Trachoma

03/01/2014 - "Mass oral azithromycin distributions have dramatically reduced the prevalence of the ocular strains of chlamydia that cause trachoma. "
11/01/2004 - "Azithromycin is highly effective against trachoma, but the practical difficulties of community-wide distribution often leave many individuals untreated. "
01/01/2012 - "Mass treatment with azithromycin to control trachoma can be considered cost effective in the African but not the South East Asian sub-region. "
01/01/2009 - "Repeated mass azithromycin distributions are effective in controlling the ocular strains of chlamydia that cause trachoma. "
11/01/2002 - "Azithromycin (Zithromax, Pfizer Inc., New York, NY, USA) is effective in the control of blinding trachoma. "

01/01/2015 - "There is evidence from one trial that face washing combined with topical tetracycline may be effective in reducing severe active trachoma and in increasing the prevalence of clean faces at one year follow-up. "
01/01/2012 - "There is some evidence that face washing combined with topical tetracycline can be effective in reducing severe trachoma and in increasing the prevalence of clean faces. "
01/01/2004 - "There is some evidence that face washing combined with topical tetracycline can be effective in reducing severe trachoma and in increasing the prevalence of clean faces. "
01/01/2015 - "The second trial compared eye washing to no treatment or to topical tetracycline alone or to a combination of eye washing and tetracycline drops in children with follicular trachoma. "
01/01/2015 - "The trial found that face washing combined with topical tetracycline reduced 'severe' active trachoma compared with topical tetracycline alone at 12 months (adjusted odds ratio (OR) 0.62, 95% confidence interval (CI) 0.40 to 0.97); however, the trial did not find any important difference between the intervention and control villages in reducing other types of active trachoma (adjusted OR 0.81, 95% CI 0.42 to 1.59). "

01/01/1959 - "By the early 1950's, it was clear from numerous independent reports that certain of the broad-spectrum antibiotics were effective against the agent of trachoma. "
03/01/2012 - "Improved health education and facial hygiene has been linked to a lower incidence of trachoma, but the evidence is less clear than for surgery and antibiotics. "
01/01/2008 - "However, few studies have evaluated the complete SAFE strategy, and of these, none have investigated the associations of Antibiotics, Facial cleanliness, and Environmental improvement (A,F,E) interventions and active trachoma. "
12/01/2006 - "Trachoma, antibiotics and randomised controlled trials."
11/01/2003 - "In 1985, the Edna McConnell Clark Foundation joined with the World Health Organization to support studies on trachoma epidemiology and control, resulting in the elaboration of the surgery, antibiotics, facial cleanliness and environmental improvement (SAFE) strategy as the basis for the elimination of this blinding disease. "

06/01/2011 - "If trachoma can be eradicated with repeated mass antibiotic distributions, it would encourage similar strategies against other bacterial diseases whose only host is humans and for which effective vaccines are not available."
01/01/1966 - "A review of the progress made by various workers in this field suggests that, although some vaccines now being tested are partially effective, much remains to be learned about immunity to trachoma and methods of inducing it artificially."
12/01/1971 - "Criteria for measuring the efficacy of trachoma vaccines in baboons."
08/01/2006 - "Currently there are no licensed vaccines for trachoma, and no human vaccine trials have been conducted since the 1960s. "
03/01/1979 - "A field trial of two high titer bivalent trachoma vaccines was done in a rural area of Northern India in children under the age of 6 years. "

04/09/1973 - "Doxycycline treatment of chronic trachoma."
04/01/1980 - "When treatment was continued for 12 months, a marked decrease in the prevalence of trachoma and in the grades of intensity of inflammatory responses as well as the positivity rate for Chlamydia trachomatis was observed in the groups treated with the topical oxytetracycline or oral doxycycline compared with the control group. "
01/01/1985 - "[Effect of oral doxycycline and 1% tetracycline ointment in the treatment of severe trachoma]."
04/01/1980 - "Family-based suppressive intermittent therapy of hyperendemic trachoma with topical oxytetracycline or oral doxycycline."
04/01/1980 - "While there was no marked difference between the efficacy of these 2 regimens of mass chemotherapy, the monthly intermittent therapy with a single dose of doxycycline offers the advantage of being more practical and less expensive for mass control of trachoma by requiring approximately one-tenth of the staff, transport, and other facilities required for the intermittent topical therapy with tetracycline eye ointment."

05/01/1967 - "Characterization of trachoma antigens protective against mouse toxicity."
10/01/1962 - "Immunofluorescent studies with trachoma and related antigens."
01/01/2014 - "Antibody responses to trachoma antigens declined significantly six months after drug treatment for most age groups. "
01/01/2014 - "Longitudinal analysis of antibody responses to trachoma antigens before and after mass drug administration."
01/01/2013 - "Collectively, our results argue that an efficacious subunit trachoma vaccine might require a combination of these antigens delivered in their native conformation."

01/01/1989 - "In the first study, we determined the trough tear and plasma levels of minocycline in patients with active trachoma 24 hours after an oral dose. "
01/01/1989 - "Minocycline levels in tears of patients with active trachoma."
01/01/1988 - "Minocycline effects in patients with active trachoma."
01/01/1988 - "In two consecutive prospective double-masked clinical trials that were carried out in two villages in Saudi Arabia, we assessed the effects of oral minocycline in the treatment of trachoma and compared its effects with those of topical tetracycline ointment in the first study and to tetracycline ointment and placebo in the second study. "
01/01/1988 - "Oral minocycline was found to be equally effective as topical tetracycline ointment in the treatment of trachoma at three weeks. "

09/01/1971 - "Tetracyclines in the treatment of chronic trachoma in American Indians."
04/01/1976 - "Since active inflammatory trachoma in childhood responds to tetracyclines, erythromycin, and sulphonamides the disease should be attacked in those undeveloped rural areas where it continues to lead to blindness."
12/01/1979 - "In a small field trial, chlorhexidine (50 micrograms/ml) was as effective against clinical trachoma as topical tetracyclines or oral co-trimoxazole; in vitro, 2.5 micrograms/ml was chlamydicidal."
01/01/1982 - "To maintain blood levels of antibiotics known to be effective in the treatment of chlamydial infections with a dosage schedule possible in a trachoma control programme, one of the long-acting tetracyclines (doxycycline or minocycline) might be considered. "

01/01/1994 - "In order to optimize the trachoma treatment duration, we carried out a prospective study to observe the disease course over a long period of treatment by a 1% oxytetracycline (chlorhydrate) suspension. "
01/01/1994 - "[Course of trachoma under treatment with 1% oxytetracycline ophthalmic solution]."
06/01/1965 - "2989 AND OXYTETRACYCLINE IN TRACHOMA."
01/01/1965 - "[Action of oxytetracycline on trachoma virus]."
01/01/1957 - "[Application of terramycin in trachoma]."

01/01/1971 - "[Study of serum antibodies in trachoma using Hoigné's method]."
01/01/1970 - "[Study of the fluorescent and precipitating agglutinating antibodies of the causative agent of trachoma (Chlamydia trachomatis) in the PLT group]."
09/01/2010 - "The diagnosis was performed according to the World Health Organization (WHO) protocol and patients with clinical trachoma detection were submitted to laboratory confirmation by direct smear fluorescent antibodies cytology for Chlamydia trachomatis. "
01/01/1999 - "Polyclonal antibodies (PAbs) were initially used for typing and were able to identify serovars D through K and LI, L2, and L3 as primarily genital pathogens, and serovars A, B, Ba, and C as trachoma pathogens. "
10/01/1994 - "psittaci, as shown by the high prevalence of chlamydial antibodies in the hyperendemic trachoma community studied."

05/01/1975 - "A controlled chemotherapy trial of trachoma was carried out in a Tunisian oasis among schoolchildren with active disease. "
01/01/1968 - "The evaluation of controlled trachoma chemotherapy trials."
01/01/2013 - "Improvements in hygiene and sanitation promoted both by the SAFE strategy for trachoma and health extension program combined with preventive chemotherapy during enhanced outreach services are plausible explanations for the changing patterns of intestinal parasite prevalence. "
01/01/2002 - "Current trachoma treatment methodologies: focus on advancements in drug therapy."
05/01/1999 - "Global elimination of trachoma: how frequently should we administer mass chemotherapy?"

01/01/2011 - "Oral administration of AZT is effective for the treatment of trachoma; however, topical formulations are difficult to develop because of the drug's hydrophobicity. "
01/01/2011 - "We included randomised trials that satisfied either of two criteria: (a) trials in which topical or oral administration of an antibiotic was compared to placebo or no treatment in people or communities with trachoma, (b) trials in which a topical antibiotic was compared with an oral antibiotic in people or communities with trachoma. "
01/01/2005 - "We included only randomised trials that satisfied either of two criteria: (a) trials in which topical or oral administration of an antibiotic was compared to placebo or no treatment in people with trachoma, (b) trials in which a topical antibiotic was compared with an oral antibiotic in people with trachoma. "
01/01/2002 - "We included only randomised trials that satisfied either of two criteria: (a) trials in which topical or oral administration of an antibiotic was compared to placebo or no treatment in people with trachoma, (b) trials in which a topical antibiotic was compared with an oral antibiotic in people with trachoma. "
04/01/2009 - "In ophthalmology, oral administration of azithromycin has been proven effective for the treatment of trachoma. "

06/01/1969 - "Keratoplasty and trachoma in the southwestern American Indian."
01/01/1966 - "[On the utilization of human preserved corneas in keratoplasty in trachoma areas]."
01/01/1964 - "[KERATOPLASTY AND TRACHOMA]."
10/01/2012 - "To evaluate the efficacy of automated lamellar therapeutic keratoplasty (ALTK) for the management of anterior corneal stromal scarring caused by trachoma. "
04/01/2009 - "To report on the results of visual rehabilitation by ipsilateral rotational keratoplasty (IRK) and cataract extraction in 17 patients with trachoma and with trachoma and trauma in Oman over 3 years. "

04/01/1999 - "The aim of this prospective study was to verify the efficacy of laser therapy for trichiasis in trachoma. "

01/01/1951 - "[Study of the growth of corneal grafts in trachoma]."
01/01/2011 - "The Fyodorov-Zuev keratoprosthesis was implanted in ten patients with repeated graft failures, including seven patients with old trachoma, two patients with chemical injury, and a patient with thermal injury. "
11/15/1985 - "A 70-year-old man underwent oral mucous membrane grafts to the right eye for presumed trachoma at the ages 26 and 32 years. "
03/01/1978 - "Classification of trachoma by site rather than density of opacities is better related to visual prognosis and helps in selection for graft surgery. "
07/01/2012 - "Over the study period, there was a significant increase in the relative frequency of infectious corneal ulcers, failed grafts, and trachoma keratopathy. "