Trypanocidal Agents

01/01/1983 - "Mice infected with Trypanosoma brucei can be easily cured using the available trypanocidal drugs, provided treatment is given soon after the infection; however, if infection is allowed to continue for some time then it is extremely difficult to obtain a permanent cure, and after an aparasitaemic period the infection eventually relapses. "
06/12/2001 - "Finally, we describe tests in cattle that may be used to determine the efficacy of recommended curative doses of trypanocidal drugs for the treatment of infection with individual trypanosome isolates, including Trypanosoma vivax, which is rarely infective for mice."
11/01/1983 - "The amplitude, but not the onset of the increase in parasitaemia in sheep, was found to be related to the therapeutic efficacy of the trypanocides in the treatment of Trypanosoma congolense infection in rats. "
01/01/2012 - "Study investigated and compared, in an experimental Trypanosoma infection, the effects of two trypanocides on the pathology of tissues and some biochemical indices in rats. "
11/01/1995 - "These cattle were treated with trypanocidal drugs following each infection and had remained aparasitemic for 3 years prior to this study. "

01/01/2019 - "Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial."
10/15/1980 - "I. A study of trypanosomiasis occurrence and the use of trypanocidal agents]."
04/01/2022 - "At present, trypanosomiasis is treated with trypanocidal drugs, but access to these can be limited, and increasing parasite resistance raises questions about their efficacy. "
01/12/2022 - "Sub-Saharan Africa is profoundly challenged with African Animal Trypanosomiasis and the available trypanocides are faced with drawbacks, necessitating the search for novel agents. "
01/01/2021 - "Using effective trypanosomiasis such as integrated cattle injection with trypanocides and spraying can sufficiently slow the spread of rHAT in the network. "

12/11/2020 - "We included randomised controlled trials (RCTs) assessing trypanocidal drugs versus placebo or no treatment for late-stage, symptomatic Chagas disease and CCC. "
09/05/2023 - "Over 110 years after the first formal description of Chagas disease, the trypanocidal drugs thus far available have limited efficacy and several side effects. "
06/28/2021 - "Therefore, given its reduced toxicity, enhanced anti-trypomastigote activity, and curative properties, NFOH can be considered as a potential therapeutic option for Chagas disease, perhaps in combination with other trypanocidal agents."
12/11/2020 - "Trypanocidal drugs for late-stage, symptomatic Chagas disease (Trypanosoma cruzi infection)."
12/01/2020 - "Chagas disease, caused by the protozoan Trypanosoma cruzi, has increased in the world due to migration, travelling and climate change; at present, the principal problem is that common trypanocidal agents have resulted in toxic or inconvenient side effects. "

01/01/2022 - "Multi-drug cross-resistance against the only accessible trypanocides is a major public health risk, justifying the need to revise the policy in developing countries to promote control of African trypanosomiasis."
10/01/2010 - "Nagana is routinely controlled by the use of trypanocides and an overreliance on their use throughout past decades resulted in multiple drug resistance of trypanosomes in most parts of West Africa's cotton belt. "
06/01/1986 - "Control of African trypanosomiasis relies heavily on attempts to eliminate the tsetse fly vectors, and the use of trypanocidal drugs which are not entirely satisfactory. "
05/01/2019 - "Modelling appropriate use of trypanocides to restrict wide-spread multi-drug resistance during chemotherapy of animal African trypanosomiasis."
09/01/2009 - "The involvement of purine salvage in the accumulation of current trypanocidal drugs is important for the treatment of African sleeping sickness. "

08/01/2012 - "The best-bet strategy this study recommended for areas with multiple drug resistance included area-wide community tsetse control, control of co-infections to exploit self-cure against resistant trypanosome populations and the rational use of trypanocidal drugs which should be urgently promoted at all levels as a way of containing or reversing resistance."
07/01/2019 - "In addition beside tsetse control, rational use of trypanocidal drugs and control of co-infections to exploit self-cure against resistant trypanosome populations are recommended. "