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Trihexyphenidyl (Artane)

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One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.

Also Known As:

Artane; AHP Brand of Trihexyphenidyl Hydrochloride; Apo-Trihex; Apotex Brand of Trihexyphenidyl Hydrochloride; Aventis Brand of Trihexyphenidyl Hydrochloride; Cyclodol; Cypress Brand of Trihexyphenidyl Hydrochloride; Eisai Brand of Trihexyphenidyl Hydrochloride; Hexal Brand of Trihexyphenidyl Hydrochloride; Hipokinon; Lederle Brand of Trihexyphenidyl Hydrochloride; Liquipharm Brand of Trihexyphenidyl Hydrochloride; Parkinane; Parkopan; Pharmaceutical Associates Brand of Trihexyphenidyl Hydrochloride; Psicofarma Brand of Trihexyphenidyl Hydrochloride; Rugby Brand of Trihexyphenidyl Hydrochloride; Schrein Brand of Trihexyphenidyl Hydrochloride; Trihexane; Trihexidyl Hydrochloride; Trihexyphenidyl Hydrochloride; Trihexyphenidyl Hydrochloride Elixir; Wyeth Brand of Trihexyphenidyl; Wyeth Brand of Trihexyphenidyl Hydrochloride; Apo Trihex; ApoTrihex; Trihexyphenidyl Wyeth Brand; Benzhexol; 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-

Networked: 249 relevant articles (35 outcomes, 21 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Piperidines: 12
    - Trihexyphenidyl: 249

Experts

1.	Yokoi, Fumiaki: 2 articles (06/2013 - 01/2012)
2.	Li, Yuqing: 2 articles (06/2013 - 01/2012)
3.	Ben-Pazi, Hilla: 2 articles (07/2011 - 07/2006)
4.	Ji, Bian-Sheng: 2 articles (12/2010 - 05/2008)
5.	Kuwabara, Y: 2 articles (07/2001 - 04/2000)
6.	Nakagawa, M: 2 articles (07/2001 - 04/2000)
7.	Yamada, T: 2 articles (07/2001 - 04/2000)
8.	Ohyagi, Y: 2 articles (07/2001 - 04/2000)
9.	Kira, J: 2 articles (07/2001 - 04/2000)
10.	Chen, Pei-Jung: 1 article (12/2015)

Related Diseases

1.	Dystonia (Limb Dystonia) 10/01/1992 - "The action dystonia was markedly improved by giving trihexyphenidyl. " 02/01/1986 - "Thirty-seven per cent of the 35 idiopathic dystonia patients had a moderate to marked improvement with an average dosage of 21.5 mg of trihexyphenidyl. " 07/01/2011 - "The author hypothesized that trihexyphenidyl may be more effective in specific subgroups and performed a retrospective analysis of 31 children (8.2 ± 5.8 years) with dystonia following treatment with high-dose trihexyphenidyl (>0.5 mg/kg/day). " 09/01/1996 - "Response to medical treatment (trihexyphenidyl dose as high as 40 mg daily) in 5 patients was disappointing; 4 of the 5 patients who underwent functional stereotaxic operations were improved, but dystonia was still present at the end of the follow-up. " 08/01/1999 - "The symptoms abated under therapy with trihexyphenidyl-HCL, so that the patient has been able to work as a tennis coach with improved athletic performance for the past 3 yr. It is concluded that the various forms of dystonia should be included in the differential diagnosis of impaired coordinative movements under athletic exercise, especially of the upper extremities."
2.	Tremor (Tremors) 06/01/2012 - "However, he was eventually placed on trihexyphenidyl which contributed to a 70% improvement in his tremor. " 11/15/2007 - "We report on a patient who developed left arm rest/postural tremor at age 24 and responded well to trihexyphenidyl. " 03/01/2006 - "The tremor was successfully controlled by a single high daily dose of trihexyphenidyl (38 mg) without severe or uncomfortable side effects. " 01/01/2003 - "Re-administration of trihexyphenidyl decreased the tremors. " 01/01/2003 - "Ten weeks after the accident, a coarse tremor in the head and right upper extremity developed after withdrawal of trihexyphenidyl. "
3.	Parkinsonian Disorders (Parkinsonism) 08/27/1949 - "Artane therapy for parkinsonism; a preliminary study of results in 117 cases." 11/01/2003 - "NYG has obvious efficacy enhancing and toxicity attenuating effects caused by the anti-Parkinsonism treatment with Medopa and Artane." 11/01/2003 - "Adopting the randomized double-blinded method, the effect of adding NYG to 30 patients with Parkinsonism in the treated group, who already received anti-Parkinsonism treatment but showing decreased response to Medopa and Artane and with obvious adverse reaction, was observed and controlled by 30 patients treated by adding placebo. " 11/09/1967 - "[Treatment of parkinsonism with benzhexole (Artane and Artane-sequel)]." 11/01/1966 - "Treatment of parkinsonism with artane and slow release artane."
4.	Cerebral Palsy (Spastic Diplegia) 11/01/2014 - "Further studies will be necessary to prove the efficacy of trihexyphenidyl for dyskinetic cerebral palsy." 11/01/2014 - "In this study we evaluated a cohort of 47 patients affected by dyskinetic cerebral palsy and treated with anticholinergic drug (trihexyphenidyl) over one year in order to verify the responsiveness of the new scale. " 07/01/2011 - "Trihexyphenidyl improves motor function in children with dystonic cerebral palsy: a retrospective analysis." 03/01/2011 - "Use of trihexyphenidyl in children with cerebral palsy." 05/01/2007 - "The authors conclude that scientific evidence for the clinical use of trihexyphenidyl in cerebral palsy remains equivocal. "
5.	Parkinson Disease (Parkinson's Disease) 07/01/1985 - "Although trihexyphenidyl has been used effectively for many years in the treatment of Parkinson's disease, little is known about its pharmacokinetics. " 06/01/1984 - "In this study the anticholinergic drug, trihexyphenidyl, at low doses when administered chronically for one month to Parkinson disease patients caused a decrease in performance on recent but not immediate memory tests. " 01/01/1991 - "Thirteen patients with idiopathic Parkinson's disease of recent onset (mean age 63·2 years) and a group of 10 young healthy volunteers (mean age 26·1 years) underwent a series of neuropsychological tests for assessment of memory, learning ability and mental processing speed before and during treatment with trihexyphenidyl. " 01/01/1991 - "Effects of treatment with trihexyphenidyl on cognitive function in early Parkinson's disease." 05/01/1988 - "Adverse effect of benzhexol on memory in Parkinson's disease."

Related Drugs and Biologics

1.	Levodopa (L Dopa)
2.	Trihexyphenidyl (Artane)
3.	Biperiden (Akineton)
4.	Amantadine (Aman)
5.	Benztropine (Benzatropine)
6.	Tetrabenazine (Nitoman)
7.	Botulinum Toxins (Botulinum Toxin)
8.	Scopolamine (Hyoscine)
9.	Clozapine (Clozaril)
10.	Procyclidine (Procyclidine Hydrochloride)

Related Therapies and Procedures

1.	Injections
2.	Oral Administration
3.	Deep Brain Stimulation
4.	Psychology Biofeedback (Biofeedback)
5.	Analgesia