Transposition of Great Vessels (Great Vessels Transposition)

A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.

Also Known As:

Networked: 132 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Bronchitis
2.	Tetralogy of Fallot (Fallot Tetralogy)
3.	Hypoplastic Left Heart Syndrome
4.	Ventricular Heart Septal Defects (Ventricular Septal Defect)
5.	Double Outlet Right Ventricle

Experts

1.	Choudhary, Shiv Kumar: 3 articles (01/2012 - 11/2002)
2.	Kothari, Shyam Sunder: 3 articles (01/2012 - 11/2002)
3.	Czeizel, Andrew E: 2 articles (10/2015 - 10/2013)
4.	Vereczkey, Attila: 2 articles (10/2015 - 10/2013)
5.	Morgan, John: 2 articles (09/2015 - 02/2008)
6.	Sharma, Rajesh: 2 articles (04/2015 - 11/2002)
7.	Sípek, A: 2 articles (10/2012 - 12/2008)
8.	Langhammer, P: 2 articles (10/2012 - 12/2008)
9.	Gregor, V: 2 articles (10/2012 - 12/2008)
10.	Saxena, Anita: 2 articles (01/2012 - 11/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Transposition of Great Vessels:

1.	Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)FDA Link 01/01/2015 - "Spontaneous resolution of plastic bronchitis in a patient post hemi-Mustard/bidirectional Glenn atrial switch procedure in the double-switch operation for congenitally corrected transposition of great arteries after course of Augmentin."
2.	PlasticsIBA 01/01/2015 - "Spontaneous resolution of plastic bronchitis in a patient post hemi-Mustard/bidirectional Glenn atrial switch procedure in the double-switch operation for congenitally corrected transposition of great arteries after course of Augmentin."
3.	Hereditary renal agenesisIBA 12/01/2008 - "Mean incidences (per 10,000 live births) and prenatal diagnostics rate (%, in brackets) were as follows: anencephaly 2.81 (95.65), spina bifida 4.13 (61.12), encephalocele 0.99 (77.04), congenital hydrocefalus 4.32 (49.61), omfalocele 2.59 (54.97), gastroschisis 2.88 (77.30), diafragmatic hernia 2.40 (22.02), cystic kidney 5.16 (24.80), renal agenesis/hypoplasia 5.02 (25.97), transposition of great vessels 6.93 (7.85), tetralogy of Fallot 6.28 (5.87), hypoplastic left heart syndrome 4.63 (39.86) and coarctation of aorta 8.46 (3.80). " 01/01/2005 - "Included were all live births, fetal deaths and terminations of pregnancy diagnosed with one or more of the following malformations: anencephalus, encephalocele, spina bifida, hydrocephalus, transposition of great arteries, hypoplastic left heart, limb reduction defect, bilateral renal agenesis, diaphragmatic hernia, omphalocele and gastroschisis. " 12/01/2008 - "Following total numbers of particular birth defects were registered during the 1994-2007 period: anencephaly 380, spina bifida 559, encephalocele 1134, congenital hydrocefalus 584, omfalocele 351, gastroschisis 389, diafragmatic hernia 325, cystic kidney 698, renal agenesis/hypoplasia 679, transposition of great vessels 797, tetralogy of Fallot 723, hypoplastic left heart syndrome 533 and coarctation of aorta 973. " 12/01/2008 - "Total numbers and mean incidences of selected types of defects (anencephaly, spina bifida, encephalocele, congenital hydrocefalus, omfalocele, gastroschisis, diafragmatic hernia, cystic kidney, renal agenesis/hypoplasia, transposition of great vessels, tetralogy of Fallot, hypoplastic left heart syndrome and coarctation of aorta) during the period under the study were analyzed. "
4.	Neural tube defects X-linkedIBA 12/01/2008 - "Total numbers and mean incidences of selected types of defects (anencephaly, spina bifida, encephalocele, congenital hydrocefalus, omfalocele, gastroschisis, diafragmatic hernia, cystic kidney, renal agenesis/hypoplasia, transposition of great vessels, tetralogy of Fallot, hypoplastic left heart syndrome and coarctation of aorta) during the period under the study were analyzed. " 10/01/2012 - "Sixteen selected defects (anencephaly, spina bifida, encephalocele, congenital hydrocephalus, coarctation of aorta, transposition of great vessels, hypoplastic left heart syndrome, Fallot tetralogy, omphalocele, gastroschisis, diaphragmatic hernia, oesophageal atresia and stenosis, anorectal malformations, Down syndrome, Edwards syndrome and Patau syndrome) were analyzed in detail. "
5.	1,2-didecanoyl-3-phosphatidic acid (PA(10))IBA 01/01/2013 - "The current study aimed to develop a reliable targeted array comparative genomic hybridization (aCGH) to detect microdeletions and microduplications in congenital conotruncal defects (CTDs), especially on 22q11.2 region, and for some other chromosomal aberrations, such as 5p15-5p, 7q11.23 and 4p16.3. Twenty-seven patients with CTDs, including 12 pulmonary atresia (PA), 10 double-outlet right ventricle (DORV), 3 transposition of great arteries (TGA), 1 tetralogy of Fallot (TOF) and one ventricular septal defect (VSD), were enrolled in this study and screened for pathogenic copy number variations (CNVs), using Agilent 8 x 15K targeted aCGH. "
6.	beta-cyclodextrin tetradecasulfate (CTDS)IBA 01/01/2013 - "The current study aimed to develop a reliable targeted array comparative genomic hybridization (aCGH) to detect microdeletions and microduplications in congenital conotruncal defects (CTDs), especially on 22q11.2 region, and for some other chromosomal aberrations, such as 5p15-5p, 7q11.23 and 4p16.3. Twenty-seven patients with CTDs, including 12 pulmonary atresia (PA), 10 double-outlet right ventricle (DORV), 3 transposition of great arteries (TGA), 1 tetralogy of Fallot (TOF) and one ventricular septal defect (VSD), were enrolled in this study and screened for pathogenic copy number variations (CNVs), using Agilent 8 x 15K targeted aCGH. "
7.	Pulmonary venous return anomalyIBA 01/01/1994 - "Surgical repair of transposition of great arteries and total anomalous pulmonary venous return to the coronary sinus (TGA with TAPVR)." 10/01/2009 - "Total anomalous pulmonary venous return, transposition of great arteries an hypoplastic left heart syndrome diagnoses accounted for 75% of the procedures. " 11/01/2006 - "The cardiac pathology was transposition of great arteries in 133 cases, tetralogy of Fallot in 37, aorticopulmonary window associated with interrupted aortic arch in 4 and total anomalous pulmonary venous return in 5, and other complex pathology in 7 cases. " 02/01/2013 - "Two patients with congenital heart disease were also included to detect possible patterns of flow abnormalities (Patient 1: corrected transposition of great arteries (TGA); Patient 2: partial anomalous pulmonary venous return and atrial septal defect). " 11/01/2004 - "Significantly higher rates were found among males for transposition of great arteries, aortic valve stenosis, and interrupted aortic arch and, among females, for ventricular septal defect, endocardial cushion defect, and anomalous pulmonary venous return. "
8.	Coarctation of the aortaIBA 01/01/2005 - "[Two-stage repair of the transposition of great arteries with interruption/coarctation of the aorta]." 10/01/1998 - "Transposition of great arteries and coarctation of the aorta are rarely seen. " 10/01/2007 - "SSS occurred after three main types of surgery: repair of coarctation of the aorta, repair of AVSD and LV-aorta rerouting for double outlet right ventricle or transposition of great arteries. " 02/01/2013 - "Are the risks of hypoplastic left heart syndrome, transposition of great arteries, tetralogy of Fallot (TOF) and coarctation of the aorta increased in infants conceived by different assisted reproductive techniques (ARTs)? " 10/15/2010 - "Relational and sexuality issues were assessed using a sexuality questionnaire in 133 patients (52% men, 37 ± 13 years old) with CHD (43 with coarctation of the aorta, 42 with transposition of great arteries, 36 with Marfan syndrome, and 12 with Eisenmenger syndrome), and 74 partners. "
9.	Complete atrioventricular septal defectIBA 01/01/1998 - "Two-stage correction of transposition of great arteries with complete atrioventricular canal." 06/01/1992 - "[Biventricular repair for right isomerism associated with transposition of great arteries and common atrioventricular canal]." 12/01/2001 - "The numbers describe in the following order patient years (y), number of patients (n), and freedom from reoperation at follow-up interval (%), respectively: atrial septal defect (15,864y, n=1198, 99+/-0/99+/-0/99+/-0), partial atrioventricular septal defect (2506y, n=234, 95+/-2/93+/-2/93+/-2), total anomalous pulmonary venous connection (742y, n=141, 93+/-1/91+/-0/91+/-0), complete atrioventricular septal defect (1715y, n=377, 81+/-3/76+/-3/72+/-4), tetralogy of Fallot <1 year (1503y, n=197, 94+/-4/85+/-1/74+/-3), transposition of great arteries (1459y, n=375, 88+/-2/83+/-4/73+/-7), interrupted aortic arch (IAA) (481y, n=98, 63+/-6/52+/-7/45+/-8), common arterial trunk (CAT) (599y, n=109, 64+/-6/24+/-6/11+/-5). " 06/01/1992 - "A 5-years old boy, whose thoracic situs was right isomerism, was diagnosed as transposition of great arteries, common atrioventricular canal (intermediate type), severe tricuspid valve regurgitation, pulmonary valve stenosis, bilateral superior vena cava and left sided inferior vena cava. " 01/10/2003 - "The experience of surgical treatment of 8 newborns with critical congenital heart diseases, including 3 cases of D-transposition of great arteries with intact ventricular septum, 2 cases of ventricular septal defect with artrial defect (ASD), one case of complete atrioventricular canal defect, 1 case of obstructed supracardiac total anomalous pulmonary venous drainage with ASD, and 1 case of patent ductus arteriosus (PDA). "
10.	Conotruncal cardiac defectsIBA 01/01/2014 - "Conotruncal cardiac defects except transposition of great arteries were strongly associated with 22q11.2 deletion. " 05/01/2012 - "We studied 31 normal fetuses and 28 fetuses with congenital heart disease (6 with double-outlet right ventricle, 5 with complete transposition of great arteries, 8 with tetralogy of Fallot, 3 with right aortic arch, 2 with persistent left superior vena cava, 3 with truncus arteriosus communis, and 1 with interruption of aortic arch) at gestation ages ranging from 18 to 39 weeks using transabdominal 4D B-flow sonography with STIC (4D BF-STIC). " 10/01/2008 - "We prospectively enrolled 214 children with conotruncal defects: 126 with tetralogy of Fallot (TOF), 18 with pulmonary atresia-ventricular septal defect (PA-VSD), 15 with truncus arteriosus communis (TAC) type I, one with interrupted aortic arch (IAA) type B, and 54 with the transposition of great arteries, who were consecutively hospitalized at the Pediatric Cardiology Department between 2003 and 2005. " 04/01/1997 - "The CCVDs comprised complex conotruncal defects such as tetralogy of Fallot, double outlet right ventricle, transposition of great arteries and truncus arteriosus communis, or anomalies of the derivatives of the branchial arch arteries in association with a ventricular septal defect, including one case of atresia of the ductus arteriosus with pulmonary artery aneurysm and resulting in fetal hydrops. " 01/01/2000 - "Cardiac diagnoses included patent ductus arteriosus (PDA) (N = 21, 28.7%), ventricular septal defect (VSD) (N = 9, 12.3%), transposition of great arteries (TGA) (N = 10, 13.7%), tetralogy of Fallot (TOF) (N = 7, 9.6%), double-outlet right ventricle (DORV) (N = 4, 5.5%), truncus arteriosus communis (TAC) (N = 4, 5.5%), hypoplastic left heart syndrome (HLHS) (N = 4, 5.5%), coarctation of aorta (CoAo) (N = 6, 8.2%), total anomalous pulmonary venous return (TAPVR) (N = 2, 2.7%), aortic stenosis (AoVS) (N = 3, 4.1%), interrupted aortic arch (IAA) (N = 1, 1.4%), pulmonary atresia (PA) (N = 1, 1.4%) and common atrioventricular canal (CAVC) (N = 1, 1.4%). "

Therapies and Procedures

1.	Fontan Procedure (Fontan Operation) 08/01/2009 - "The Fontan procedure is performed for patients with a corrected transposition of great arteries, and pregnancies following this surgery are likely to increase in number. " 12/01/2002 - "Trans-aortic His bundle ablation with permanent ventricular pacing via the coronary sinus in L-transposition of great arteries with classic Fontan procedure." 12/01/1986 - "[Modified Fontan operation after pulmonary artery banding for a single ventricle with levo-transposition of great arteries: a case report]." 04/01/2011 - "Most advice given to patients with intermediate risk lesions (i.e., Fontan operation, transposition of great arteries, cyanotic heart disease without pulmonary hypertension) are based on theoretical determination of risk, and there are few studies done to validate these recommendations. " 08/01/1997 - "[A case of modified Fontan operation for corrected transposition of great arteries (I.D.D.) with atrial septal defect, ventricular septal defect, pulmonary stenosis, mitral atresia and hypoplastic left ventricle]."
2.	Patient Readmission 10/01/2015 - "Objective The aim of the study is to determine the number and indications of unplanned hospital readmissions and emergency room visits for children with hypoplastic left heart syndrome (HLHS) or transposition of great arteries (TGA). "
3.	Transplants (Transplant) 09/01/2015 - "There is limited clinical experience with bridging to transplant with a left ventricular assist device (VAD) in patients with previously palliated transposition of great arteries. " 01/01/2012 - "As, aorta is located anterior to and left of the PA (Transposition of great arteries), the outflow graft of ventricular assist device traverse across pulmonary artery to reach aorta which poses challenge during further surgical explorations." 01/01/2012 - "Ventricular assist device outflow graft in congenitally corrected transposition of great arteries - a surgical challenge." 08/01/1997 - "We report successful use of the left internal mammary artery graft for a neonate with coronary hypoperfusion after the arterial switch operation for transposition of great arteries with intramural left coronary artery. " 12/01/1972 - "[Surgery of transposition of great vessels by Rastelli's method using a prosthetic graft and a heterologous pulmonary valve]."
4.	Heart Transplantation (Grafting, Heart) 01/18/2015 - "A very close follow-up is necessary to establish the correct period for heart transplantation in patients with transposition of great arteries with Senning/Mustard operation, and univentricular heart corrected with "Fontan-circulation" type surgical procedure. " 12/01/2008 - "Orthotopic heart transplantation in a patient with corrected L-transposition of great arteries and dextrocardia." 12/01/2004 - "Lesions including transposition of great arteries, tetralogy of Fallot, hypoplastic left heart syndrome, total anomalous pulmonary venous connection, and single ventricle lesions requiring Fontan palliation or cardiac transplantation are discussed." 11/01/2010 - "Congenital heart disease (CHD) was present in 37% (24/65) of patients (7 tetralogy of Fallot, 6 Ebstein's, 4 double-outlet right ventricle, 3 complex CHD, 2 d-transposition of great arteries, 1 status-post orthotopic heart transplantation, 1 ventricular septal defect). "
5.	Palliative Care (Palliative Medicine) 12/01/1974 - "[Results of palliative treatment of children with transposition of great vessels]." 07/01/1971 - "Palliative treatment of transposition of great arteries." 07/01/1969 - "[Palliative surgery in transposition of great vessels]." 12/10/1970 - "[Transatrial septostomy with balloon catheters for palliative therapy of complete transposition of great vessels]."