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Triethylenemelamine (Tretamine)

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Toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers.

Also Known As:

Tretamine; 2,4,6-Triethylimino-1,3,5-Triazine; Triethylene Melamine; Melamine, Triethylene; 1,3,5-Triazine, 2,4,6-tris(1-aziridinyl)-

Networked: 104 relevant articles (2 outcomes, 3 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Triazines: 37
    - Triethylenemelamine: 104
  - Azirines
    - Aziridines: 11
      - Triethylenemelamine: 104

Related Diseases

1.	Hodgkin Disease (Hodgkin's Disease) 03/01/1960 - "[A case of Hodgkin's disease of the small intestine which was operated on, recurred and treated with triethylene melamine]." 10/01/1959 - "[An operated case of Hodgkin's disease of the small intestine, recurred and treated with triethylene melamine]." 09/08/1955 - "[Triethylene melamine in Hodgkin's disease]." 06/01/1953 - "[Treatment of Hodgkin's disease with triethylene melamine; preliminary report]." 04/01/1953 - "Observations on the use of triethylene melamine in Hodgkin's disease."
2.	Shock 07/01/1988 - "Heat shock (10 min 40 degrees C) prior to challenge treatment with triethylenemelamine (TEM) or maleic hydrazide (MH) significantly reduced the frequency of induced chromatid aberrations in Vicia faba main root meristems. " 07/01/1988 - "Effects of novobiocin on heat shock protection against chromatid aberration induction by triethylenemelamine (TEM) and maleic hydrazide (MH) in Vicia faba."
3.	Chromosome Aberrations (Chromosome Abnormalities) 02/01/1982 - "Dose- and time-response relationships of triethylenemelamine-induced chromosomal aberrations in rat bone marrow cells." 02/01/1978 - "The production of chromosome aberrations in various mammalian cells by triethylenemelamine." 01/01/1977 - "Chromosome aberrations and dominant lethality of mouse embryos after paternal treatment with triethylenemelamine." 01/01/1977 - "Delayed formation of chromosome aberrations in mouse pachytene spermatocytes treated with triethylenemelamine (TEM)." 07/01/1974 - "DNA repair synthesis and chromosomal aberrations induced in vivo by triethylenemelamine."
4.	Lung Neoplasms (Lung Cancer) 04/01/1961 - "Clinical trials with Tretamine (T.E.M.) in inoperable lung cancer." 01/23/1960 - "Tretamine in the treatment of inoperable lung cancer." 10/21/1961 - "Tretamine compared with nitrogen mustard in the palliation of inoperable lung cancer."
5.	Polycythemia Vera 03/01/1953 - "Triethylenemelamine in polycythemia vera; a therapeutic trial." 09/01/1952 - "Treatment of polycythemia vera with triethylene melamine; summary of thirty cases."

Related Drugs and Biologics

1.	Mechlorethamine (Nitrogen Mustard)
2.	Novobiocin (Streptonivicin)
3.	Maleic Hydrazide
4.	Dimethyl Sulfoxide (DMSO)
5.	Aminopterin
6.	Mitomycin (Mitomycin-C)
7.	Urethane (Ethyl Carbamate)
8.	Triethylenemelamine (Tretamine)
9.	Thiotepa (Triethylenethiophosphoramide)
10.	Altretamine (Hemel)

Related Therapies and Procedures

1.	Intravenous Injections
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy
4.	Intra-Arterial Infusions
5.	Aftercare (After-Treatment)