Anti-Anxiety Agents (Anxiolytics)

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. Some are also effective as anticonvulsants, muscle relaxants, or anesthesia adjuvants. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.

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Networked: 400 relevant articles (17 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Möhler, Hanns: 3 articles (01/2015 - 09/2002)
2.	de Jong-van den Berg, Lolkje T W: 3 articles (07/2012 - 03/2009)
3.	Vestergaard, P: 3 articles (06/2012 - 07/2005)
4.	Fridlund, Bengt: 2 articles (11/2015 - 03/2015)
5.	Thvilum, Marianne: 2 articles (05/2014 - 02/2014)
6.	Almind, Dorthe: 2 articles (05/2014 - 02/2014)
7.	Brix, Thomas Heiberg: 2 articles (05/2014 - 02/2014)
8.	Hegedüs, Laszlo: 2 articles (05/2014 - 02/2014)
9.	Brandt, Frans: 2 articles (05/2014 - 02/2014)
10.	Christensen, Kaare: 2 articles (05/2014 - 02/2014)

Related Diseases

1.	Anxiety Disorders (Anxiety Disorder) 02/01/2005 - "Therefore, anxiety disorders may stem from an unopposed formation of aversive memories and clinically effective anxiolytics hinder the association between emotional and cognitive processing. " 11/01/1996 - "On the one hand, the selective serotonin-1A receptor partial agonist anxiolytics were developed first and represented a new class of pharmacological agents that have demonstrated efficacy in the treatment of generalized anxiety disorder (GAD). " 01/01/1989 - "The selective serotonin-1A receptor partial agonist anxiolytics represent a new class of pharmacologic agents that have demonstrated efficacy in the treatment of generalized anxiety disorder (GAD). " 01/01/2014 - "With regard to anxiety disorders, the viability of nonsedative anxiolytics based on the modulation of α2- and α3-subunit-containing GABAA receptors has been established in clinical proof-of-concept trials. " 01/01/2008 - "The literature on pharmacologic treatment of refractory anxiety disorders is small but growing and includes studies of augmentation strategies and non-traditional anxiolytics. "
2.	Panic Disorder (Panic Attack) 03/01/2004 - "Anxiolytics are useful in patients with panic disorders, and psychological interventions (eg, cognitive-behavioral therapy) are also valuable, mainly in patients in whom reassurance is not sufficient to avoid the misinterpretation of their symptoms. " 12/01/1995 - "This was in contrast to chronic treatment which decreased both avoidance variables at 0.5 and 1 mg/kg, defensive threat/attack responses at all doses, and predator assessment responses at 0.5 mg/kg. In addition, the latter treatment reduced post-predator potentiation of escape attempts at 2 mg/kg. These results (1) confirm previous findings with the BZPR full agonist chlordiazepoxide, indicating that these compounds generally attenuate antipredator defensive responses in Swiss-Webster mice; (2) support recent data indicating that panic-altering drugs modulate flight/escape reactions, and suggest that the primary mechanism of action of drugs with efficacy against panic disorder may involve neural systems controlling flight; (3) confirm that the MDTB may be useful for the investigation of panicolytic as well as anxiolytic agents." 01/01/1989 - "Serotonergic anxiolytics in the treatment of panic disorder: a controlled study with buspirone." 01/01/2006 - "[An additional short-term use of benzodiazepine anxiolytics at the initial stage of the treatment of panic disorders]." 12/01/1996 - "Treatment of acute Panic Attack involves administration of sedative anxiolytics, principally benzodiazepines (BZD). "
3.	Schizophrenia (Dementia Praecox) 12/30/2006 - "These findings suggest that OL is beneficial in the treatment of HRQL impairment in schizophrenia compared with RP, FGAs and CA. Special attention should be paid to specific predictors of HRQL efficacy for each antipsychotic agent, and to concomitant treatment with antidepressants and anxiolytics." 03/01/2007 - "The purpose of this study was to determine the rates at which adjunctive antidepressants, mood stabilizers and anxiolytics were prescribed to black patients and white patients with schizophrenia. " 03/01/2007 - "Antidepressants, mood stabilizers and anxiolytics are frequently used in addition to antipsychotic medications in order to control ancillary symptom complexes among patients with schizophrenia. " 08/01/2006 - "Clinicians can now apply the knowledge of serotonergic modulation of neuroleptic action to the treatment of schizophrenic patients by using selected serotonergic anxiolytics and antidepressants as adjuvants in the treatment of schizophrenia." 01/01/2002 - "Persons with schizophrenia were also prescribed more antidepressants (increased from 18.5% in 1995 to 35.6% in 1999), anxiolytics (increased from 19.9% to 33.5%), and mood stabilizers (increased from 17.7% to 30.0%). "
4.	Sleep Initiation and Maintenance Disorders (Insomnia) 10/01/1981 - "[Effect of various anxiolytics on sleep, apropos of the polygraph study of a case of insomnia]." 10/01/1986 - "Anxiety and insomnia are prevalent conditions in the elderly, and anxiolytics and hypnotic drugs are commonly used. " 01/01/1982 - "Anxiolytics without impairment of performance during the day have obvious clinical advantages, and if they also have a useful hypnotic activity they can be particularly appropriate for the management of insomnia secondary to anxiety." 10/01/1999 - "Results underscore the persistent general tendency among French general practitioners to overprescribe anxiolytics for the treatment of insomnia complaints and that they do so on a long-term basis, despite the findings of numerous studies showing that benzodiazepines are ineffective in the treatment of sleep complaints over the long term." 06/01/2012 - "Short-term supplementary medication with anxiolytics and hypnotics in the case of anxiety and insomnia is recommended. "
5.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 01/01/2006 - "For example, the effects of anxiolytics and 5-HT-active compounds, including those used clinically for obsessive-compulsive disorder (OCD), can be detected. " 09/01/1996 - "Reported placebo response levels in clinical studies of anxiolytics for generalized anxiety disorder and panic disorder vary widely, with a tendency to be rather high, although studies in social phobia and obsessive compulsive disorder appear to have consistently low placebo response rates. " 01/01/1996 - "The concept of antidepressants is changing rapidly as these agents appear with new therapeutic indications other than depression, such as panic disorder, obsessive compulsive disorder, etc. It can be expected that the presently available antidepressants might eventually be considered anxiolytics or that benzodiazepines and 5-HT1A agonists could come to be viewed as disinhibiting substances." 02/28/2003 - "However, compounds (triazolobenzodiazepines such as adinazolam and alprazolam, selective serotonin reuptake inhibitors) that have a different spectrum of therapeutic efficacy in anxiety disorders such as panic attacks, generalized anxiety disorder or obsessive-compulsive disorder were poorly effective as anxiolytics in the open field test, suggesting that this paradigm may not model features of anxiety disorders. " 05/01/2012 - "Search terms included the following, individually and in combination: psychiatry, athletes, elite athletes, professional athletes, sports, sport psychiatry, mental illness, major depressive disorder, depression, bipolar disorder, suicide, anxiety, generalized anxiety disorder, obsessive compulsive disorder, social phobia, social anxiety disorder, panic disorder, post traumatic stress disorder, specific phobia, psychosis, eating disorders, anorexia nervosa, bulimia nervosa, attention deficit hyperactivity disorder, substance abuse, substance dependence, addiction, alcohol, anabolic steroids, stimulants, antidepressants, mood stabilizers, anxiolytics, antipsychotics, sedative-hypnotics, psychotropics, medications, and psychiatric medications. "

Related Drugs and Biologics

1.	Antidepressive Agents (Antidepressants)
2.	Hypnotics and Sedatives (Sedatives)
3.	Antipsychotic Agents (Antipsychotics)
4.	Benzodiazepines
5.	Alprazolam (Xanax)
6.	Buspirone (Buspar)
7.	Risperidone (Risperdal Consta)
8.	olanzapine (Zyprexa)
9.	Serotonin (5 Hydroxytryptamine)
10.	Anticonvulsants (Antiepileptic Drugs)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Induced Hyperthermia (Thermotherapy)
4.	Injections
5.	Analgesia