Tooth Resorption

Resorption of calcified dental tissue, involving demineralization due to reversal of the cation exchange and lacunar resorption by osteoclasts. There are two types: external (as a result of tooth pathology) and internal (apparently initiated by a peculiar inflammatory hyperplasia of the pulp). (From Jablonski, Dictionary of Dentistry, 1992, p676)

Also Known As:

Networked: 25 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Periodontal Diseases (Periodontal Disease)
2.	Neoplasms (Cancer)
3.	Chronic Kidney Failure (Chronic Renal Failure)
4.	Ankylosis

Experts

1.	Reiter, Alexander M: 3 articles (11/2014 - 07/2005)
2.	Harvey, Colin E: 2 articles (01/2009 - 06/2008)
3.	Lewis, John R: 2 articles (06/2008 - 07/2005)
4.	Okuda, Ayako: 2 articles (06/2008 - 07/2005)
5.	Soltero-Rivera, Maria M: 1 article (11/2014)
6.	Sonoda, Celso Koogi: 1 article (01/2014)
7.	Saito, Célia Tomiko Matida Hamata: 1 article (01/2014)
8.	Panzarini, Sônia Regina: 1 article (01/2014)
9.	Poi, Wilson Roberto: 1 article (01/2014)
10.	Hamanaka, Elizane Ferreira: 1 article (01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tooth Resorption:

1.	Alendronate (Alendronate Sodium)FDA LinkGeneric 01/01/2009 - "In addition, 10 cats with radiographic evidence of pre-existing tooth resorption (14 affected teeth) were treated with vehicle or 3.0 mg/kg alendronate per os once weekly for 22-weeks and, then, 9.0 mg/kg per os twice weekly for 27-weeks in a random, masked study. " 01/01/2009 - "Alendronate binds to tooth root surfaces and inhibits progression of feline tooth resorption: a pilot proof-of-concept study."
2.	Triamcinolone (Aristocort)FDA Link 07/01/1989 - "Recent studies have shown that application of a triamcinolone-containing medicament to the dental pulp cavity inhibits dentinoclast-mediated tooth resorption in vivo and in vitro. "
3.	Vitamin DFDA LinkGeneric 02/01/2010 - "However, increased expression of VDR protein, and the relative gene expression levels of 1alpha-hydroxylase and the VDR-target gene, 24-hydroxylase, indicated the involvement of an active vitamin D signalling in the pathophysiology of tooth resorption in cats." 07/01/2005 - "Chronic excess dietary vitamin D may be the long-sought cause of multiple tooth resorption in domestic cats. " 02/01/2010 - "Here, we investigated the expression of VDR, MSX2, and RANKL proteins, and the activity of the VDR-mediated signalling pathway (using the quantitative polymerase chain reaction on VDR target genes), in tooth resorption, and measured the serum levels of vitamin D metabolites in cats. " 02/01/2010 - "Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats."
4.	Messenger RNA (mRNA)IBA 11/01/2011 - "Changes in the expression of RANKL mRNA and the RANKL/OPG mRNA ratio are accompanied by a parallel alteration in the number of odontoclasts and tooth resorption, suggesting crucial involvement of RANKL and OPG in tooth resorption." 08/01/2002 - "The results also suggest that OPG and RANKL mRNA play a role in mediating inflammatory responses in gingival cells, and that OPG has an inhibiting effect on tooth resorption."
5.	Calcitriol Receptors (Calcitriol Receptor)IBA 02/01/2010 - "Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats."
6.	Interleukin-6 (Interleukin 6)IBA 04/01/2012 - "In conclusion, we propose that TR(+) PBMCs when cultured on bone are sensitive to 1,25(OH)(2)D, whereas the differentiation of TR(-) PMBCs on bone seem more sensitive to IL-6, suggesting that osteoclast precursors from cats with and without tooth resorption respond differently to osteoclast stimulating factors." 04/01/2012 - "Osteoclast progenitors from cats with and without tooth resorption respond differently to 1,25-dihydroxyvitamin D and interleukin-6." 04/01/2012 - "We studied the effect of 1,25-dihydroxycholecalciferol (1,25(OH)(2)D), and interleukin-6 (IL-6), on the formation and activity of feline osteoclasts, using peripheral blood mononuclear cells (PBMCs) from cats with and without tooth resorption (TR(+) and TR(-)) as a source of osteoclast precursors. "
7.	Proteins (Proteins, Gene)IBA 02/01/2010 - "Here, we investigated the expression of VDR, MSX2, and RANKL proteins, and the activity of the VDR-mediated signalling pathway (using the quantitative polymerase chain reaction on VDR target genes), in tooth resorption, and measured the serum levels of vitamin D metabolites in cats. "
8.	HLA-DR Antigens (HLA-DR)IBA 03/01/1998 - "These data suggest that the HLA-DR-immunopositive cells in the coronal pulp of human deciduous teeth play an inductive role in the differentiation, migration and/or activation of the odontoclasts and cementoblast-like cells during the stages of tooth resorption."
9.	Cholecalciferol (Vitamin D3)FDA Link 01/01/2010 - "It has been suggested that tooth resorption (TR) in cats is associated with vitamin D3 status. " 01/01/2010 - "Tooth resorption and vitamin D3 status in cats fed premium dry diets."
10.	Calcium OxalateIBA 03/01/1982 - "Deposition of calcium oxalate in the periodontium with accompanying bone loss and tooth resorption, occurred in a 55-year-old woman on long-term renal dialysis for end-stage renal disease. "

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 04/01/1987 - "Tooth resorption in the two-stage transplantation technique: a case report." 07/01/1983 - "Tooth resorption in the two-stage transplantation technique--a case report."
2.	Orthodontic Extrusion 06/01/2008 - "Significant association between tooth extrusion and tooth resorption in domestic cats."
3.	Traction 03/01/2013 - "(In this research, a broad definition of "ankylosis" was used, to include impacted canines immobilized a priori or during traction, due to all the possible causes that could contribute to immobilization, such as all types of external tooth resorption and other known or unknown factors.) Thirty-eight canines erupted spontaneously after space gaining, and the other 119 were treated surgically with an open (57 cases) or a closed (62 cases) exposure technique. "
4.	Tooth Movement 03/01/2001 - "These results indicated that during tooth movement CK is synthesized in odontoclasts on the pressure side and secreted into the tooth resorption lacunae. "
5.	Tooth Extraction (Tooth Extractions) 11/01/2014 - "Tooth extraction is predominantly performed in cats with tooth resorption, chronic gingivostomatitis and periodontal disease. "