Trachoma

03/01/2014 - "Mass oral azithromycin distributions have dramatically reduced the prevalence of the ocular strains of chlamydia that cause trachoma. "
11/01/2004 - "Azithromycin is highly effective against trachoma, but the practical difficulties of community-wide distribution often leave many individuals untreated. "
01/01/2018 - "Repeated oral azithromycin distribution targeted only to children has proven effective in reducing the ocular Chlamydia that causes trachoma. "
01/01/2019 - "The lack of resistance in Chlamydia trachomatis suggests that azithromycin might remain effective for trachoma programmes, but evidence is scarce. "
03/02/2012 - "Mass treatment with azithromycin to control trachoma can be considered cost effective in the African but not the South East Asian sub-region. "

03/01/2014 - "Assessing efficacy of the antibiotic in an individual is important in planning trachoma elimination. "
01/01/1959 - "By the early 1950's, it was clear from numerous independent reports that certain of the broad-spectrum antibiotics were effective against the agent of trachoma. "
03/28/2009 - "Assessment of herd protection against trachoma due to repeated mass antibiotic distributions: a cluster-randomised trial."
02/01/2017 - "Improvement in socioeconomic and living conditions, availability of antibiotics, and introduction of National Trachoma Control Programmes reduced the prevalence in developed countries, but it persisted in resource-poor settings of Africa and Asia, including India. "
12/22/2012 - "Improvement in awareness of facial hygiene, environmental conditions, mass antibiotic distribution and health education on trachoma transmission and prevention should be strengthened in the District."

02/20/2015 - "There is evidence from one trial that face washing combined with topical tetracycline may be effective in reducing severe active trachoma and in increasing the prevalence of clean faces at one year follow-up. "
04/18/2012 - "There is some evidence that face washing combined with topical tetracycline can be effective in reducing severe trachoma and in increasing the prevalence of clean faces. "
01/01/2004 - "There is some evidence that face washing combined with topical tetracycline can be effective in reducing severe trachoma and in increasing the prevalence of clean faces. "
02/20/2015 - "The second trial compared eye washing to no treatment or to topical tetracycline alone or to a combination of eye washing and tetracycline drops in children with follicular trachoma. "
02/20/2015 - "The trial found that face washing combined with topical tetracycline reduced 'severe' active trachoma compared with topical tetracycline alone at 12 months (adjusted odds ratio (OR) 0.62, 95% confidence interval (CI) 0.40 to 0.97); however, the trial did not find any important difference between the intervention and control villages in reducing other types of active trachoma (adjusted OR 0.81, 95% CI 0.42 to 1.59). "

05/01/2008 - "Thus, an inexpensive and easy to deliver vaccine for trachoma would be highly effective in reducing the devastation caused by this disease. "
10/01/2018 - "No vaccine has yet proven effective against the ocular strains of chlamydia that cause trachoma. "
01/01/2018 - "Also, the promising results from vaccine testing in animal models could lead to human vaccines against trachoma and reproductive diseases simultaneously."
01/01/1966 - "A review of the progress made by various workers in this field suggests that, although some vaccines now being tested are partially effective, much remains to be learned about immunity to trachoma and methods of inducing it artificially."
06/15/2009 - "The objective of this study was to investigate the immunogenicity and vaccine efficacy of Chlamydia trachomatis nMOMP in a nonhuman primate trachoma model. "

11/01/1976 - "In patients with trachoma (18) and paratrachoma (4) cure was achieved by topical application of 5% ointment. "
01/01/1965 - "A new eye ointment in treatment of trachoma."
01/01/1985 - " The investigators suggest that health authorities in the area distribute trachoma prophylaxis (antibiotic eye ointment) to all school age children."
02/01/1995 - "In our study, Ofloxacin eye ointment has been proved to be an alternative drug for severe trachoma with better curative effectiveness."
12/01/2014 - "Face washing plus topical tetracycline eye ointment gave no additional protective benefit against active trachoma when compared with topical tetracycline eye ointment alone. "

10/01/1975 - "Thus, antigen 0.65 appears to be a Trachoma-LGV-specific antigen that has considerable promise for serodiagnosis."
05/01/1967 - "Characterization of trachoma antigens protective against mouse toxicity."
10/01/1962 - "Immunofluorescent studies with trachoma and related antigens."
04/22/2014 - "Antibody responses to trachoma antigens declined significantly six months after drug treatment for most age groups. "
11/01/2009 - "trachomatis antigen by analyzing these responses in 64 Gambian twin pairs from trachoma endemic areas. "

02/15/2012 - "There is some evidence from two trials that insecticides are effective in reducing trachoma, however, this effect was not demonstrated in another trial that used insecticides. "
02/15/2012 - "However, another study did not find insecticide spray to be effective in reducing trachoma. "
10/17/2007 - "However, another study did not find insecticide spray to be effective in reducing trachoma. "
07/01/2022 - "Evaluation of the efficacy of insecticide-treated scarves to protect children from the trachoma vector Musca sorbens (Diptera: Muscidae): A phase II randomised controlled trial in Oromia, Ethiopia."
02/15/2012 - "Two studies that assessed insecticide spray as a fly control measure found that trachoma is reduced by at least 55% to 61% with this measure compared to no intervention. "

04/09/1973 - "Doxycycline treatment of chronic trachoma."
04/01/1980 - "When treatment was continued for 12 months, a marked decrease in the prevalence of trachoma and in the grades of intensity of inflammatory responses as well as the positivity rate for Chlamydia trachomatis was observed in the groups treated with the topical oxytetracycline or oral doxycycline compared with the control group. "
04/01/1980 - "Family-based suppressive intermittent therapy of hyperendemic trachoma with topical oxytetracycline or oral doxycycline."
11/01/1985 - "Moreover, the use of oral antibiotics (either tetracycline or doxycycline) in selected cases is a cost-effective strategy, particularly in communities where less than 20% of children have active trachoma. "
01/01/1985 - "[Effect of oral doxycycline and 1% tetracycline ointment in the treatment of severe trachoma]."

01/01/1956 - "Study of trachoma virus; electron-microscopic study of the conjunctival suspension of human trachoma."
01/01/2005 - "Using the standardised schedule, 97.7% of children aged 6 to 59 months receiving oral suspension and 96.7% of children aged 60 months to 15 years receiving tablets would have received treatment within a dosage range of 20-40 mg/kg. Less than 1% of all children would have received treatment less than 20 mg/kg. These findings suggest that the schedule presented in this paper is likely to yield safe and effective treatment for a broad range of populations vulnerable to trachoma while substantially improving the efficiency of height-based treatment."
02/21/2000 - "All children with acute trachoma and their contacts (co-resident siblings aged between 6 months and 15 years) received single-dose oral azithromycin suspension (20 mg/kg, to a maximum of 1000 mg). "
11/22/1963 - "TRACHOMA AGENT: GLUCOSE UTILIZATION BY PURIFIED SUSPENSIONS."
11/18/1950 - "Trachoma; aureomycin (oily suspension) in its out-patient treatment."

10/01/2005 - "There appears to be a clear need to retrain middle cadre ivermectin workers in trachoma rapid assessment and SAFE strategy intervention methods in order to further impact blindness prevention in these 'onchocerciasis-endemic' zones."
03/01/2008 - "The Ministry of Health is successfully controlling onchocerciasis through community-directed treatment with ivermectin and has implemented health system changes that would allow extension of integrated NTD control to schistosomiasis, lymphatic filariasis, soil-transmitted helminthiasis and trachoma. "
10/01/1993 - "Ivermectin must be taken annually to sustain protection against blindness, thus its incorporation into primary health care along with malaria, AIDS, trachoma, xerophthalmia, and cataract is most cost effective. "
01/01/2019 - "Ivermectin-based mass drug administration can be scaled to a population of over 25 000 with high efficacy and this level of efficacy can be achieved when mass drug administration for scabies is integrated with mass drug administration of azithromycin for trachoma. "
09/01/2008 - "The recent decision to extend the APOC up to 2015 should facilitate the building of sustainable Mectizan treatment programmes that are integrated with the control of other neglected tropical diseases, such as lymphatic filariasis, intestinal helminths and trachoma. "

03/01/1966 - "Trachoma therapy: a controlled study."
02/01/1962 - "[Trial therapy of trachoma with sulfophenylpyrazol]."
09/01/1953 - "[Trial therapy of trachoma from the viewpoint of prevention]."
04/01/2011 - "Therapy for trachoma had barely advanced from the measures used by the ancient Egyptian, Greek, and Roman physicians. "
09/01/2009 - "The prevalence, risk factors, diagnosis, preventive and therapy of trachoma are summarized in the paper."

01/01/2018 - "A significant reduction in the overall prevalence of follicular trachoma was achieved after two rounds of mass drug administration. "
11/01/2021 - "This study assessed the effectiveness of Mass Drug Administration (MDA) through an ethnographic study of trachoma amongst a Maasai community. "
01/01/2020 - "The prevalence of active trachoma was high in the study area and showed a significant variation between graduated and non-graduated districts with mass drug administration. "
01/01/2018 - "However, none of these studies has directly compared age seroprevalence in the same communities before and after mass drug administration (MDA) for trachoma. "
04/01/2013 - "Can we stop mass drug administration prior to 3 annual rounds in communities with low prevalence of trachoma?: PRET Ziada trial results."

05/01/1975 - "A controlled chemotherapy trial of trachoma was carried out in a Tunisian oasis among schoolchildren with active disease. "
01/01/1968 - "The evaluation of controlled trachoma chemotherapy trials."
01/01/2013 - "Improvements in hygiene and sanitation promoted both by the SAFE strategy for trachoma and health extension program combined with preventive chemotherapy during enhanced outreach services are plausible explanations for the changing patterns of intestinal parasite prevalence. "
01/01/2002 - "Current trachoma treatment methodologies: focus on advancements in drug therapy."
05/01/1999 - "Global elimination of trachoma: how frequently should we administer mass chemotherapy?"

01/01/2011 - "Oral administration of AZT is effective for the treatment of trachoma; however, topical formulations are difficult to develop because of the drug's hydrophobicity. "
04/01/2009 - "In ophthalmology, oral administration of azithromycin has been proven effective for the treatment of trachoma. "
01/01/2019 - "We included randomised controlled trials (RCTs) that satisfied either of two criteria: (a) trials in which topical or oral administration of an antibiotic was compared to placebo or no treatment in people or communities with trachoma, (b) trials in which a topical antibiotic was compared with an oral antibiotic in people or communities with trachoma. "
03/16/2011 - "We included randomised trials that satisfied either of two criteria: (a) trials in which topical or oral administration of an antibiotic was compared to placebo or no treatment in people or communities with trachoma, (b) trials in which a topical antibiotic was compared with an oral antibiotic in people or communities with trachoma. "
04/18/2005 - "We included only randomised trials that satisfied either of two criteria: (a) trials in which topical or oral administration of an antibiotic was compared to placebo or no treatment in people with trachoma, (b) trials in which a topical antibiotic was compared with an oral antibiotic in people with trachoma. "

06/01/1969 - "Keratoplasty and trachoma in the southwestern American Indian."
01/01/1966 - "[On the utilization of human preserved corneas in keratoplasty in trachoma areas]."
01/01/1964 - "[KERATOPLASTY AND TRACHOMA]."
10/01/2012 - "To evaluate the efficacy of automated lamellar therapeutic keratoplasty (ALTK) for the management of anterior corneal stromal scarring caused by trachoma. "
01/01/2021 - "Corneal scarring due to old trachoma was the leading indication for keratoplasty 20 years ago in Bahrain. "