 02/01/1990 - "The serum antibody to lipoarabinomannan-B(LAM-B) purified from mycobacterium tuberculosis (H37Ra) was tested by ELISA in 250 sera, including sera from patients as follows: tuberculosis 96, tubercular pleurisy 11, renal tuberculosis 2, bone and joint tuberculosis 33, tubercular meningitis 16, pulmonary cancer 22, leprosy 20 and normal subjects 50. "
4.	Streptomycin (Streptomycin Sulfate)FDA Link 01/18/1954 - "[Evaluation of action of streptomycin in certain forms of osteoarticular tuberculosis in children according to microscopic and bacteriologic studies]." 01/01/1952 - "Studies on the concentration of streptomycin the treatment of bone and joint tuberculosis." 07/01/1994 - "The first use of streptomycin for bone tuberculosis: a 47-year follow-up." 11/01/1964 - "[INTRAOSEOUS INJECTION OF STREPTOMYCIN IN THE TREATMENT OF OSTEOARTICULAR TUBERCULOSIS]." 01/01/1961 - "[BCG and streptomycin therapy in rabbits of osteoarticular tuberculosis caused by Mycobacterium tuberculosis resistant and sensitivity to streptomycin]."
5.	Rifampin (Rifampicin)FDA LinkGeneric 01/01/2014 - "Several studies have shown that the intralesional concentration of rifampicin in osteoarticular tuberculosis is typically at a subtherapeutic level. " 08/01/1973 - "[Clinical studies on the effects of rifampicin for bone and joint tuberculosis (author's transl)]." 03/01/1973 - "[Clinical studies on the effects of rifampicin for severe bone and joint tuberculosis]." 01/01/2014 - "Rifampicin MIC test in rifampicin-resistant isolates from patients with osteoarticular tuberculosis." 03/01/1973 - "[The effects of rifampicin on bone-joint tuberculosis with fistulation]."
6.	AntigensIBA 03/01/2003 - "To isolate and characterise in vivo released 41 kDa mycobacterial antigen in pulmonary and bone and joint tuberculosis (TB) and its identification with in vitro released ES-41 kDa antigen. " 03/01/2003 - "Isolation and characterisation of in vivo released 41 kDa mycobacterial antigen in pulmonary and bone and joint tuberculosis and its identification with H37Ra in vitro released antigen." 11/01/2002 - "Humoral immune response against 38-kDa and 16-kDa mycobacterial antigens in bone and joint tuberculosis." 08/01/2000 - "Out of total 36 bone & joint tuberculosis cases, tubercular antibody was detected by indirect ELISA in 30 patients (sensitivity 83%), while circulating tubercular antigen was detected by sandwich ELISA in 27 patients (sensitivity 75%). " 08/01/2000 - "Detection of tubercular antibody and antigen in sera of bone and joint tuberculosis."
7.	AntibodiesIBA 10/01/1959 - "[Electrophoretic study on blood antibodies in osteoarticular tuberculosis]." 06/01/1992 - "We discuss the case of a 22-year-old female, carrying of antibodies to against human immunodeficiency virus (HIV), who developed several tumors on different bone localizations, which corresponded to plurifocal bone tuberculosis. " 04/01/2003 - "This study is of interest that different antigen protein fractions of M.tb exhibit differential seroreactivity, as ES-31 protein showed good potential in detecting tuberculous IgG antibodies in tuberculous lymphadenopathy (TBLN) & tuberculous meningitis (TBM), while ES-41 in abdominal and bone & joint tuberculosis cases." 12/01/2012 - "Compared to patients with osteoarticular tuberculosis without HBV/HCV/HIV infection, patients with chronic HBV/HCV/HIV virus infection had similar positive rate of laboratory tests including tissue smear acid-fast bacilli (AFB) staining, tissue Mycobacterium tuberculosis (Mtb) culture, tissue Mtb DNA detection, serological test of antibodies against Mtb, and Mtb. " 08/01/2000 - "Trichloroacetic acid (TCA) solubilized and DEAE fractionatedMycobacterium tuberculosis H(37)Ra excretory-secretory (ES) antigen viz., Mtb EST DE1 and affinity purified goat antibodies to the TCA solubilized ES antigen (Mtb EST) were explored in detecting tubercular antibody and antigen respectively in sera of bone and joint tuberculosis by indirect and sandwich ELISA. "
8.	Anti-Bacterial Agents (Antibiotics)IBA 04/01/1962 - "[Surgical therapy of osteoarticular tuberculosis in the era of antibiotics]." 08/15/1958 - "[Osteoarticular tuberculosis and antibiotics]." 06/30/1957 - "[Tuberculous bacilli in bone tuberculosis subjected to antibiotics; therapeutic considerations]." 04/01/1956 - "[Antibiosis in osteoarticular tuberculosis and the effect of antibiotics]." 01/01/1956 - "[Modifications initiated by the use of antibiotics and recent chemical products in the operative therapy of osteoarticular tuberculosis]."
9.	DNA (Deoxyribonucleic Acid)IBA 03/01/2015 - "Archaeological finds, including human and animal remains (especially the aurochs), are particularly studied by palaeopathologists, as mycobacteria frequently cause bone involvement and this characteristic is of particular interest for palaeopathological (even macroscopic) studies; the interest is to detect the ancient DNA of MT, which is the cause of bone tuberculosis in skeletal remains as well as in mummies. " 02/01/2011 - "Clinical value of polymerase chain reaction in the diagnosis of joint tuberculosis by detecting the DNA of Mycobacterium tuberculosis." 01/01/2005 - "The authors reviewed the histopathological diagnostic in 19 cases of osteoarticular tuberculosis lesions selected from 390 cases of surgical extrapulmonary granulomatous lesions, using for difficult cases, with atypical lesions, new diagnostic tools as immunohistochemistry and DNA amplification technique by the polymerase chain reaction." 03/01/2003 - "The molecular identification of Mycobacterium tuberculosis DNA in ancient human remains has been achieved mainly in mummies with macroscopic changes but not in the skeletons without bone tuberculosis. " 03/01/2000 - "The diagnosis of bone tuberculosis was confirmed in the remains from Marvele by amplifiying a 245-bp fragment of a repetitive insertion element-like sequence (IS 6110) of Mycobacterium tuberculosis DNA. "
10.	Thioacetazone (Thiacetazone)IBA 05/01/1955 - "[The blood concentration of conteben and neoteben after intraossal administration in osteoarticular tuberculosis]." 08/03/1951 - "[Therapeutic results in 200 bone-and-joint tuberculosis cases with tuberculostatics, especially with conteben]." 01/01/1951 - "[Results of tuberculostatic substances, particularly conteben, in the treatment of 200 cases of osteoarticular tuberculosis]." 01/01/1954 - "[Therapeutic results in osteoarticular tuberculosis; critical studies on the use of coli-vaccine, conteben, PAS, streptomycin and neoteben in 410 patients, with special reference to the limits of chemotherapy]."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 04/01/2011 - "Both exudative and dependent forms of suppurative presentations of osteoarticular tuberculosis responded well to standard antitubercular chemotherapy. " 04/01/2015 - "After surgical treatment of osteoarticular tuberculosis (TB), it is necessary to fill the surgical defect with an implant, which combines the merits of osseous regeneration and local multi-drug therapy so as to avoid drug resistance and side effects. " 11/01/2014 - "Osteoarticular tuberculosis was frequent throughout the world a decade ago but antituberculous chemotherapy and prophylactic measures have clearly contributed to the reduction of its frequency. " 09/01/2014 - "We retrospectively evaluated the pretreatment radiological presentation and the clinicoradiological outcome at the completion of 1 year chemotherapy in osteoarticular tuberculosis of hip in children to prognosticate correlation between them. " 05/01/2002 - "Chemotherapy for osteoarticular tuberculosis."
2.	Debridement 01/01/1957 - "End results of focal debridement in bone and joint tuberculosis and its indications." 12/01/2009 - "At postoperative year one, the mean FAOS for pain improved to 85 from 26, whereas the mean FAOS for quality of life improved to 60 from 5. Tibiotalocalcaneal arthrodesis using a supracondylar femoral nail, combined with debridement and multidrug therapy, enabled a reliable one-stage solution for advanced osteoarticular tuberculosis and early return to function." 01/01/2005 - "Studies that focus on inflammatory OA, joint tuberculosis, septic joints, psoriatic joints (e.g., psoriatic knee joint synovitis), synovitis, chondropathy of the knee and gonarthrosis (which includes varotic gonarthrosis)Studies that focus on rheumatoid arthritisStudies that focus on meniscal tears from an acute injury (e.g., sports injury)Studies that are based on lavage or debridement for microfracture of the kneeStudies in which other surgical procedures (e.g., high tibial osteotomy, synovectomy, have been conducted in addition to lavage/debridement)Studies based on malalignment of the knee (e.g., varus/valgus arthritic conditions).Studies that compare lavage to lavage plus drug therapyStudies on procedures that are not arthroscopic (i.e., visually guided) (e.g., nonarthroscopic lavage)Studies of OA in children. "
3.	Arthrodesis 09/01/1956 - "[Arthrodesis in the treatment of osteoarticular tuberculosis]." 04/18/1952 - "[Arthrodesis in osteoarticular tuberculosis]." 01/01/1950 - "[Technic in arthrodesis in osteoarticular tuberculosis]." 12/01/2009 - "At postoperative year one, the mean FAOS for pain improved to 85 from 26, whereas the mean FAOS for quality of life improved to 60 from 5. Tibiotalocalcaneal arthrodesis using a supracondylar femoral nail, combined with debridement and multidrug therapy, enabled a reliable one-stage solution for advanced osteoarticular tuberculosis and early return to function."
4.	Microspheres (Microsphere) 01/01/2014 - "Comparing microspheres with different internal phase of polyelectrolyte as local drug delivery system for bone tuberculosis therapy." 01/01/2015 - "The study was to develop and evaluate the rifapentine-loaded poly(lactic acid-co-glycolic acid) (PLGA) microspheres (RPMs) for the treatment of osteoarticular tuberculosis to avoid critical side effects caused by oral regimens of antibiotics or intravenous antibiotics. "
5.	Osteotomy 01/01/2005 - "Studies that focus on inflammatory OA, joint tuberculosis, septic joints, psoriatic joints (e.g., psoriatic knee joint synovitis), synovitis, chondropathy of the knee and gonarthrosis (which includes varotic gonarthrosis)Studies that focus on rheumatoid arthritisStudies that focus on meniscal tears from an acute injury (e.g., sports injury)Studies that are based on lavage or debridement for microfracture of the kneeStudies in which other surgical procedures (e.g., high tibial osteotomy, synovectomy, have been conducted in addition to lavage/debridement)Studies based on malalignment of the knee (e.g., varus/valgus arthritic conditions).Studies that compare lavage to lavage plus drug therapyStudies on procedures that are not arthroscopic (i.e., visually guided) (e.g., nonarthroscopic lavage)Studies of OA in children. "