Trehalose

07/01/2003 - "During the dehydration process, larvae accumulate large amounts of trehalose, which provides effective protection against desiccation because of its high capacity for water replacement and vitrification. "
07/01/1998 - "The disaccharide trehalose is found to be effective for stabilization of active recombinant retroviruses in an amorphous dry state achieved through ambient-temperature vacuum dehydration of retroviral supernatants. "
01/01/2003 - "As dehydration-induced damage is in correlation with osmotic response recovery and is hindered or buffered by the presence of trehalose, it may be related to water eliminated from biological structures involved in water permeation."
12/14/2009 - "The study also underlines that the characterization of the average phase by conventional XRPD and DSC techniques is not sufficient to describe the dehydration mechanisms of alpha,alpha-trehalose particles. "
04/01/2009 - "In this study, we examined how rates and levels of dehydration alter heat and cold tolerance and how these relate to levels of trehalose within the insect. "

06/01/2014 - "Deciphering the roles of trehalose and Hsp104 in the inhibition of aggregation of mutant huntingtin in a yeast model of Huntington's disease."
01/01/2014 - "These results suggest that trehalose could revert protein processing abnormalities in patients with Huntington's Disease. "
01/01/2014 - "Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition."
01/01/2009 - "The present investigation examined the neuroprotective benefits for combined trehalose administration with C17.2 neural stem cell transplantation in a transgenic mouse model of Huntington's disease (HD), R6/2. C17.2 neural stem cells have the potential of differentiating into a neuronal phenotype in vitro and have been shown to be effective in the treatment of a variety of lysosomal lipid storage disorders in the nervous system. "
01/01/2009 - "Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease."

01/01/1999 - "cerevisiae exposed to sorbate at low pH. In pH 3.5 cultures, a 25 degrees C sorbate treatment is as effective as a 39 degrees C heat shock in inducing trehalose. "
01/01/2008 - "After pre-treatment at 40 degrees C for 60 min, and heat shock at 52 degrees C for 8 min, eight strains maintained their trehalose levels and nine strains improved their resistance against lethal heat shock. "
04/01/2015 - "The lack of trehalose in the ΔotsA mutant resulted in oxidative stress, manifested by increased membrane lipid peroxidation after heat shock. "
01/01/2014 - "They synthesize trehalose at a metabolic cost, which helps protect against heat shock. "
07/01/2010 - "However, deletion of both tpsA and tpsB was required to block trehalose accumulation during development and heat shock. "

01/01/1986 - "Complete protection against lethal influenza virus infection was conferred when MPL was combined with trehalose dimycolate (TDM). "
09/01/2010 - "Finally, vaccination of mice using microneedles stabilized by trehalose generated strong antibody responses and provided full protection against high-dose lethal challenge infection. "
03/01/1992 - "In gamma- and neutron-irradiated mice, the immunomodulator trehalose dimycolate (TDM) was effective in treating endogenous infection. "
10/01/2006 - "Recent studies in the pathobiology of Cryptococcus neoformans identified the presence of a functioning trehalose pathway during infection and suggested its importance for C. "
08/01/1989 - "In this study we determined if the cell wall glycolipid trehalose dimycolate (TDM), derived from Mycobacterium phlei, or a synthetic preparation of TDM was able to (i) enhance survival in mice when given before or after lethal doses of 60Co radiation and (ii) increase nonspecific resistance to postirradiation infection. "

11/01/2002 - "Trehalose solution was an effective and safe eyedrop for the treatment of moderate to severe dry eye syndrome in this group of patients."
05/01/2001 - "This study was designed to examine whether trehalose could protect corneal epithelial cells in culture from death by desiccation in order to test trehalose as a potential new eye drop for dry eye syndrome. "
01/01/2011 - "These unique properties of trehalose have thus prompted its investigation as a component in treatment for dry eye syndrome. "
05/01/2001 - "Trehalose could be used as a potential new eye drop for dry eye syndrome."
07/01/2004 - "Trehalose eyedrops were found by a previous study to be safe and effective compared with saline in the treatment of moderate-to-severe dry eye syndrome. "