A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premature activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS.
Also Known As:
Trypsin Inhibitor, Kazal Pancreatic; Inhibitor, Tumor-Associated Trypsin; Pancreatic Secretory Trypsin Inhibitor; SPINK1; Serine Peptidase Inhibitor, Kazal-Type 1; Serine Protease Inhibitor Kazal-Type 1; Trypsin Inhibitor Kazal Pancreatic; Trypsin Inhibitor, Tumor-Associated; Tumor-Associated Trypsin Inhibitor; Serine Peptidase Inhibitor, Kazal Type 1; Serine Protease Inhibitor Kazal Type 1; Trypsin Inhibitor, Tumor Associated; Tumor Associated Trypsin Inhibitor; Acidic Pancreatic Trypsin Inhibitor; Pancreatic Secretory Trypsin Inhibitor, Kazal; Pancreatic Trypsin Secretory Inhibitor, Kazal; Trypsin Inhibitor, Pancreatic Secretory