Triazolam (Halcion)

A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.

Also Known As:

Networked: 258 relevant articles (21 outcomes, 40 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Griffiths, Roland R: 3 articles (02/2010 - 09/2005)
2.	Richards, Bethan L: 2 articles (09/2012 - 01/2012)
3.	Buchbinder, Rachelle: 2 articles (09/2012 - 01/2012)
4.	Whittle, Samuel L: 2 articles (09/2012 - 01/2012)
5.	Bista, Sabin R: 2 articles (01/2012 - 08/2010)
6.	Chowdhuri, Susmita: 2 articles (01/2012 - 08/2010)
7.	Casey, Kenneth R: 2 articles (01/2012 - 08/2010)
8.	Kristo, David A: 2 articles (01/2012 - 08/2010)
9.	Zak, Rochelle S: 2 articles (01/2012 - 08/2010)
10.	Lamm, Carin I: 2 articles (01/2012 - 08/2010)

Related Diseases

1.	Sleep Initiation and Maintenance Disorders (Insomnia) 05/01/1983 - "Overall, triazolam is an effective and safe compound for the symptomatic treatment of insomnia complaints." 08/01/1981 - "Triazolam: a review of its pharmacological properties and therapeutic efficacy in patients with insomnia." 08/01/1993 - "The authors examined sleep improvement in subjects with primary insomnia who received triazolam plus behavioral therapy (N = 8) or triazolam plus sleep-related information (N = 7). " 11/01/1983 - "A double-blind crossover study in 53 psychiatric outpatients compared the safety and efficacy of triazolam and placebo in relieving insomnia refractory to treatment with a tricyclic antidepressant. " 01/01/2002 - "Sixty-four healthy men and women with and without insomnia (aged 21-55 years) were given an opportunity to self-administer placebo or triazolam (0.25 mg) capsules (single-choice method - available capsule or no capsule) before sleep in three separate studies. "
2.	Pain (Aches) 04/01/2006 - "Our data indicate that oral triazolam is beneficial in decreasing pain and anxiety associated with self-activated atrial defibrillation. " 01/01/1998 - "Triazolam improves sleep but fails to alter pain in TMD patients." 08/01/1997 - "Sublingual triazolam resulted in significantly less anxiety and pain at 15 minutes intraoperatively than both oral triazolam and placebo (p < 0.05). " 04/01/2006 - "Decreasing pain and anxiety associated with patient-activated atrial shock: a placebo-controlled study of adjunctive sedation with oral triazolam." 04/01/2006 - "Triazolam reduced mean pre-shock anxiety (t= 2.98, df = 14, P = 0.01) and shock-related pain (t= 2.74, df = 13, P = 0.01) and intensity (t= 2.64, df = 13, P = 0.018) relative to placebo. "
3.	Substance-Related Disorders (Drug Abuse) 01/01/2001 - "In the third, rats were treated chronically three daily doses of triazolam (started by 0.25 mg/kg and increased by time to 0.5 mg/kg) for 20 days, simulating a form of drug abuse. " 01/01/2000 - "In the third, rats were treated chronically with three daily doses of Triazolam (started with 0.25 mg/kg and increased by time to 0.5 mg/kg) for 20 days, representing a form of drug abuse. " 02/01/1995 - "The two subjects who did not self-administer triazolam in preference to placebo also had lesser histories of drug dependence. " 07/01/1999 - "The present study compared the acute subject-rated effects, performance-impairing effects, and abuse potential of zaleplon and triazolam, a triazolobenzodiazepine hypnotic, in 14 healthy volunteers with histories of drug abuse. " 01/01/2000 - "In conclusion, chronic single daily dose treatment (representing normal use) produces tolerance to Triazolam effects on brain GABA levels, while chronic three daily doses administration (akin to drug abuse) causes a fall in GABA levels."
4.	Shock 04/01/2006 - "The main objective of the present study was to determine whether triazolam improved patient perception of the shock experience or altered patient memory of shock discomfort relative to placebo. " 04/01/2006 - "Similarly, participants recalled less discomfort the morning after shock with triazolam than with placebo (t= 2.82, df = 11, P = 0.017). " 07/01/2004 - "In contrast, triazolam only decreased errors and enhanced acquisition in the presence of concurrent response-independent tail shock when compared to saline administration under this condition. " 02/01/1999 - "Six monkeys discriminated 0.1 mg/kg of triazolam from vehicle under a fixed-ratio 5 (FR 5) schedule of stimulus-shock termination (SST). " 01/01/1995 - "Triazolam (0.01-0.1 mg/kg, s.c.), administered before training, attenuated the suppression of motility in the conditioned fear stress task in a dose-dependent manner, without affecting the sensitivity to an electric foot shock. "
5.	Chronic Obstructive Pulmonary Disease (COPD) 10/01/1988 - "We conclude that single-night use of triazolam improved the quality and duration of sleep in patients with chronic obstructive pulmonary disease. " 06/01/1993 - "Effects of zolpidem and triazolam on sleep and respiration in mild to moderate chronic obstructive pulmonary disease." 10/01/1988 - "Effect of triazolam on sleep and arterial oxygen saturation in patients with chronic obstructive pulmonary disease." 10/01/1988 - "We compared the effects of a placebo with 0.125 and 0.25 mg of triazolam (Halcion) on sleep quality, oximetry, and respiratory events during sleep in ten stable outpatients with chronic obstructive pulmonary disease. " 03/01/1990 - "Comparison of zolpidem (Z), triazolam (T), and flunitrazepam (F) effects on arterial blood gases and control of breathing in patients with severe chronic obstructive pulmonary disease (COPD)."

Related Drugs and Biologics

1.	Benzodiazepines
2.	Flurazepam (Dalmane)
3.	Temazepam (Nocturne)
4.	zopiclone (Zop)
5.	Diazepam (Valium)
6.	zolpidem (Ambien)
7.	Flunitrazepam (Rohypnol)
8.	Trazodone (Trittico)
9.	zaleplon (Sonata)
10.	Nitrazepam (Serenade)

Related Therapies and Procedures

1.	Operating Tables
2.	Preoperative Period
3.	Conscious Sedation
4.	Premedication
5.	Hypnosis (Mesmerism)