Transketolase

An enzyme of the transferase class that catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate in the PENTOSE PHOSPHATE PATHWAY. (Dorland, 27th ed) EC 2.2.1.1.

Also Known As:

Networked: 384 relevant articles (6 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Coy, Johannes F: 12 articles (04/2017 - 01/2005)
2.	Cascante, Marta: 7 articles (03/2022 - 02/2006)
3.	Tong, Xuemei: 6 articles (01/2022 - 01/2019)
4.	Lu, Ying: 5 articles (01/2022 - 01/2019)
5.	Tong, Lingfeng: 5 articles (01/2022 - 01/2019)
6.	Xu, Tianle: 5 articles (01/2022 - 01/2019)
7.	Zhang, Song: 5 articles (03/2009 - 04/2007)
8.	Li, Minle: 4 articles (01/2022 - 01/2019)
9.	Li, Yakui: 4 articles (01/2022 - 01/2019)
10.	Tian, Na: 4 articles (01/2022 - 01/2019)

Related Diseases

1.	Thiamine Deficiency 08/23/1979 - "Thus, thiamine deficiency, established as a significant reduction of red blood cell transketolase activity, seems to have a deleterious effect on the peripheral nerves and muscles. " 02/01/2015 - "Erythrocyte transketolase testing has shown that thiamine deficiency is widespread. " 01/01/2014 - "Downregulation of transketolase activity is related to inhibition of hippocampal progenitor cell proliferation induced by thiamine deficiency." 01/01/2011 - "Blood samples taken from 16 cases prior to treatment showed increased levels of erythrocyte transketolase activation coefficient, consistent with thiamine deficiency. " 10/01/2009 - "Decreased transketolase activity contributes to impaired hippocampal neurogenesis induced by thiamine deficiency."
2.	Neoplasms (Cancer) 01/01/2018 - "In this study, the transketolase (TKT) expression correlated with tumor size in the 4T1/BALB/c syngeneic model. " 01/01/2011 - "Based on studies performed with a selected mouse monoclonal anti-transketolase- like (TKTL)-1 antibody (clone JFC12T10), overexpression of TKTL-1 has been shown to be correlated with poor survival and increased metastatic spread in several human tumor entities. " 02/05/2010 - "In this study, we investigated the effect of inhibition of the transketolase pathway on signaling pathways in MIA PaCa cancer cells using in-house proteomic techniques. " 05/17/2023 - "We employed exogenous fluorescence reporter gene mCherry and endogenous gene transketolase (TKT) closely related to cancer cell metabolism as target genes to evaluate the Cas13X.1 system. " 08/09/2016 - "A key role for transketolase-like 1 in tumor metabolic reprogramming."
3.	Ataxia (Dyssynergia) 10/01/1985 - "Feeding of a thiamine-deficient diet to adult rats resulted in 5-7 weeks in ataxia and loss of righting reflex accompanied by decreased blood transketolase activities. " 08/01/1987 - "There were no laboratory or physiological markers for ataxia, including hemoglobin A1a + b, red blood cell transketolase, liver function enzymes, and measures of reaction time and hand-eye coordination. " 03/01/2010 - "This includes evidence of abnormal pyruvate metabolism reversed by thiamine in patients with TAN, evidence from erythrocyte transketolase activity indicating significant thiamine deficiency in patients with TAN compared to controls, and a placebo-controlled trial of therapeutic doses of thiamine which showed a clinically dramatic and statistically significant improvement in ataxia. "
4.	Wernicke Encephalopathy (Wernicke's Encephalopathy) 11/01/1986 - "We found that the above-mentioned patient and one of the diabetic kindreds with no history of Wernicke's encephalopathy had abnormal transketolase as determined by its Km for TPP. " 11/30/1990 - "The relationship between erythrocyte transketolase activity and the 'TPP effect' in Wernicke's encephalopathy and other thiamine deficiency states." 01/01/1986 - "Recent data demonstrating normal levels of erythrocyte transketolase in patients presenting with Wernicke's encephalopathy has led some to question the link between thiamin deficiency, and the development of the syndrome, despite the fact that virtually all patients with Wernicke's encephalopathy will respond favorably to parenteral thiamin, and the evidence that rats deprived of thiamin develop lesions that are characteristic of the disease. " 01/01/2022 - "The diagnosis of Wernicke encephalopathy in our patient is based on increased thiamine requirement due to pregnancy, nystagmus, low transketolase level, and reversal of symptoms after thiamine replacement. " 07/01/2002 - "Both patients were diagnosed with Wernicke's encephalopathy on clinical ground since there were no laboratory facilities to measure red cell transketolase and thiamine pyrophosphate levels. "
5.	Chronic Kidney Failure (Chronic Renal Failure) 01/01/2016 - "Decreased transketolase activity is an unexplained characteristic of patients with end-stage renal disease and is linked to impaired metabolic and immune function. " 06/01/2000 - "No correlation between erythrocyte TDP concentration and transketolase activity and/or alpha-ETK was observed in ESRD patients, either before or 10 h after administration. " 07/01/1984 - "[Catalytic activity of transketolase in erythrocytes in chronic kidney failure]." 11/01/1971 - " findings demonstrate that in patients with chronic renal failure, low molecular weight factors accumulate and inhibit nervous tissue transketolase. " 01/01/2016 - "The uremic toxin oxythiamine causes functional thiamine deficiency in end-stage renal disease by inhibiting transketolase activity."

Related Drugs and Biologics

1.	Thiamine (Aneurin)
2.	Enzymes
3.	Glucose (Dextrose)
4.	Pyruvic Acid (Pyruvate)
5.	NADP (NADPH)
6.	Transcription Factors (Transcription Factor)
7.	Poly (ADP-Ribose) Polymerase-1
8.	Oxidoreductases (Dehydrogenase)
9.	benphothiamine (benfotiamine)
10.	Hexokinase

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	Renal Dialysis (Hemodialysis)
4.	Drug Therapy (Chemotherapy)
5.	Neoadjuvant Therapy