Trioxsalen (Trioxysalen)

Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.

Also Known As:

Networked: 85 relevant articles (6 outcomes, 8 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Rantanen, T: 2 articles (06/2001 - 03/2001)
2.	Snellman, E: 2 articles (06/2001 - 03/2001)
3.	Huang, Jing: 1 article (05/2013)
4.	Wilson, David M: 1 article (05/2013)
5.	Seidman, Michael M: 1 article (05/2013)
6.	Vyjayanti, Vaddadi N: 1 article (05/2013)
7.	Baldwin, Jakita: 1 article (05/2013)
8.	Paramasivam, Manikandan: 1 article (05/2013)
9.	McNeill, Daniel R: 1 article (05/2013)
10.	Sehgal, V N: 1 article (10/2009)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2004 - "Narrowband UVB improved psoriasis clinically and statistically more efficiently than trimethylpsoralen bath PUVA, and UVB was better tolerated." 12/01/1978 - "Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis." 01/01/2004 - "The efficacy of trimethylpsoralen bath PUVA and UVB TL01 were compared in chronic plaque psoriasis. " 05/01/2004 - "Skin scales of 21 patients with psoriasis were collected by scratching after showering with trioxsalen-containing water (0.27 mg/l) for 5 min. For quantification of trioxsalen in the scales HPLC was performed. " 01/01/2004 - "Randomized half-side comparison of narrowband UVB and trimethylpsoralen bath plus UVA treatments for psoriasis."
2.	Vitiligo 05/01/1999 - "Our findings indicate that long-term oral PUVA with trioxsalen is an effective treatment for vitiligo in Taiwanese patients." 01/01/1976 - "[Treatment of vitiligo using oral Trisoralen]." 12/01/1974 - "Editorial: Effectiveness of trioxsalen therapy for vitiligo." 04/01/1974 - "Letter: Trioxsalen therapy for vitiligo." 11/01/1971 - "Oral trimethylpsoralen in vitiligo in children: a preliminary report."
3.	Skin Neoplasms (Skin Cancer) 09/01/1999 - "It has been suggested that trioxsalen bath and ultraviolet (UV) A (PUVA) is associated with a very low or no risk of non-melanoma skin cancer, but the numbers of patients in individual studies have been limited. " 10/01/1992 - "In a recently published study of 4799 Swedish patients who had received PUVA, it was noted that 833 patients who had received trioxsalen bath or oral trioxsalen did not show any increased risk of skin cancer in contrast to oral methoxsalen. " 11/01/1996 - "Systemic methoxsalen PUVA increases nonmelanoma skin cancer risk in a dose-dependent manner, whereas trioxsalen bath PUVA treatment has been suggested to be less carcinogenic. " 03/01/2001 - "Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer. "
4.	Phototoxic Dermatitis (Phototoxicity) 06/01/2001 - "This study determined the degree and persistence of phototoxicity after a single 10 min bath at a trioxysalen concentration of 0.33 mg/l. " 06/01/2001 - "Substantial phototoxicity persists up to at least 9h after the trioxysalen bath, making it wise for patients to avoid sunshine for at least the rest of the day." 01/01/1980 - "Phototoxicity of topical trioxsalen." 03/01/2001 - "Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A." 01/01/1984 - "Skin phototoxicity variations during repeated bath PUVA exposures to 8-methoxypsoralen and trimethylpsoralen."
5.	Neoplasms (Cancer) 11/01/1996 - "We performed a record linkage study of 337 male and 190 female patients with psoriasis treated with trioxsalen bath PUVA during the period 1977 to 1988 and the Finnish Cancer Registry (cancer incidence in the period 1977 to 1993). " 09/01/1999 - "In order to attain statistically relevant information about the cancer risk associated with trioxsalen bath PUVA, two follow-up studies were combined and the joined cancer incidence was analysed among 944 Swedish and Finnish patients with psoriasis. " 11/01/1996 - "Cancer incidence among Finnish patients with psoriasis treated with trioxsalen bath PUVA." 01/01/1999 - "An analysis of the epidemiological data on cancer risk following bath PUVA with trimethylpsoralen does not support the conclusion that bath PUVA per se is less carcinogenic than systemic PUVA with 8-methoxypsoralen (8-MOP). "

Related Drugs and Biologics

1.	Ficusin (Psoralen)
2.	Thymidine Monophosphate (TMP)
3.	Methoxsalen (Oxsoralen)
4.	DNA (Deoxyribonucleic Acid)
5.	5-methoxypsoralen (bergapten)
6.	Trioxsalen (Trioxysalen)
7.	Psoralens
8.	Etretinate
9.	A-Form DNA (A-DNA)
10.	Hypoxanthine

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Baths
3.	PUVA Therapy
4.	Oral Administration
5.	Transplants (Transplant)