Troponin

One of the minor protein components of skeletal muscle. Its function is to serve as the calcium-binding component in the troponin-tropomyosin B-actin-myosin complex by conferring calcium sensitivity to the cross-linked actin and myosin filaments.

Networked: 2265 relevant articles (65 outcomes, 250 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jaffe, Allan S: 47 articles (01/2016 - 11/2005)
2.	Mueller, Christian: 42 articles (01/2016 - 05/2008)
3.	Twerenbold, Raphael: 33 articles (09/2015 - 08/2009)
4.	Reichlin, Tobias: 31 articles (09/2015 - 08/2009)
5.	Lindahl, Bertil: 27 articles (11/2015 - 05/2002)
6.	Haaf, Philip: 25 articles (09/2015 - 06/2011)
7.	Cullen, Louise: 23 articles (12/2015 - 03/2011)
8.	Giannitsis, Evangelos: 23 articles (11/2015 - 12/2002)
9.	Reiter, Miriam: 23 articles (06/2015 - 06/2011)
10.	Apple, Fred S: 23 articles (04/2015 - 01/2002)

Related Diseases

1.	Myocardial Infarction 07/01/2012 - "Cardiac troponin represents a highly sensitive and specific marker of myocardial damage and is a current gold standard test for diagnosing acute myocardial infarction in the general population. " 02/21/2012 - "Rapid, highly sensitive troponin assays for the analysis of serum at the point-of-care are particularly desirable for the effective treatment of myocardial infarction (MYI). " 03/01/2009 - "The development of highly sensitive cardiac troponin (cTnI) assays has increased the number of true and false positive results for patients suspected of acute myocardial infarction (AMI). " 11/01/2014 - "The development of troponin assays with increased diagnostic sensitivity and greater analytic precision has improved the diagnosis of myocardial infarction in high risk patients. " 04/15/2013 - "Cardiac troponin, our current "gold standard" biomarker criterion for the diagnosis of myocardial infarction has high sensitivity and specificity for this diagnosis and therapies instituted in patients with elevated troponin have been shown to influence outcomes. "
2.	Acute Coronary Syndrome 01/01/2015 - "Despite the availability of high-sensitive troponin (hs-cTnT), there is still room for improvement in the diagnostic assessment of patients suspected of acute coronary syndrome (ACS). " 12/01/2013 - "Will high-sensitivity troponin assays lead to improved outcomes in patients with acute coronary syndrome?" 01/01/2011 - "High-sensitivity cardiac troponin assays have improved the detection of acute coronary syndrome. " 06/01/2012 - "Profs Hugo Katus and Christian Hamm discuss with Emma Wilkinson how their work on troponin has improved the diagnosis and treatment of acute coronary syndromes." 01/01/2016 - "Ultra-Sensitive Copeptin and Cardiac Troponin in Diagnosing Non-ST-Segment Elevation Acute Coronary Syndromes-The COPACS Study."
3.	Chest Pain (Chest Pains) 12/28/2011 - "Introduction of highly sensitive troponin assays into clinical practice has substantially improved the evaluation of patients with chest pain. " 12/01/2015 - "Addition of copeptin to troponin does not have significant improvement of the diagnostic accuracy of ACS in patients presented with chest pain." 01/01/2015 - "High-sensitivity troponin has significantly greater early sensitivity and NPV for the diagnosis of AMI at the cost of specificity and positive predictive value, which may enable early rule in/out of AMI in patients with chest pain. " 03/01/2006 - "Stress echocardiography is superior to exercise ECG in the risk stratification of patients presenting with acute chest pain with negative Troponin." 10/01/2011 - "Two recent clinical trials showed that adding copeptin to a conventional cardiac troponin assay improved diagnostic performance for patients with chest pain early after symptom onset. "
4.	Necrosis 07/01/2014 - "The continuing advances in the biochemical research for the discovering an ideal biomarker for diagnosing myocardial injury have led to discovery cardiac Troponin, a biochemical gold standard for myocardial necrosis. " 10/15/2006 - "With respect to troponin, transmural necrosis improved the predictive power of LV remodeling (R2 for change = 0.19) and function (R2 for change = 0.16). " 01/15/2014 - "In this in vivo rat study (0.5mg/kg), serum troponin concentrations increased with lesion severity, minimal to mild necrosis at 24 and 48h. " 05/01/2005 - "The importance of this marker and the heterogeneousness of circulating forms of troponin after myocardial necrosis fully justify international studies about standardization of this assay, which is a central bulk to reach a global market coherence. " 10/01/2015 - "Cardiac necrosis as measured by troponin levels is significantly increased in people with ACS and stress hyperglycaemia. "
5.	Coronary Artery Disease (Coronary Atherosclerosis) 10/01/2015 - "Patients with recent-onset AF and troponin rise showed higher prevalence of coronary atherosclerosis and adverse cardiac events. " 10/01/2015 - "In the entire cohort, on multivariate analysis, the odds ratio for the occurrence of the primary end point of troponin rise was 14 (95% confidence interval [CI], 10-23; P<.001), and that of known coronary artery disease was 3 (CI, 2-5; P=.001). " 10/01/2015 - "We present a case and review of literature regarding patients who present with elevated troponin levels in the absence of any coronary artery disease. " 02/10/2015 - "Minimally elevated serum cardiac troponin reflects myocardial injury and is associated with increased mortality, even absent coronary artery disease (CAD). " 01/01/2015 - "[High-sensitivity troponin in patients with stable coronary artery disease]."

Related Drugs and Biologics

1.	MB Form Creatine Kinase
2.	Brain Natriuretic Peptide (Natrecor)
3.	Myoglobin
4.	pro-brain natriuretic peptide (1-76)
5.	trans-crotonin (CTN)
6.	Creatine Kinase (Creatine Phosphokinase)
7.	Biological Markers (Surrogate Marker)
8.	Troponin I
9.	C-Reactive Protein
10.	Trinitrotoluene (TNT)

Related Therapies and Procedures

1.	Angioplasty (Angioplasty, Transluminal)
2.	Drug Therapy (Chemotherapy)
3.	Stents
4.	Drug-Eluting Stents
5.	Length of Stay