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Trimipramine (Surmontil)

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Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.

Also Known As:

Surmontil; 10,11 Dihydro-N,N,beta-trimethyl-5H-dibenz(b,f)azepine-5-propanamine; AWD.pharma Brand of Trimipramine Maleate; Apo-Trimip; Apotex Brand of Trimipramine Maleate; Aventis Brand of Trimipramine; Aventis Brand of Trimipramine Maleate; Azupharma Brand of Trimipramine Maleate; Eldoral; Herphonal; Hexal Brand of Trimipramine; Merck dura Brand of Trimipramine Maleate; Neuro Hexal Brand of Trimipramine Maleate; Novo-Tripramine; Novopharm Brand of Trimipramine Maleate; Nu-Pharm Brand of Trimipramine Maleate; Nu-Trimipramine; Odyssey Brand of Trimipramine Maleate; Rhodiapharm Brand of Trimipramine Maleate; Rhone-Poulenc Rorer Brand of Trimipramine Maleate; Rhotrimine; Stadapharm Brand of Trimipramine Maleate; Stangyl; Surmontil Maleate; Temmler Brand of Trimipramine Maleate; Trimidura; Trimineurin; Trimineurin Maleate; Trimipramin AZU; Trimipramin Stada; Trimipramin beta; Trimipramin-neurazpharm; Trimipramine Maleate; Trimipramine Maleate (1:1); Trimipramine Maleate (1:1), (+)-Isomer; Trimipramine Maleate (1:1), (+-)-Isomer; Trimipramine Maleate (1:1), (-)-Isomer; Trimipramine Mesylate; Trimipramine Monohydrochloride; Trimipramine, (+-)-Isomer; Trimipramine, (-)-Isomer; betapharm Brand of Trimipramine Maleate; neurazpharm Brand of Trimipramine Maleate; Apo Trimip; ApoTrimip; Novo Tripramine; NovoTripramine; Nu Pharm Brand of Trimipramine Maleate; Nu Trimipramine; NuTrimipramine; Rhone Poulenc Rorer Brand of Trimipramine Maleate; Trimipramin neurazpharm; Trimipramine Aventis Brand; Trimipramine Hexal Brand; Trimipraminneurazpharm; Trimeprimine; 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-

Networked: 111 relevant articles (13 outcomes, 18 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 3-Ring Heterocyclic Compounds
  - Dibenzazepines: 2
    - Trimipramine: 111

Experts

1.	Fischer, W: 2 articles (03/2003 - 09/2002)
2.	Berger, M: 2 articles (03/2003 - 09/2002)
3.	Kupferschmidt, H: 1 article (07/2014)
4.	Reichert, P: 1 article (07/2014)
5.	Reichert, C: 1 article (07/2014)
6.	Monnet-Tschudi, F: 1 article (07/2014)
7.	Ceschi, A: 1 article (07/2014)
8.	Rauber-Lüthy, C: 1 article (07/2014)
9.	Sung, K C: 1 article (03/2013)
10.	Chen, Su-Jong: 1 article (03/2013)

Related Diseases

1.	Sleep Initiation and Maintenance Disorders (Insomnia) 05/30/2009 - "Trimipramine is a sedating tricyclic antidepressant which is not only effective in the treatment of depression but also in primary insomnia. " 01/01/1996 - "Trimipramine is of particular value in depressed patients with insomnia, and it has been shown to be effective in the therapy of primary insomnia. " 01/01/1989 - "Trimipramine is effective in depressed patients with chronobiological disorders such as chronic insomnia, although its mechanism of action is not fully understood." 09/01/2002 - "This first double-blind placebo-controlled study with trimipramine suggests its efficacy in the treatment of primary insomnia. " 09/01/2002 - "Trimipramine was selected since it has shown positive effects on sleep continuity with a lack of REM sleep suppression in studies on depressed patients and in one pilot study on patients with primary insomnia. "
2.	Duodenal Ulcer (Curling's Ulcer) 04/01/1984 - "Trimipramine in chronic duodenal ulcer: a double blind controlled study." 11/15/1980 - "Double-blind trial of trimipramine in the treatment of duodenal ulcer." 01/01/1985 - "Polycyclic drugs such as the dibenzazapine trimipramine have been shown to accelerate the healing of gastric and duodenal ulcers, possibly by inhibiting gastric secretion. " 05/01/1984 - "Thus maintenance treatment with trimipramine proved no better than placebo in preventing relapses of duodenal ulcers. " 04/01/1983 - "[Treatment of duodenal ulcer with trimipramine. "
3.	Sleep Deprivation 07/01/1994 - "The present study was designed to investigate the clinical efficacy of trimipramine with adjunct sleep deprivation (SD) or bright light (BL) and to evaluate psychometric and neurobiological variables that might be of predictive value for treatment response. " 07/01/1995 - "2. Polysomnographic sleep (PSG) data and self reported sleep measures were assessed at baseline and after one week in 18 patients (35-65 years) randomly assigned to treatment with either trimipramine alone 200 mg/d (group 1) or trimipramine (200 mg/d) and additional serial partial sleep deprivation in the second half of the night (3x/week) (group 2). " 01/01/1994 - "Trimipramine, sleep deprivation and light]."
4.	Schizophrenia (Dementia Praecox) 01/01/1991 - "Since both have the same affinity for the D2 receptor and since the affinity for this receptor correlates closely with the antipsychotic potency of a drug, an antipsychotic efficacy of trimipramine in acute schizophrenia could be expected. " 09/01/1990 - "High-dose trimipramine in acute schizophrenia. " 01/01/1967 - "[Clinical use of Trimipramine for schizophrenia--for idleness and insensibility]." 03/01/2003 - "Ninety-five patients with acute schizophrenia (DSM-III-R) and a BPRS total score > 40 at baseline were treated with either 300-400 mg trimipramine or 450-600 mg perazine for 5 weeks. "
5.	Bipolar Disorder (Mania) 09/01/1999 - "It is concluded that, at least in the case of trimipramine, the pharmacologic profile is not helpful in predicting potential effectiveness in mania." 04/01/1987 - "An adolescent patient with a history of progressively more severe seasonal depression subsequently developed a refractory manic-depressive psychosis with rapid cycling after the initiation of treatment with trimipramine. "

Related Drugs and Biologics

1.	Trimipramine (Surmontil)
2.	Cimetidine (Biomet)
3.	Antidepressive Agents (Antidepressants)
4.	lormetazepam
5.	Cytochrome P-450 CYP2D6 (CYP2D6)
6.	Diazepam (Valium)
7.	Doxepin (Mareen)
8.	Imipramine (Janimine)
9.	Histamine (Histamine Dihydrochloride)
10.	Amitriptyline (Elavil)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Phototherapy (Light Therapy)
3.	Ligation