Tubercidin

An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.

Also Known As:

Networked: 32 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Donohue, Terrence M: 1 article (01/2010)
2.	Kharbanda, Kusum K: 1 article (01/2010)
3.	Tuma, Dean J: 1 article (01/2010)
4.	Osna, Natalia A: 1 article (01/2010)
5.	Beard, Michael R: 1 article (01/2010)
6.	White, Ronda L: 1 article (01/2010)
7.	Shu, Shi: 1 article (12/2006)
8.	Korn, Edward D: 1 article (12/2006)
9.	Liu, Xiong: 1 article (12/2006)
10.	Liu, Wenli: 1 article (12/2006)

Related Diseases

1.	Lymphoid Leukemia 07/01/1981 - "In in vivo studies against L1210 lymphoid leukemia in mice, the 1-beta-D-arabinofuranosylcytosine 5'-diphosphate-5'-L-1,2-dipalmitin showed an increased efficacy (increased life span, 260%) relative to the parent ara-C (increased life span, 89%) regardless of treatment schedule used, whereas the tubercidin 5'-diphosphate-5'-L-1,2-dipalmitin appeared extremely toxic even at low dosages. " 07/01/1981 - "The nucleoside 5'-diphosphate-L-1,2-dipalmitin derivatives of 1-beta-D-arabinofuranosylcytosine (ara-C), 9-beta-D-arabinofuranosyladenine (ara-A), and tubercidin have been synthesized, and their cytotoxicity has been evaluated against a mouse myeloma cell line (MPC-11) in vitro and against L1210 lymphoid leukemia both in vitro and in vivo. "
2.	Schistosomiasis (Bilharziasis) 03/01/1991 - "Efficacy of combination therapy with tubercidin and nitrobenzylthioinosine 5'-monophosphate against chronic and advanced stages of schistosomiasis." 06/01/1989 - "Host toxicity of the dose regimen of tubercidin (7-deazaadenosine) plus nitrobenzylthioinosine 5'-monophosphate (NBMPR-P) used in combination therapy of schistosomiasis (M. " 06/01/1989 - "Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis." 11/01/1983 - "Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate." 03/01/1991 - "The efficacy of the highly selective antischistosomal combination chemotherapy with tubercidin (7-deazaadenosine) plus nitrobenzylthioinosine 5'-monophosphate (NBMPR-P), [el Kouni et al., Proc Natl Acad Sci USA 80: 6667-6670, 1983; el Kouni et al., Biochem Pharmacol 36: 3815-3821, 1987] was examined against chronic and advanced stages of schistosomiasis in mice. "
3.	Infection 03/01/1991 - "Administration of four successive daily doses of tubercidin (5 mg/kg/day) plus NBMPR-P (25 mg/kg/day) to Schistosoma mansoni-infected mice beginning 5, 6, 7 and 8 weeks post-infection and monitored for 22 weeks was very effective against the parasite. " 04/01/1989 - "The infection of human erythrocytes by two strains of the human malarial parasite, Plasmodium falciparum (FCQ-27 or the multi-drug-resistant strain K-1), markedly changed the transport characteristics of the nucleosides, adenosine and tubercidin, compared to uninfected erythrocytes. "
4.	Schistosomiasis japonica 01/01/1974 - "Comparative efficacy of one and two treatments with tubercidin against Schistosomiasis japonica in monkeys."
5.	Vesicular Stomatitis 11/15/1990 - "In a previous study [Cools M and De Clercq E, Biochem Pharmacol 38: 1061-1067, 1989], we found a close correlation between the antiviral activity of six adenosine analogues [S)-9-(2,3-dihydroxypropyl)adenine [(S)-DHPA], (RS)-3-adenin-9-yl-2-hydroxypropanoic acid [(RS)-AHPA] (isobutyl ester), 3-deazaneplanocin A, carbocyclic 3-deazaadenosine (C-c3 Ado), adenosine dialdehyde and neplanocin A) against vaccinia virus and vesicular stomatitis virus and the inhibitory effect of these compounds on purified AdoHcy hydrolase isolated from murine L929 cells. "

Related Drugs and Biologics

1.	Cytarabine (Cytosar-U)
2.	nitrobenzylthioinosine 5'-monophosphate
3.	Adenosine
4.	Arachidonic Acid (Vitamin F)
5.	Adenine
6.	beta-apocarotenoid-14',13'-dioxygenase (ADO)
7.	3-adenin-9-yl-2-hydroxypropanoic acid isobutyl ester
8.	neplanocin A
9.	periodate-oxidized adenosine
10.	9-(2,3-dihydroxypropyl)adenine

Related Therapies and Procedures

1.	Combination Drug Therapy (Combination Chemotherapy)
2.	Intravenous Injections
3.	Intraperitoneal Injections
4.	Intravenous Infusions