Trichinellosis

An infection with TRICHINELLA. It is caused by eating raw or undercooked meat that is infected with larvae of nematode worms TRICHINELLA genus. All members of the TRICHINELLA genus can infect human in addition to TRICHINELLA SPIRALIS, the traditional etiological agent. It is distributed throughout much of the world and is re-emerging in some parts as a public health hazard and a food safety problem.

Also Known As:

Networked: 482 relevant articles (26 outcomes, 56 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Trichinellosis
2.	Infection
3.	Cysticercosis
4.	Parasitic Diseases (Parasitic Disease)
5.	Echinococcosis (Hydatid Cysts)

Experts

1.	Cui, Jing: 10 articles (12/2015 - 02/2009)
2.	Wandurska-Nowak, Elzbieta: 9 articles (12/2012 - 01/2002)
3.	Wang, Zhong Quan: 6 articles (12/2015 - 01/2013)
4.	Jiang, Peng: 6 articles (12/2015 - 08/2012)
5.	Wang, Li: 6 articles (12/2015 - 01/2013)
6.	Bruschi, F: 6 articles (10/2011 - 06/2001)
7.	Liu, Ruo Dan: 5 articles (12/2015 - 01/2014)
8.	Derda, Monika: 5 articles (12/2012 - 01/2002)
9.	Dekumyoy, Paron: 5 articles (09/2012 - 03/2004)
10.	Boczoń, Krystyna: 5 articles (02/2007 - 01/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Trichinellosis:

1.	AntigensIBA 11/01/2011 - "However, crude antigen demonstrated a good specificity at 91.8%, and this antigen has a potential to be used as a detection of choice for swine trichinellosis, but the antigen preparation must be improved for higher specificity." 11/01/1983 - "The column antigen is therefore a major improvement in the EIA for swine trichinellosis." 02/01/1989 - "Comparative efficacy of antigen and antibody detection tests for human trichinellosis." 05/01/1986 - "Field evaluation of the enzyme-linked immunosorbent assay for swine trichinosis: efficacy of the excretory-secretory antigen." 09/01/1947 - "Improved antigen for the slide test for trichinosis."
2.	AntibodiesIBA 06/01/2013 - "In conclusion, there was a high prevalence of antibodies to trichinellosis in backyard raised pigs in Zaria, and intensive pig farming with the adoption of proper biosecurity measures is advocated to prevent the transmission and spread of trichinellosis." 07/01/2012 - "The detection of specific antibodies in the population to the pathogen of trichinosis is of great importance for the objective assessment of the epidemic situation in the foci of invasion and the prediction of sporadically occurring epidemics of this anthropozoonosis." 01/01/2009 - "Anti-Trichinella antibodies were detected in 8.0% (n=12) of the serum samples by more than one of the methodologies employed, considering these results as confirmatory of trichinellosis. " 07/01/2007 - "[Antibodies in trichinosis and duration of their detection in convalescents]." 05/01/2007 - "Furthermore, the detection of antibodies in stool samples, in either the free or complexed form, could be applied to confirm early human trichinellosis."
3.	Albendazole (Albenza)FDA Link 06/01/2003 - "To determine the efficacy of albendazole against the early stage (enteral phase) of trichinosis, mice experimentally infected with T. " 12/01/2012 - "The aim of this study was to evaluate the effect of albendazole--drug of choice for trichinellosis--on the total activity and kinetics of cytosolic GST in the mouse intestines during experimental trichinellosis. " 04/01/2015 - "[MORPHOLOGICAL CHANGES IN THE STRIATED MUSCLES AFTER ALBENDAZOLE TREATMENT FOR EXPERIMENTAL TRICHINOSIS]." 01/01/2014 - "Characterization of albendazole-randomly methylated-β-cyclodextrin inclusion complex and in vivo evaluation of its antihelmitic activity in a murine model of Trichinellosis." 07/01/2009 - "The effect of intestinal trichinellosis on oral bioavailability of albendazole in mice."
4.	Mebendazole (Vermin)FDA Link 04/01/1982 - "Mebendazole was highly effective against the helminth parasite Trichinella spiralis in mice subjected to a 3-day course of treatment during the enteral phase of experimental trichinellosis. " 01/01/1981 - "An improvement of the clinical picture and results of a biopsy examination supported our assumption that an effective treatment of acute trichinellosis requires high doses of mebendazole." 05/01/2007 - "Trichinellosis treated with Mebendazole often leads to complications in the course of the disease in humans and animals as a result of intoxication and hyper-sensitization of an organism due to the massive destruction of parasites. " 11/01/1996 - "It was concluded that severe trichinosis forms were frequently followed by myocardial damage, that severe forms responded faster and better serologically to trichinella and those patients should be treated with high mebendazole doses." 11/01/1984 - "[Vermox treatment of acute trichinelliasis recorded for the first time in Tomsk Province]."
5.	Immunoglobulin G (IgG)IBA 04/01/2010 - "The results indicate that the indirect ELISA using MLESA to detect IgG antibody in saliva may be helpful for clinical diagnosis of trichinellosis." 11/01/2014 - "The objective of this study was to assess the presence of anti-Trichinella IgG in the serum of persons from ethnic minorities from northwest Vietnam with clinical signs and symptoms that are compatible with trichinellosis. " 11/01/2014 - "Anti-Trichinella IgG in ethnic minorities living in Trichinella-endemic areas in northwest Vietnam: study of the predictive value of selected clinical signs and symptoms for the diagnosis of trichinellosis." 02/26/2010 - "The objective of the present study was to estimate the seroprevalence of anti-Trichinella IgG in free-roaming pigs (Sus scrofa) in the Son La province of northwestern Vietnam, where a human outbreak of trichinellosis occurred in June 2008. " 01/01/2004 - "Imported human trichinellosis: sequential IgG4 antibody response to Trichinella spiralis."
6.	Thiabendazole (Mintezol)FDA Link 11/01/1969 - "This study has failed to show any definite effect of thiabendazole on the course of human trichinosis at the doses used. " 04/01/1993 - "It can be concluded that treatment with Mintezol and 5-fluorouracil-Endoxan in trichinellosis represents a certain danger. " 07/01/1977 - "[Clinical and anatomopathological investigation in the treatment of acute trichinosis with thiabendazole (author's transl)]." 11/01/1969 - "Therapy in trichinosis with observations on the use of thiabendazole." 11/01/1969 - "Thiabendazole for the treatment of trichinosis in humans."
7.	flubendazoleIBA 06/01/2001 - "A trial was undertaken to assess the efficacy of flubendazole against experimentally induced trichinellosis in pigs when given mixed with food at different dose rates. " 01/01/1988 - "Randomized trial of albendazole versus tiabendazole plus flubendazole during an outbreak of human trichinellosis." 04/01/1987 - "We suggest that neurologic complications of trichinosis should be treated by corticosteroids and flubendazole." 01/01/1988 - "To determine the therapeutic usefulness of benzimidazoles in trichinellosis, 117 patients from a single outbreak were treated either with albendazole alone (N = 59) or with a regimen including tiabendazole followed by flubendazole (N = 58). "
8.	AnthelminticsIBA 06/15/2015 - "Among n = 37 persons who received anthelmintics as PEP, 6 persons developed trichinellosis. " 12/14/1979 - "Infections with nematode larvae as with Larva migrans and trichinoses are more problematic therapeutically because the anthelmintics are directed principally against the adult worms." 01/01/2012 - "Though anthelmintics such as mebendazole and albendazole are commonly used to treat human trichinellosis, none of these drugs are fully effective against the encysted or new-born larvae of Trichinella spiralis. " 01/01/2007 - "Since the idea of multifunctional mode of action of anthelmintics is considered and in experimental trichinellosis in vivo albendazole seems to act as an allosteric activator of cytosolic GST from mice muscles, in this study a termosensitivity after in vitro incubation with albendazole of purified commercial cytosolic glutathione transferase (GST) from the rat liver was investigated. "
9.	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/01/1969 - "[Behavior of N-acetylneuraminic acid in the serum of patients with trichinosis and in persons with cured trichinosis]." 01/01/2015 - "The levels of free and protein-bound sialic acid were increased and the total sialyltransferase activity was also elevated in the skeletal muscle tissue of animals with trichinellosis. " 09/01/1983 - "Sialic acid deficiency in lectin-resistant intestinal brush border membranes from rats following the intestinal phase of trichinellosis."
10.	GlucocorticoidsIBA 01/01/2001 - "Severe Trichinellosis cured with pulse doses of glucocorticoids." 09/01/1981 - "[Effect of benzimidazoles and glucocorticoids on the intestinal stage of experimental trichinosis in mice]." 10/01/1994 - "The hypersensitizing effect of benzimidazole carbamates (BC), the therapy for trichinellosis, especially in heavily infected patients, determines the necessity of simultaneous administration of glucocorticoids (GC) for the prevention of severe systemic and organ-specific complications. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 08/01/2012 - "spiralis and should be valuable to the early diagnosis and evaluation of the efficacy of chemotherapy in trichinellosis." 01/01/1986 - "Value of unspecific drugs in chemotherapy of trichinellosis." 02/11/1983 - "[Pharmacotherapy of trichinosis]." 12/01/1967 - "Comparative studies on the chemotherapy of experimental trichinosis in mice." 05/20/2013 - "Albendazole and mebendazole are widely used in the treatment of trichinellosis; however, chemotherapy failure has been reported. "
2.	Chemoprevention 06/01/2001 - "Complex chemoprophylaxis and treatment chemoprophylaxis gave some positive results to control trichinellosis in pig."
3.	Thymectomy 06/01/1970 - "Procedures known to deplete or inactivate the pool of recirculating lymphocytes such as neonatal thymectomy, administration of antilymphocyte serum, and prolonged thoracic duct drainage, either singly or in combination, resulted in a highly significant reduction in the eosinophil response to trichinosis. "
4.	Microspheres (Microsphere) 02/01/1962 - "A slide latex-particle agglutination test for trichinosis." 01/01/1962 - "A slide latex-particle agglutination test for trichinosis." 12/01/1982 - "Black bears (Ursus americanus) from 3 geographic areas of California were tested for antibodies against agents of 6 zoonotic diseases: toxoplasmosis (indirect hemagglutination), Q fever (microagglutination), trichinosis (latex particle agglutination), botulism (passive hemagglutination), leptospirosis (plate agglutination), and plague (enzyme-linked immunosorbent assay). "
5.	Immunomodulation 03/01/2012 - "The principal evasion mechanisms of host immune response occurring in trichinellosis are described, some of which are shared by other parasites, some others are peculiar of this parasite, but particular attention is focused on immunomodulation and the possibilities to exploit this parasite ability to verify the effects on immuno-mediated diseases. " 03/01/2012 - "Immunomodulation in trichinellosis: does Trichinella really escape the host immune system?" 04/01/1984 - "Immunomodulation by Propionibacterium granulosum KP 45 and experimental trichinellosis in mice."