Trimethoprim (Proloprim)

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.

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Networked: 2082 relevant articles (183 outcomes, 198 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Yaguchi, Takashi: 3 articles (07/2022 - 01/2020)
2.	Tong, Steven Y C: 3 articles (09/2021 - 04/2016)
3.	Brauner, Bernhard: 3 articles (07/2020 - 04/2020)
4.	Gabor, Franz: 3 articles (07/2020 - 04/2020)
5.	Wirth, Michael: 3 articles (07/2020 - 04/2020)
6.	Gajdács, Márió: 3 articles (04/2020 - 01/2019)
7.	Urbán, Edit: 3 articles (04/2020 - 01/2019)
8.	Soejima, Makoto: 3 articles (01/2020 - 01/2007)
9.	Huang, David B: 3 articles (03/2019 - 11/2018)
10.	Cormican, Martin: 3 articles (01/2019 - 07/2010)

Related Diseases

1.	Infections 04/01/2009 - "However, several eukaryotic pathogenic organisms are resistant to trimethoprim, preventing its effective use as a therapeutic for those infections. " 08/01/1981 - "Ninety-six elderly patients (mean age 80 years) with acute urinary infections were treated in a single-blind trial, with either one 200 mg dose of trimethoprim or 200 mg b.d. " 11/01/1969 - "Bacteriological, pharmacological and clinical studies with trimethoprim-sulphonamide combinations with particular reference to the treatment of urinary infections." 03/01/1969 - " studies showed that many bacteria causing urinary infections in hospital were sensitive to trimethoprim, and the therapeutic results could have been largely predicted from a knowledge of the in-vitro sensitivity tests to trimethoprim alone. " 05/01/2021 - "Interviewing patients & documenting relevant data from hospital electronic Medical records (EMR), followed by comparison of Incidence densities of major infections between those on prophylactic Trimethoprim 160 mg + Sulfamethoxazole 800 mg and those not on it, was done by student 't' test. "
2.	Urinary Tract Infections (Urinary Tract Infection) 06/01/1991 - "The efficacy of single dose treatment with trimethoprim compared to a 5-day course with the same drug was investigated in 100 children, 3-12 years, with isolated episodes of symptomatic non-febrile urinary tract infection. " 06/01/2001 - "The objective of this study was to evaluate the association between exposure to community-prescribed trimethoprim and other risk factors in subjects and subsequent trimethoprim-resistant urinary tract infection. " 02/01/1988 - "In the first study to assess the effect of trimethoprim in the treatment of acute urinary tract infections in children, we compared it with sulphisoxazole. " 03/01/1981 - "Studies concerning the treatment of urinary tract infections with trimethoprim alone are reviewed and results of the treatment of acute urinary tract infection with a single dose of trimethoprim at St Radboud Hospital are presented." 12/01/2022 - "NHS Lothian policy has recently changed to avoid first-line use of trimethoprim for uncomplicated urinary tract infections (UTI) in patients with risk factors for trimethoprim resistance, in line with national guidance. "
3.	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 01/31/2019 - "Life-threatening hyperkalaemia due to trimethoprim in a patient treated for Pneumocystis jirovecii pneumonia." 05/01/2005 - "Pneumocystis carinii pneumonia (PCP) is usually prevented in transplanted patients by prophylactic trimethoprim-sulfamethoxazol (TMS). " 08/01/1997 - "A population pharmacokinetic model of trimethoprim in patients with pneumocystis pneumonia, made with parametric and nonparametric methods." 08/01/1991 - "Thirty-seven children were prescribed trimethoprim-sulfametoxazole as a prophylaxis for Pneumocystis carinii pneumonia.(ABSTRACT TRUNCATED AT 250 WORDS)" 10/01/1988 - "Two patients developed Pneumocystis carinii pneumonia, which was treated successfully in one patient with intravenous sulphadimidine and trimethoprim. "
4.	Pneumonia (Pneumonitis) 04/01/1996 - "carinii pneumonitis without trimethoprim." 10/01/1984 - "A double-blind comparative study of trimethoprim versus trimethoprim-sulphamethaxazole combination in pneumonia." 01/01/2008 - "Preventive effect of sulfamethoxasole-trimethoprim on Pneumocystis jiroveci pneumonia in patients with interstitial pneumonia." 02/01/1990 - "He suffered from pneumonia with marked improvement on sulfamethoxazole-Trimethoprim. " 03/01/1974 - "A combination of trimethoprim and sulfamethoxazole was effective in the prevention and treatment of Pneumocystis carinii pneumonitis in cortisonetreated rats. "
5.	Typhoid Fever (Typhoid) 01/01/1985 - "It is therefore our opinion that treatment of typhoid fever with a sulfa-trimethoprim combination is both effective and safe." 06/01/1987 - "Trimethoprim in enteric fever." 08/01/1986 - "Trimethoprim alone is a suitable agent for the treatment of enteric fever." 08/01/1986 - "Trimethoprim in enteric fever." 01/31/1981 - "Trimethoprim in enteric fever."

Related Drugs and Biologics

1.	Sulfamethoxazole
2.	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)
3.	Anti-Bacterial Agents (Antibiotics)
4.	Ampicillin (Omnipen)
5.	Thymidine Monophosphate (TMP)
6.	Sulfadiazine (Sulphadiazine)
7.	Rifampin (Rifampicin)
8.	Chloramphenicol (Chloromycetin)
9.	Dapsone
10.	Ciprofloxacin (Cipro)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Chemoprevention
5.	Oral Administration