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Trazodone (Trittico)

A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)

Also Known As:

Trittico; Desyrel; Thombran; Deprax; Molipaxin; AF-1161; Apo-Trazodone; Apotex Brand of Trazodone Hydrochloride; Apothecon Brand of Trazodone Hydrochloride; Aventis Brand of Trazodone Hydrochloride; Aventis Pharma Brand of Trazodone Hydrochloride; Boehringer Ingelheim Brand of Trazodone Hydrochloride; Bristol-Myers Squibb Brand of Trazodone Hydrochloride; Farma Lepori Brand of Trazodone Hydrochloride; Gen-Trazodone; Genpharm Brand of Trazodone Hydrochloride; Hexal Brand of Trazodone Hydrochloride; Novo-Trazodone; Novopharm Brand of Trazodone Hydrochloride; Nu-Pharm Brand of Trazodone Hydrochloride; Nu-Trazodone; PMS-Trazodone; Pharmascience Brand of Trazodone Hydrochloride; Ratiopharm Brand of Trazodone Hydrochloride; Searle Brand of Trazodone Hydrochloride; Sidmark Brand of Trazodone Hydrochloride; Tradozone; Trazodon Hexal; Trazodon-neuraxpharm; Trazodone Hydrochloride; Trazon; neuraxpharm Brand of Trazodone Hydrochloride; ratio-Trazodone; AF 1161; AF1161; Apo Trazodone; Bristol Myers Squibb Brand of Trazodone Hydrochloride; Gen Trazodone; Novo Trazodone; Nu Pharm Brand of Trazodone Hydrochloride; Nu Trazodone; PMS Trazodone; Trazodon neuraxpharm; ratio Trazodone; 1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-

Networked: 529 relevant articles (70 outcomes, 89 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Pyridines: 41
    - Pyridones: 10
      - Trazodone: 529
        etoperidone: 2
        5,6,7,8-tetrahydrotrazodone
        5-(1-hydroxyethyl)etoperidone
        5-(1-oxoethyl)etoperidone
        trazolan
  - Piperazines: 18
    - Trazodone: 529

Experts

1.	Florkowski, Antoni: 4 articles (12/2011 - 05/2005)
2.	Gałecki, Piotr: 4 articles (12/2011 - 05/2005)
3.	Naves, Janeth O S: 3 articles (11/2015 - 12/2014)
4.	McIntyre, Roger S: 3 articles (10/2015 - 11/2014)
5.	Camargos, Einstein Francisco: 3 articles (09/2015 - 02/2011)
6.	Fagiolini, Andrea: 3 articles (01/2015 - 08/2012)
7.	Weizman, Abraham: 3 articles (10/2014 - 05/2003)
8.	Wierzbicka, Aleksandra: 3 articles (08/2011 - 07/2007)
9.	Wichniak, Adam: 3 articles (08/2011 - 07/2007)
10.	Becker, Philip M: 3 articles (09/2009 - 11/2005)

Related Diseases

1.	Sleep Initiation and Maintenance Disorders (Insomnia) 04/01/2005 - "Evidence for the efficacy of trazodone in treating insomnia is very limited; most studies are small, conducted in populations of depressed patients, raise issues of design, and often lack objective efficacy measures. " 01/01/2003 - "Evaluation of the target symptoms of trazodone by ranking the most improved symptoms identified insomnia as the most improved psychopathological item in all three scales. " 06/01/2010 - "Trazodone is an sedative antidepressant, acting quickly, efficiently, safely, with a small number of adverse reactions and proven effective in the treatment of insomnia." 01/01/2005 - "After trazodone introduction, insomnia improved and the median (interquartile range) of this item in G1 and G2 patients showed no statistically significant difference on Day 28 (G1: 0 (0-1); G2: 0 (0-2)). " 08/01/1983 - "In the subjective ratings, sleep improved in quality on trazodone, significantly so in the first and second weeks of intake, though with significant rebound insomnia on the second withdrawal night. "
2.	Pain (Aches) 01/01/1999 - "An 8-week parallel, placebo-controlled, double-blind trial evaluated the efficacy of the antidepressant trazodone in the treatment of chronic burning mouth pain. " 01/01/1999 - "In this controlled trial, trazodone failed to relieve burning mouth pain." 05/01/2003 - "The results suggest that a mainly serotonergic descending pain control pathway mediates the analgesic effects of trazodone." 09/01/2000 - "These results explain the diffuse clinical use of trazodone in the management of some pain syndromes, and in opioid- and alcohol-detoxification programs, but raise questions regarding a possible 'indirect' opioid-dependence induced by trazodone itself." 01/01/1999 - "Trazodone in burning mouth pain: a placebo-controlled, double-blind study."
3.	Erectile Dysfunction 08/01/2000 - "This study examined the efficacy of trazodone 200 mg/day in patients with erectile dysfunction (ED) without major organic findings. " 06/01/1999 - "A placebo controlled, fixed dose, double-blind crossover study was performed to evaluate the safety and efficacy of oral trazodone for the treatment of erectile dysfunction. " 09/01/1997 - "In a group of patients, that was not selected on the basis of the etiology of the erectile dysfunction, nor selected on the duration of the complaint, the efficacy of trazodone 150 mg/d, could not be shown." 08/01/2000 - "Trazodone: a double-blind, placebo-controlled, randomized study of its effects in patients with erectile dysfunction without major organic findings." 06/01/1999 - "Oral trazodone is not effective therapy for erectile dysfunction: a double-blind, placebo controlled trial."
4.	Dementia (Dementias) 01/01/2004 - "In order to assess effectiveness and safety of trazodone, longer-term trials are needed, involving larger samples of participants with a wider variety of types and severities of dementia." 01/01/2004 - "All unconfounded, double-blind, randomised controlled trials, comparing trazodone with placebo in managing behavioural and psychiatric symptoms (except depression) in any type of dementia. " 02/01/1993 - "In this equivalence study the effect of 5'-MTHF on depressive symptoms and cognitive status was compared to Trazodone (TRZ) in normofolatemic elderly patients with mild to moderate dementia and depression. " 09/01/2013 - "Due to its special anxiolytic and sleep normalising effect and well-tolerated side effect profile trazodone is found to be clinically useful not only in the treatment of depression in the elderly, but also in the case of serious comorbidity with dementia or agitated behaviour. " 02/01/2011 - "Trazodone has been shown to be a good option for treatment of the elderly with dementia and associated SD."
5.	Anxiety Disorders (Anxiety Disorder) 06/01/1987 - "There was significant improvement on all symptom dimensions, which suggests that trazodone may have specific antipanic and antiphobic actions and underscores the importance of serotonergic mechanisms in these anxiety disorders." 12/15/2008 - "To evaluate efficacy of trazodone hydrochloride as an adjunctive treatment for anxiety disorders as well as treatment protocol, dose range, concurrent drug use, adverse events, and therapeutic response in dogs unresponsive to other pharmacologic agents. " 12/15/2008 - "Medical records of dogs with anxiety disorders adjunctively treated with trazodone were retrospectively evaluated with respect to signalment, primary and secondary behavioral diagnoses, physical examination results, hematologic data (CBC and serum biochemical panel), pharmacologic management, and outcome. " 12/15/2008 - "Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases (1995-2007)." 08/01/2010 - "Trazodone was the most commonly prescribed insomnia medication for children with mood (78%) and anxiety disorders (72%). "

Related Drugs and Biologics

1.	Antidepressive Agents (Antidepressants)
2.	Serotonin (5 Hydroxytryptamine)
3.	Imipramine (Janimine)
4.	nefazodone (Serzone)
5.	Antipsychotic Agents (Antipsychotics)
6.	Haloperidol (Haldol)
7.	Mianserin
8.	Hypnotics and Sedatives (Sedatives)
9.	Bupropion (Wellbutrin)
10.	Benzodiazepines

Related Therapies and Procedures

1.	Injections
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Activities of Daily Living (ADL)
5.	Hypnosis (Mesmerism)