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Trichlorfon (Metrifonate)

An organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is also used in anthelmintic compositions for animals. (From Merck, 11th ed)
Also Known As:
Metrifonate; Bilarcil; Chlorofos; Dipterex; Dylox; Foschlor; Metriphonate; Neguvon; Ricifon; Trichlorphon; Chlorophos; Phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester
Networked: 376 relevant articles (39 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Cyrus, P A: 4 articles (01/2001 - 01/2000)
2. Pohanka, Miroslav: 3 articles (10/2011 - 06/2009)
3. Bhushan, Chandra: 3 articles (08/2011 - 12/2009)
4. Baldissera, Matheus D: 2 articles (12/2020 - 04/2019)
5. Baldisserotto, Bernardo: 2 articles (12/2020 - 04/2019)
6. Prestes, Osmar D: 2 articles (12/2020 - 04/2019)
7. Souza, Carine F: 2 articles (12/2020 - 04/2019)
8. Zanella, Renato: 2 articles (12/2020 - 04/2019)
9. da Silva, Aleksandro S: 2 articles (12/2020 - 04/2019)
10. Soares-Weiser, Karla: 2 articles (01/2018 - 11/2004)

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
2. Body Weight (Weight, Body)
04/19/2006 - "Metrifonate at various doses, fixed and loading doses, was associated with significant cognitive improvement compared to placebo, except for weekly doses where there was no difference from placebo: MMSE (metrifonate 60-80 mg/day with initial loading at 26 weeks; metrifonate 50 mg/day fixed dose with no initial loading at 26 weeks MD 1.85, 95% CI 1.06 to 2.64, p<0.00001); ADAS-Cog (metrifonate 60-80 mg/day with initial loading at 26 weeks MD -3.24, 95% CI -4.40 to -2.08, p<0.00001)In most trials, there was improvement in clinical global impression: CIBIC-Plus (metrifonate 30-55 mg/day, approximately 0.65 mg/kg body weight, with initial loading at 26 weeks MD -0.25, 95% CI -0.41 to -0.09 p=0.002; metrifonate 50 mg/day fixed dose with no initial loading at 26 weeks MD -0.20, 95% CI -0.39 to -0.01, p=0.04). "
04/01/1984 - "Thus, trichlorfon given three or four times in a dose of 10 mg/kg of body weight spaced over a period of two years was highly effective in reducing parasite load and disease in children living under hyperendemic conditions."
10/01/1966 - "A dose of trichlorphon, 100 mg./kg. of body weight, was effective and safe. "
10/01/2011 - "Wistar rats (six per group) were exposed subcutaneously to either 60 or 120 mg/kg of body weight of metrifonate and compared with the controls treated with saline only. "
07/01/2009 - "The lack of effects of trichlorfon on any in vivo reproductive and fetuses endpoints above suggested that for trichlorfon, a hazard of reproductive toxicity below 50 mg/kg body weight/d maybe not expected. "
3. Infections
4. Schistosomiasis haematobia (Schistosomiasis haematobium)
5. Schistosomiasis (Bilharziasis)

Related Drugs and Biologics

1. Cholinesterase Inhibitors (Anticholinesterases)
2. Praziquantel (Biltricide)
3. Donepezil (Aricept)
4. Rivastigmine (Exelon)
5. Tacrine (Cognex)
6. Dichlorvos
7. Oxamniquine
8. Acetylcholinesterase
9. Organophosphates
10. Enzymes

Related Therapies and Procedures

1. Activities of Daily Living (ADL)
2. Drug Therapy (Chemotherapy)
3. Therapeutics
4. Institutionalization (Institutionalized Persons)
5. Oral Administration