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Tricuspid Valve Insufficiency (Insufficiency, Tricuspid Valve)

Subscribe to New Research on Tricuspid Valve Insufficiency

Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.

Also Known As:

Insufficiency, Tricuspid Valve; Tricuspid Valve Regurgitation; Incompetence, Tricuspid; Incompetence, Tricuspid Valve; Regurgitation, Tricuspid; Regurgitation, Tricuspid Valve; Valve Incompetence, Tricuspid; Valve Insufficiency, Tricuspid; Valve Regurgitation, Tricuspid; Tricuspid Incompetence; Tricuspid Regurgitation; Tricuspid Valve Incompetence

Networked: 626 relevant articles (21 outcomes, 57 trials/studies)

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 37259
- Heart Diseases: 18762
  - Heart Valve Diseases: 960
    - Tricuspid Valve Insufficiency: 626

Related Diseases

1.	Mitral Valve Insufficiency (Mitral Regurgitation)
2.	Pulmonary Hypertension (Ayerza Syndrome)
3.	Heart Failure
4.	Dyspnea (Shortness of Breath)
5.	Pathologic Constriction (Stenosis)

Experts

1.	Kato, Gregory J: 10 articles (07/2013 - 01/2009)
2.	Nouraie, Mehdi: 10 articles (07/2013 - 01/2009)
3.	Gladwin, Mark T: 10 articles (07/2013 - 01/2009)
4.	Castro, Oswaldo L: 9 articles (07/2013 - 01/2009)
5.	Gordeuk, Victor R: 9 articles (07/2013 - 01/2009)
6.	Dham, Niti: 8 articles (07/2013 - 01/2009)
7.	Minniti, Caterina P: 7 articles (07/2013 - 01/2009)
8.	Sable, Craig: 7 articles (07/2013 - 01/2009)
9.	Ensing, Gregory: 6 articles (07/2013 - 11/2009)
10.	Rana, Sohail: 6 articles (07/2013 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tricuspid Valve Insufficiency:

1.	sildenafil (Viagra)FDA Link 01/01/2005 - "Forty-eight hours after sildenafil treatment, echocardiography revealed that the tricuspid incompetence was substantially diminished and the contractility of both ventricles improved, indicating a marked reduction in pulmonary arterial pressure. " 11/01/2007 - "Peak tricuspid regurgitation flow velocities did not change significantly with the treatment of sildenafil, but selected systolic time intervals were significantly improved. " 04/01/2005 - "An echocardiogram obtained 2 months after starting sildenafil therapy showed normal right cavities, previously dilated, as well as minimal protosystolic tricuspid regurgitation without PH. A new right hemodynamic study performed after 4 months showed a reduction in pulmonary vascular resistance, from 8 U to 3.5 U Woods. " 09/01/2015 - "Clinical scores, pulmonary alveolar infiltrate scores and tricuspid regurgitation gradients were analyzed PRE and POST sildenafil. " 07/01/2010 - "We aimed to assess the acute cardiopulmonary effects of a 100-mg oral single dose of sildenafil in patients with idiopathic pulmonary hypertension (IPAH) using a well-validated but less-used noninvasive echocardiographic method for the measurement of both systolic and diastolic pulmonary artery pressure (PAP), by tricuspid regurgitation (TR) velocity curve analysis. "
2.	Brain Natriuretic Peptide (Natrecor)FDA Link 01/01/2015 - "Three patients (20%) presented with completely normal echocardiography, absent tricuspid regurgitation, and normal pro-brain natriuretic peptide levels, indicative of 'hemodynamic remission'. " 08/01/2009 - "The study included stable adult patients after atrial switch, stratified according to preserved versus impaired systolic function (fractional area change > or =0.40 vs <0.40), absence versus presence of symptoms, absence versus presence of significant tricuspid regurgitation (TR), and normal versus elevated brain natriuretic peptide (BNP) levels. " 12/01/2010 - "B-type natriuretic Peptide in isolated severe tricuspid regurgitation: determinants and impact on outcome." 11/01/2005 - "There was no deterioration in cardiothoracic ratio, human atrial natriuretic peptide, brain natriuretic peptide levels, tricuspid regurgitation, RV Tei index and pulse oximeter saturation. " 11/01/2005 - "Cardiothoracic ratio, NYHA class, heart rate, pulse oximeter saturation, plasma levels of human atrial natriuretic peptide and brain natriuretic peptide, tricuspid regurgitation, and right ventricular myocardial index (RV Tei index) were evaluated by echocardiography, lower extremity muscle strength, ambulation ability, Barthel index, and 6-minute walking distance at the beginning and end of cardiopulmonary rehabilitation. "
3.	Dobutamine FDA LinkGeneric 11/01/2011 - "A novel hemodynamic observation: worsening of tricuspid regurgitation with dobutamine infusion during a hemodynamic study." 11/01/2011 - "However, the effect of dobutamine in the select group of patients with severe tricuspid regurgitation (TR) has not been described previously. " 04/01/1986 - "Infusion of dobutamine increased the size of the a-loop relative to the v-loop both at baseline and after induction of tricuspid regurgitation. " 10/01/2005 - "Hypoxia and dobutamine increased cardiac output and tricuspid regurgitation velocity. " 03/01/2008 - "Transthoracic echocardiography showed left ventricular dysfunction (EF = 20%), with mitral regurgitation 2-3+, tricuspid regurgitation 3+, and estimated systolic right ventricular pressure of 53 mm Hg. Inotropic drug, dobutamine, was initiated, which led to significant improvement of hemodynamic parameters. "
4.	Colloids (Colloid)IBA 04/01/2002 - "Agitated colloid is superior to saline and equivalent to levovist in enhancing tricuspid regurgitation Doppler envelope and in the opacification of right heart chambers: a quantitative, qualitative, and cost-effectiveness study." 05/01/2014 - "Extramedullary pulmonary hematopoiesis causing pulmonary hypertension and severe tricuspid regurgitation detected by technetium-99m sulfur colloid bone marrow scan and single-photon emission computed tomography/CT." 05/01/2014 - "We report the case of a 66-year-old man with known primary myelofibrosis, in whom a Technetium-99m sulfur colloid bone marrow scan with single-photon emission computed tomography (SPECT)/CT revealed a pulmonary hematopoiesis as the cause of pulmonary hypertension and severe tricuspid regurgitation. "
5.	SHU 508 (Levovist)IBA 08/01/2002 - "In case of weak or poor Doppler signals, measurable tricuspid regurgitation and pulmonary venous flow tracings were obtained after intravenous administration of 2.5 grams of Levovist at 400 mg/ml. At baseline, left ventricular ejection fraction was 30% +/- 7% and pulmonary artery systolic pressure was 48 +/- 14 mmHg. " 04/01/2002 - "Agitated colloid is superior to saline and equivalent to levovist in enhancing tricuspid regurgitation Doppler envelope and in the opacification of right heart chambers: a quantitative, qualitative, and cost-effectiveness study."
6.	Carbon MonoxideIBA 05/01/2010 - "Tricuspid regurgitation grades III-IV was successfully created in all animals and resulted in a significant reduction of CO. " 04/01/2013 - "Thirty-eight patients with SSc were studied, using a cycloergometer protocol; 10 were excluded due to resting PH or absence of tricuspid regurgitation (TR); TR and mitral E-wave velocities, LV outflow tract time-velocity integral and LV septal E'-wave were measured before and in peak exercise to calculate cardiac output (CO), PCWP and pulmonary vascular resistance (PVR). " 08/01/2010 - "The validity of measuring cardiac output (CO) using thermodilution via pulmonary artery catheterization in the presence of tricuspid regurgitation (TR) remains controversial. " 05/01/2010 - "Severe tricuspid regurgitation (TR) reduces cardiac output (CO) and increases central venous pressure leading to secondary organ dysfunction. " 05/01/1999 - "Tricuspid valve regurgitation, SV, HR and CO were significantly higher in athletes than in nonathletes over all workloads, including rest. "
7.	Coenzyme A (CoA)IBA 04/20/2015 - "No patient required further surgery because of a CoA; (2) in two cases, an aortic aneurysm was found with an angiogram performed immediately postdilatation and disappeared at 18 and 12 months of age, respectively; (3) tricuspid regurgitation and pulmonary hypertension improved in all patients; (4) all patients were doing well and were asymptomatic. "
8.	trastuzumab (Herceptin)FDA Link 09/01/2010 - " sixth patient was diagnosed with a newly developed tricuspid valve insufficiency grade 3. Follow-up data of 20 months since the start of trastuzumab treatment showed that 27 patients were disease-free. "
9.	imatinib (Gleevec)FDA Link 03/07/2015 - "Imatinib therapy was also associated with significant reduction in peak tricuspid regurgitation velocity, increase in LV size, and improvement in LV early diastolic relaxation velocity. "
10.	beraprostIBA 01/01/2006 - "We judged that beraprost sodium was effective when at least two of the following conditions were met: improvement in symptom of dyspnea, more than 10% decrease in peak velocity of tricuspid valve regurgitation by echocardiography (Vmax), or more than 10% increase in 6-min walking distance. "

Therapies and Procedures

1.	Sutures (Suture) 01/01/2014 - "Concomitant tricuspid annuloplasty using flexible bands offered improved durability than suture annuloplasty for preventing postoperative tricuspid regurgitation progression." 07/01/2012 - "The question addressed was whether tricuspid valve (TV) repair with an annuloplasty ring leads to an improved outcome over a conventional suture annuloplasty for patients with severe tricuspid incompetence. " 12/01/2014 - "Ring or suture annuloplasty for tricuspid regurgitation? " 04/01/2014 - "Repair of functional tricuspid regurgitation: comparison between suture annuloplasty and rings annuloplasty." 01/01/2014 - "From univariate analysis, the risk factors for ≥moderate TR were suture annuloplasty and preoperative tricuspid regurgitation grade. "
2.	Endarterectomy (Thromboendarterectomy) 03/01/2003 - "This review analyzes the factors responsible for changes in tricuspid valve regurgitation after pulmonary endarterectomy and provides a strategy to predict the small subset of patients who will not show improvement in tricuspid valve function after this operation." 06/01/2010 - "We studied 26 patients undergoing pulmonary thromboendarterectomy without repair of tricuspid regurgitation; 24 were followed up for 7 to 59 months after surgery (mean, 33 months). " 06/01/2010 - "Improvement of tricuspid regurgitation after pulmonary thromboendarterectomy." 11/01/2007 - "In 33 patients with CTEPH (9 men, 22-76 years), changes in the tricuspid regurgitation pressure gradient (TRPG) and the acceleration time (ACT) of pulmonary artery flow (a surrogate parameter of pulmonary artery compliance) were examined before and after pulmonary thromboendarterectomy using echocardiography to clarify factors affecting the changes. " 07/07/2004 - "Because pulmonary thromboendarterectomy (PTE) can result in an immediate reduction in pulmonary artery (PA) pressure, we sought to evaluate the effect of PTE on severe tricuspid regurgitation (TR) without tricuspid annuloplasty. "
3.	Catheters 08/01/1998 - "The result has revealed that this catheter is very useful in clinical settings without causing catheter-induced tricuspid regurgitation (TR) allowing easier and safer right ventriculography as compared with conventional catheters." 01/01/2008 - "In a subgroup of 20 patients, systolic PAP measured from the pulmonary artery catheter immediately before withdrawal was compared with Doppler study of regurgitation tricuspid flow performed immediately after pulmonary artery catheter withdrawal using either the transthoracic or the transesophageal approach. " 03/01/1991 - "In conclusion, this study shows for the first time that the quantitative extent of catheter-induced tricuspid regurgitation is small, and is therefore unlikely to be important clinically, particularly with regard to the assessment of thermodilution cardiac output." 03/01/1991 - "Pulsed-wave Doppler studies showed that the incidence of catheter-induced tricuspid regurgitation was 48 percent, and that the average tricuspid regurgitation score increased from 0.41 +/- 0.16 to 0.61 +/- 0.17 (p less than 0.01). " 09/01/1981 - "Intracardiac phonocardiograms were obtained from the right atrium in order to study the relation between the clinical signs of tricuspid regurgitation, intracardiac murmurs and the degree of regurgitation demonstrated on right ventriculography with use of a preshaped catheter. "
4.	Prostheses and Implants (Prosthesis) 02/01/2002 - "In the presence of significant tricuspid regurgitation, steroid-eluting active-fixation leads should be used routinely, and in patients with a tricuspid prosthesis, the use of a dedicated cardiac venous pacing system is likely to be the best option." 10/01/2015 - "The development of a transcatheter tricuspid valve prosthesis for the treatment of tricuspid regurgitation (TR) is presented. " 01/01/2013 - "There are ongoing controversies as to the optimal surgical management of TV disease, including repair versus replacement, the type of prosthesis preferred, optimal repair techniques, appropriate management of functional tricuspid regurgitation (TR) with concomitant left heart valve surgery, and others. " 06/01/2006 - "From June 2002 to November 2004, 75 patients with functional tricuspid regurgitation (mean, 3.1 +/- 0.9) underwent tricuspid valve repair with this new prosthesis. " 05/01/2000 - "The suggested mechanism is the association of a residual shunt with flow of tricuspid regurgitation, impinging on the inferior edge of the prosthesis, factors which should be taken into consideration during the implantation of this type of device."
5.	Transplantation (Transplant Recipients) 06/01/2014 - "Aims of the study were (1) to estimate the prevalence of DD among LTx candidates, (2) to compare outcome between patients with and without DD, and (3) to determine if tricuspid regurgitation (TR) is a predictor of post-transplantation outcome. " 05/01/2003 - "The purpose of this study was to quantitate abnormalities in tricuspid annular systolic and diastolic velocities as an indicator of RV dysfunction, and to evaluate if time since transplantation and the presence of tricuspid regurgitation are associated with quantitative changes in tricuspid annular velocities in pediatric heart transplant recipients. " 01/01/2014 - "The RHD patients had a lower 15-year survival rate than the DCM patients after transplantation (22.7% vs. 45.7%, P=0.038) and higher incidence of tricuspid regurgitation than the control group (32.2% vs. 11.4%). " 08/01/2011 - "Early post-operative RHF results in poorer survival/progression to transplantation for BTT patients and is predicted by greater pre-operative tricuspid incompetence. " 05/01/2007 - "Tricuspid regurgitation prevalence diminished from 55% to 19% with reduction in severity 1 year after transplantation. "