Troponin

One of the minor protein components of skeletal and cardiac muscles. It functions as the calcium-binding component in a complex with BETA-TROPOMYOSIN; ACTIN; and MYOSIN and confers calcium sensitivity to the cross-linked actin and myosin filaments. Troponin itself is a complex of three regulatory proteins (TROPONIN C; TROPONIN I; and TROPONIN T).

Also Known As:

Networked: 6812 relevant articles (206 outcomes, 716 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mueller, Christian: 108 articles (12/2022 - 05/2008)
2.	Jaffe, Allan S: 89 articles (12/2022 - 05/2003)
3.	Twerenbold, Raphael: 73 articles (12/2022 - 08/2009)
4.	Mills, Nicholas L: 72 articles (07/2022 - 03/2011)
5.	Apple, Fred S: 66 articles (08/2022 - 01/2002)
6.	Lindahl, Bertil: 63 articles (02/2022 - 05/2002)
7.	Giannitsis, Evangelos: 59 articles (11/2022 - 12/2002)
8.	Cullen, Louise: 56 articles (11/2022 - 03/2011)
9.	Reichlin, Tobias: 55 articles (06/2021 - 08/2009)
10.	Kavsak, Peter A: 48 articles (01/2022 - 07/2006)

Related Diseases

1.	Myocardial Infarction 07/01/2012 - "Cardiac troponin represents a highly sensitive and specific marker of myocardial damage and is a current gold standard test for diagnosing acute myocardial infarction in the general population. " 02/21/2012 - "Rapid, highly sensitive troponin assays for the analysis of serum at the point-of-care are particularly desirable for the effective treatment of myocardial infarction (MYI). " 03/01/2009 - "The development of highly sensitive cardiac troponin (cTnI) assays has increased the number of true and false positive results for patients suspected of acute myocardial infarction (AMI). " 01/01/2022 - "As the methods of determining cardiac troponins improved, increasing their sensitivity (high-sensitivity cardiac troponins), the prospects for early diagnosis of acute myocardial infarction opened up, in particular, modern diagnostic algorithms: 0-1 hour, 0-2 hours, 0-3 hours. " 01/01/2022 - "Towards an improved definition of periprocedural myocardial infarction: The role of high-sensitivity cardiac troponins."
2.	Acute Coronary Syndrome 02/01/2019 - "Highly sensitive assays have diminished the positive predictive value of troponin in acute coronary syndromes and increased the importance of the clinical assessment in interpreting positive results. " 02/01/2000 - "The cardiac troponins are a highly sensitive and specific marker for myocardial damage and have been shown to be useful in the management of patients with acute coronary syndromes. " 01/01/2018 - "Troponin elevation identifies a high-risk population in both acute coronary syndrome and non-acute coronary syndrome populations, yet effective treatment for the latter is lacking." 12/01/2016 - "High-sensitivity cardiac troponin assays with improved analytical performance at low concentrations are credited with increased diagnostic sensitivity in acute coronary syndrome patients. " 01/01/2015 - "Despite the availability of high-sensitive troponin (hs-cTnT), there is still room for improvement in the diagnostic assessment of patients suspected of acute coronary syndrome (ACS). "
3.	Chest Pain (Chest Pains) 12/28/2011 - "Introduction of highly sensitive troponin assays into clinical practice has substantially improved the evaluation of patients with chest pain. " 10/18/2021 - "Coronary CT angiography for improved assessment of patients with acute chest pain and low-range positive high-sensitivity troponins: study protocol for a prospective, observational, multicentre study (COURSE trial)." 08/01/2021 - "We also report that a two-step HEART-based strategy may safely allow significant reduction of troponin measurements in patients presenting to the emergency department with chest pain." 12/01/2015 - "Addition of copeptin to troponin does not have significant improvement of the diagnostic accuracy of ACS in patients presented with chest pain." 01/01/2015 - "High-sensitivity troponin has significantly greater early sensitivity and NPV for the diagnosis of AMI at the cost of specificity and positive predictive value, which may enable early rule in/out of AMI in patients with chest pain. "
4.	Cardiovascular Diseases (Cardiovascular Disease) 06/07/2023 - "Troponin measurement could be helpful in the prediction of adverse cardiac events. " 01/01/2023 - "Time trajectories of troponin were constructed in those who died from cardiovascular disease compared to those who survived or died from other causes during follow up and these were externally validated in the HUNT Study. " 01/01/2023 - "The aim of this study is to identify a subgroup of patients with a low pre-test probability of major adverse cardiac events, for which there is no need of troponin testing, to avoid potential harm from false-positive testing and long length stay in ED. " 01/01/2020 - "A systematic search of PubMed, Embase and Science Citation Index Expanded was undertaken for observational studies published before March 2018 that reported associations between raised preoperative levels of high-sensitivity troponin and postoperative major adverse cardiac events and/or mortality after non-cardiac surgery. " 06/15/2019 - "In parallel with these changes, a number of studies indicate the persistence of the detectable troponins serum levels in CKD patients, even in the absence of clear clinical manifestations of cardiovascular diseases (CVD). "
5.	Necrosis 05/01/2016 - "Currently, cardiac troponins have the highest sensitivity and specificity for myocardial necrosis and represent the biochemical gold standard for diagnosing AMI. " 03/01/2009 - "Troponins are currently the "gold standard" test for the detection of myocardial necrosis, but they are unsuitable for early diagnosis, as nearly 50% of patients may present to the emergency department with non-diagnostic concentrations. " 10/15/2006 - "With respect to troponin, transmural necrosis improved the predictive power of LV remodeling (R2 for change = 0.19) and function (R2 for change = 0.16). " 01/15/2014 - "In this in vivo rat study (0.5mg/kg), serum troponin concentrations increased with lesion severity, minimal to mild necrosis at 24 and 48h. " 05/01/2005 - "The importance of this marker and the heterogeneousness of circulating forms of troponin after myocardial necrosis fully justify international studies about standardization of this assay, which is a central bulk to reach a global market coherence. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	trans-crotonin (CTN)
3.	Troponin
4.	Brain Natriuretic Peptide (Natrecor)
5.	MB Form Creatine Kinase
6.	C-Reactive Protein
7.	Myoglobin
8.	Natriuretic Peptides
9.	pro-brain natriuretic peptide (1-76)
10.	Clopidogrel (Plavix)

Related Therapies and Procedures

1.	Therapeutics
2.	Percutaneous Coronary Intervention
3.	Drug Therapy (Chemotherapy)
4.	Stents
5.	Length of Stay