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Tropomyosin

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A protein found in the thin filaments of muscle fibers. It inhibits contraction of the muscle unless its position is modified by TROPONIN.

Also Known As:

Miniparamyosin; Paratropomyosin; Tropomyosin Mg; alpha-Tropomyosin; beta-Tropomyosin; gamma-Tropomyosin; Mg, Tropomyosin; alpha Tropomyosin; beta Tropomyosin; gamma Tropomyosin; Paramyosin

Networked: 684 relevant articles (17 outcomes, 64 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wieczorek, David F: 16 articles (04/2014 - 09/2003)
2.	Solaro, R John: 11 articles (10/2015 - 10/2003)
3.	Redwood, Charles S: 11 articles (07/2015 - 12/2003)
4.	Robinson, Paul: 10 articles (08/2013 - 08/2005)
5.	Wolska, Beata M: 8 articles (10/2015 - 07/2007)
6.	Kuusisto, Johanna: 8 articles (09/2014 - 01/2003)
7.	Jääskeläinen, Pertti: 8 articles (09/2014 - 01/2003)
8.	Gunning, Peter W: 7 articles (12/2015 - 08/2004)
9.	Borovikov, Yurii S: 7 articles (07/2015 - 04/2009)
10.	Karpicheva, Olga E: 7 articles (07/2015 - 04/2009)

Related Diseases

1.	Infection 10/01/2010 - "The abundance of a pan-allergen like tropomyosin in parasitic worms and the counterintuitive, but well documented protection against allergic reactivity by some chronic helminth infections is discussed." 03/01/1998 - "Debates about how a non-surface protein such as paramyosin might provide protection against schistosome infections have recently been addressed by microscopy results. " 03/01/1993 - "Prior studies have shown that such immunization stimulates a much stronger antibody response to recombinant and native filarial paramyosin than that seen after normal infection. " 10/01/2009 - "Paramyosin is a muscular protein exclusively found in invertebrate species, which has been proposed as a vaccine candidate against infections with Schistosoma mansoni and Brugia malayi. " 06/01/2006 - "Localized accumulation of tropomyosin at the infection sites may facilitate parasite invasion."
2.	Hypersensitivity (Allergy) 02/01/2015 - "Therefore, the aim of this study was to isolate sulfated polysaccharide from Porphyra haitanensis (PHPS) and investigate its anti-allergic potential using a tropomyosin (TM)-induced mouse allergy model. " 11/01/2015 - "Patients with mollusc allergy reacted more frequently to tropomyosin in immunoblots than did patients without it (93% vs 35%, respectively, P = 0.004). " 10/01/2015 - "A recombinant hypoallergenic tropomyosin has been developed, which opens a new avenue in the treatment of shellfish allergy. " 01/01/2015 - "Gastrointestinal Immune Response to the Shrimp Allergen Tropomyosin: Histological and Immunological Analysis in an Animal Model of Shrimp Tropomyosin Hypersensitivity." 06/01/2014 - "The major allergen involved in allergy and cross-reactivity among different fish species was identified as parvalbumin while that responsible for shellfish (crustaceans and mollusks) allergy was identified as tropomyosin. "
3.	Schistosomiasis (Bilharziasis) 05/01/2010 - "To investigate intranasal (i.n.) immunization efficacy of Schistosoma japonicum 97-kDa myofibrillar protein paramyosin (PM), a vaccine candidate for Asian schistosomiasis, BALB/c mice were i.n. " 04/01/1995 - "The study shows that Lumbricus sp. represent a potential source for paramyosin and other candidate vaccine molecules for schistosomiasis." 01/01/2015 - "Development of Paramyosin as a Vaccine Candidate for Schistosomiasis." 01/01/2014 - "The bar to achieve protective efficacy in humans was set at a consistent induction of 40% protection or better by the World Health Organisation (WHO), and although this is a modest goal, it is yet to be reached with the six most promising schistosomiasis vaccine candidates (Sm28GST, IrV5, Sm14, paramyosin, TPI, and Sm23). " 07/01/2008 - "Our method for pilot-scale production of recombinant full-length paramyosin will facilitate preclinical evaluation of paramyosin as a vaccine for schistosomiasis."
4.	Pain (Aches) 01/09/2014 - "Inhibitors of Tropomyosin-Receptor Kinases (Trk's): Potential Pain Therapy and More." 07/31/2006 - "Full-length tropomyosin-related kinase B expression in the brainstem in response to persistent inflammatory pain." 06/14/2012 - "Tropomyosin-related kinase A (TrkA) is considered a promising target in the development of a therapeutic treatment of cancer and pain. " 07/01/2011 - "The authors also document that peripherally restricted antagonism of NGF-tropomyosin-related kinase A receptor signaling is effective for controlling human pain while appearing to maintain normal nociceptor function. " 03/31/2011 - "Recent studies have reported that therapies blocking nerve growth factor (NGF) or its cognate receptor, tropomyosin receptor kinase A (TrkA) are efficacious in attenuating skeletal pain. "
5.	Neoplasms (Cancer) 08/15/2013 - "This proof-of-principle study shows that it is possible to target specific actin filament populations fundamental to tumor cell viability based on their tropomyosin isoform composition. " 09/01/2007 - "To construct an eukaryotic expression vector of tumor associated gene tropomyosin 2 (TM2) tagged with green fluorescence protein and study its biological role in tumorigenesis. " 05/11/2007 - "In this study, we performed two-dimensional differentiation in-gel electrophoresis of tumors treated with anti-mir-21 and identified the tumor suppressor tropomyosin 1 (TPM1) as a potential mir-21 target. " 06/01/1997 - "The thyroid TRK oncogenes are activated by recombination with at least three different genes: the gene coding for tropomyosin and TPR, both on chromosome 1,and TFG on chromosome 3. In a previous study, we showed that two tumors carrying the TPR/NTRK1 rearrangement contained structurally different oncogenes named TRK-T1 and TRK-T2. " 12/01/2015 - "The tropomyosin isoform (Tpm) expression profile of a range of cancer cell lines (21) demonstrates that Tpm3.1 is one of the most broadly expressed Tpm isoform. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Antibodies
3.	Immunoglobulin E (IgE)
4.	Brain-Derived Neurotrophic Factor (BDNF)
5.	Nerve Growth Factor (NGF)
6.	Myosins (Myosin)
7.	Peptides
8.	calponin
9.	Antigens
10.	Adenosine Triphosphatases (ATPase)

Related Therapies and Procedures

1.	Immunotherapy
2.	Vertical Dimension (Occlusion Vertical Dimension)
3.	Traction
4.	Therapeutics
5.	Ovariectomy (Oophorectomy)