Toyocamycin

4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.

Also Known As:

Networked: 15 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cho, Youl-Hee: 2 articles (05/2006 - 06/2005)
2.	Lee, Chul-Hoon: 2 articles (05/2006 - 06/2005)
3.	Kim, Min Kyoung: 2 articles (05/2006 - 06/2005)
4.	Wnuk, Stanislaw F: 1 article (09/2014)
5.	Balzarini, Jan: 1 article (09/2014)
6.	Ortiz, Heysell: 1 article (09/2014)
7.	Young, James D: 1 article (09/2014)
8.	Rayala, Ramanjaneyulu: 1 article (09/2014)
9.	Robins, Morris J: 1 article (09/2014)
10.	Yao, Sylvia: 1 article (09/2014)

Related Diseases

1.	Leukemia 07/01/1982 - "We have previously shown that toyocamycin depresses the production of the Friend leukemia viral complex by chronically infected cells. " 03/01/1970 - "Influence of toyocamycin on avian leukemia myeloblasts: cell growth, ultrastructure, RNA synthesis, and elaboration of BAI strain A virus." 06/08/2005 - "The purpose of the present study was to investigate the anti-proliferative and apoptotic effects of MCS-C2, a novel synthetic analogue of the pyrrolo[2,3-d]pyrimidine nucleoside toyocamycin and sangivamycin, in human promyelocytic leukemia (HL-60) cells. "
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2001 - "When compared to the parent toyocamycin, all these analogues showed much lower cytotoxicity to human prostate cancer cells (HTB-81), mouse melanoma cancer cells (B16) as well as normal human fibroblasts. " 05/01/2006 - "The purpose of the present study was to investigate the mechanisms involved in the antiproliferative and apoptotic effects of MCS-C2, a novel analog of the pyrrolo[2,3-d]pyrimidine nucleoside toyocamycin and sangivamycin, in human prostate cancer LNCaP cells. "
3.	Ascites 06/28/1977 - "The present study shows that the antitumor agent toyocamycin (4-amino-5-cyano-7beta-D-ribofuranosylpyrrolo(2-3d)pyrimidine) affects rRNA transcription in Ehrlich ascites cells. " 02/15/1982 - "In BHK21 cells fluorodeoxyuridine has no effect on either rRNA maturation or transcription, whereas toyocamycin (at 2 microM) inhibits both processes in BHK21 cells and Ehrlich ascites cells. "
4.	Starvation 06/28/1977 - "Processing of the 45S rRNA precursor is markedly inhibited by toyocamycin in cells incubated in either medium, indicating that the uptake of the drug is unimpaired by amino acid starvation. " 01/20/1977 - "After starvation for adenosine, toyocamycin is incorporated into pre-rRNA chains of SY15ado cells replacing adenosine residues. "
5.	Neoplasms (Cancer) 09/01/2014 - "Type-specific inhibition of cancer cell proliferation was observed at micromolar concentrations with the 4-N-(4-nitrobenzyl) derivatives of sangivamycin and toyocamycin, and also with 4-N-benzyltubercidin. " 01/01/2001 - "In order to overcome the weakness of these nucleoside analogues, substitution of a variety of modified sugars for the ribofuranose was explored in our laboratories with expectation that certain sugar-modified toyocamycin analogues may be selectively cytotoxic to cancer cells. " 01/01/2001 - "When compared to the parent toyocamycin, all these analogues showed much lower cytotoxicity to human prostate cancer cells (HTB-81), mouse melanoma cancer cells (B16) as well as normal human fibroblasts. "

Related Drugs and Biologics

1.	sangivamycin
2.	MCS-C2
3.	pyrimidine
4.	Ribosomal RNA
5.	Tubercidin
6.	RNA (Ribonucleic Acid)
7.	Messenger RNA (mRNA)
8.	RNA Precursors (Precursor, mRNA)
9.	Ribosomal Proteins (Ribosomal Protein)
10.	Fluorouracil (Carac)