Tryptamines (Triptans)

08/01/2013 - "Triptans represent the best treatment option for most migraine attacks, although this is not as well studied as it might be in controlled trials. "
10/01/2007 - "The efficacy of triptans for acute migraine has been well established in clinical trials but not in primary care, where they are most commonly prescribed. "
05/01/2015 - "Triptans represent the most specific and effective treatment for migraine attacks. "
02/01/2014 - "Triptans are the first-line treatment in acute attacks and the most effective drugs in various types of migraine. "
09/01/2007 - "Triptans seem to be safe and effective treatment for most hemiplegic migraine patients."

02/01/2002 - "Important pharmacologic, pharmacokinetic, and clinical differences exist among those drugs, but the tolerability profile of the newer triptans is very good, and they provide rapid relief from headache and sustained duration of effect. "
09/01/2006 - "The group treated with TPM had a significant reduction in the number of days with headache (P < 0.0001 vs placebo) and in the mean amount of acute medication taken (P < 0.0001 vs placebo); all triptans were superior to placebo; there were no significant differences between different triptans; the analgesic effect of triptans increased throughout the trial. "
05/01/2012 - "Why triptans are effective in so different types of primary headaches remain unclear. "
02/01/2011 - "For evaluating the efficacy of acute medication we compared triptans with other compounds using headache duration as outcome parameter. "
09/01/2006 - "We also studied the efficacy of single triptans available in Italy in interrupting headache crises during preventive treatment. "

07/01/2004 - "Triptans, 5HT1 receptor agonists, can be highly effective in treating pain and reducing disability. "
06/01/2014 - "A growing list of studies show efficacy of multiple triptans and other 5HT1b/1d agonists in preclinical models of nonheadache pain arguing for reevaluation of whether these drugs have efficacy in other pain states. "
02/01/2007 - "Although clinical trials have reported improved outcomes when triptans were used early or to treat mild pain, acceptance of this treatment strategy has been hampered by both efficacy and tolerability issues. "
04/05/2015 - "Combinationalformulationof triptans and a nonsteroidal anti-inflammatory drug may provide a quicker and longer duration of relief from the subsequent pain during the attack. "
06/01/2014 - "And with the list of studies demonstrating efficacy triptans in models of nonheadache, clinical studies should address whether these drugs work for other types of pain."

01/01/2014 - "Triptans are only effective in terminating cluster headache (CH) attacks in 70-80% of patients. "
12/01/2013 - "Triptans are effective for immediate relief of episodic cluster headache (CH) but do not reduce the frequency of attacks. "
01/01/2013 - "Randomised, double-blind, placebo-controlled studies of triptans for acute treatment of cluster headache episodes. "
01/01/2010 - "Randomised, double-blind, placebo-controlled studies of triptans for acute treatment of cluster headache episodes. "
01/01/2013 - "Triptans for acute cluster headache."

03/01/2013 - "These results support the suggestion that triptans and β-blockers interact with the endothelial cell component of the blood vessel to produce anti-hyperalgesia."
03/01/2010 - "Sustained or repeated administration of triptans to rats elicited time-dependent and reversible cutaneous tactile allodynia that was maintained throughout and transiently after drug delivery. "
12/01/2008 - "It has been hypothesized that treatment success with triptans may be severely impaired in the presence of allodynia. "
09/19/2007 - "To avoid a cutaneous allodynia it is necessary to introduce as soon as possible the treatment with triptans. "
09/01/2007 - "The presence of cutaneous allodynia may predict response to triptans. "