Tropoelastin

09/01/1999 - "Taken together, these data indicate that hypoxia regulates tropoelastin gene expression and may alter repair of acutely injured lung."
09/01/1999 - "Hypoxia induced early decreases in tropoelastin mRNA stability; minor suppression of gene transcription occurred later. "
09/01/1999 - "Hypoxia downregulates tropoelastin gene expression in rat lung fibroblasts by pretranslational mechanisms."
11/01/1991 - "In order to determine the direct effects of hypoxia on tropoelastin production by pulmonary artery SMC, cultured neonatal bovine pulmonary artery SMC were exposed to 3%, 10%, and 21% O2 concentrations for 48, 72, and 120 h and soluble tropoelastin was measured by direct immunoassay. "
11/01/1991 - "The primary stimulus for the increased tropoelastin production, which persists in vitro, is unknown but mechanical forces and hypoxia seem to play a role. "

03/01/1994 - "We conclude that pulmonary hypertension in the neonate perturbs the normal postpartum repression of tropoelastin expression resulting in a persistence of the fetal spacial and isoform patterns of tropoelastin gene expression."
03/01/1994 - "Neonatal hypoxic pulmonary hypertension causes increases and spatial changes in tropoelastin expression in pulmonary arteries. "
03/01/1994 - "Persistence of the fetal pattern of tropoelastin gene expression in severe neonatal bovine pulmonary hypertension."
03/01/1994 - "Thus, rather than causing a recruitment of SMC into an elastin-producing phenotype, neonatal pulmonary hypertension caused a persistence of the fetal pattern of tropoelastin expression in medial SMC. "
05/01/1992 - "The development of pulmonary hypertension in hypoxic newborn calves is associated with a complex pattern of increased tropoelastin and type I procollagen synthesis and deposition by smooth muscle cells in large elastic pulmonary arteries compared to normoxic controls. "

02/04/2000 - "IGFs stimulate vascular smooth muscle cell proliferation and migration to form the neointima and upregulate tropoelastin synthesis after disruption of the elastic layer. "
03/08/2002 - "Retrovirally mediated overexpression of versican v3 by arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointima after vascular injury."
02/01/1992 - "Immunohistochemistry demonstrated elastin protein in the neointima and in situ hybridization studies demonstrated tropoelastin mRNA largely in the neointima. "
07/15/1996 - "Tropoelastin, type I procollagen and TGF-beta gene expression, and angiotensin converting enzyme immunoreactivity, was confined to the neointima resembling the pattern of gene expression and immunoreactivity in human hypertensive elastic pulmonary artery neointimal lesions. "

08/08/2008 - "Tropoelastin regulates chemokine expression in fibroblasts in Costello syndrome."
08/01/2006 - "Significant decrease in tropoelastin gene expression in fibroblasts from a Japanese Costello syndrome patient with impaired elastogenesis and enhanced proliferation."
08/01/2006 - "In this study we demonstrated a significant decrease in the expression of tropoelastin mRNA in fibroblasts derived from a Japanese Costello syndrome patient with impaired elastogenesis and enhanced proliferation. "
03/01/2000 - "Using immunohistochemistry and metabolic labeling with [3H]-valine, we have established that cultured skin fibroblasts obtained from patients with Costello syndrome did not assemble elastic fibers, despite an adequate synthesis of tropoelastin and normal deposition of the microfibrillar scaffold. "
03/01/2000 - "Because the normal association between EBP and tropoelastin can be disrupted on contact with galactosugar-bearing moieties, and the fibroblasts from patients with Costello syndrome revealed an unusual accumulation of chondroitin sulfate-bearing proteoglycans (CD44 and biglycan), we postulate that a chondroitin sulfate may be responsible for shedding EBP from Costello cells and in turn for their impaired elastogenesis. "

04/01/1990 - "In studies directed to examining the mechanisms regulating desmoplasia in breast cancers, cell lines of human breast cancer derivation have been shown to synthesize immunoreactive tropoelastin in cell culture. "
04/11/2003 - "Lysyl oxidase (LOX) is the enzyme that cross-links extracellular collagen and tropoelastin and is involved in tumor suppressor activity. "
01/01/2007 - "Based on BLAST and secondary structure homology searches as well as motif scan analyses, provisional identification was assigned to approximately 38% (15/40) of the identified genes that have been classified into 6 groups: Ligand binding (2 insulin-like growth-factor binding, lipocalin/histamine binding), immune responsive (tumor necrosis receptor associated factor 6, Microplusin-like antimicrobial), stress response proteins (Heat shock protein [HSP] 90, HSP40, 78 kDa glucose regulated protein [GRP78]), transporter polypeptides (ABC transporter and organic anion transporter polypeptide [contains Kazal-type serine proteinase inhibitor domain]) and enzymes/regulators (extracellular matrix metaloprotease inducer, chitinase), extracellular matrix-like proteins (tropoelastin, flagelliform silk protein). "