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Tooth Abnormalities

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Congenital absence of or defects in structures of the teeth.

Also Known As:

Abnormalities, Teeth; Abnormalities, Tooth; Teeth Abnormalities; Abnormality, Teeth; Abnormality, Tooth; Odontomes; Teeth Abnormality; Tooth Abnormality; Odontome

Networked: 24 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Stomatognathic Diseases: 372
- Tooth Diseases: 15
  - Tooth Abnormalities: 24
- Stomatognathic System Abnormalities
  - Tooth Abnormalities: 24
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 668
- Congenital Abnormalities: 15467
  - Stomatognathic System Abnormalities
    - Tooth Abnormalities: 24

Related Diseases

1.	Lipomatosis
2.	Congenital Abnormalities (Deformity)
3.	Chloracne
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
5.	Premature Birth (Birth, Premature)

Experts

1.	Bansal, Samriti: 1 article (11/2014)
2.	Goyal, Puneet: 1 article (11/2014)
3.	Kaur, Harsimrit: 1 article (11/2014)
4.	Bansal, Ravinder Nath: 1 article (11/2014)
5.	Mohan Kumar, Rangarajan Sundaresan: 1 article (09/2013)
6.	Srinivasan, Ramasamy: 1 article (09/2013)
7.	Jaya, Ranganathan: 1 article (09/2013)
8.	Pragasam, Vijendran: 1 article (07/2013)
9.	Verma, Rajesh: 1 article (07/2013)
10.	Vasudevan, Biju: 1 article (07/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tooth Abnormalities:

1.	Fenofibrate (CiL)FDA LinkGeneric 02/01/2013 - "Tooth abnormalities including accelerated tooth formation or eruption, macrodontia, and root hypoplasia are common in CIL-F." 02/01/2013 - "In total, 21 cases with tooth abnormalities in CIL-F were retrieved for analysis. " 02/01/2013 - "Tooth abnormalities in CIL-F documented in the English literature are also reviewed. " 02/01/2013 - "The aim of this study was to present a literature review and case series report of tooth abnormalities in congenital infiltrating lipomatosis of the face (CIL-F). "
2.	Hypohidrotic Ectodermal DysplasiaIBA 04/01/2012 - "In humans, inactivating mutations in the Eda pathway components lead to hypohidrotic ectodermal dysplasia (HED), a syndrome characterized by sparse hair, tooth abnormalities, and defects in several cutaneous glands. " 05/01/2013 - "X-linked hypohidrotic ectodermal dysplasia (XLHED) is characterised by hypohidrosis, sparse hair, and teeth abnormalities. "
3.	bromfenacoum (Talon)IBA 09/01/2013 - "A rare case of dilated invaginated odontome with talon cusp in a permanent maxillary central incisor diagnosed by cone beam computed tomography." 01/01/2005 - "The term to describe this situation in the anterior teeth is not clearly defined in the relevant literature, which employs various names such as talon cusp, accentuated cingulum (when it affects the lingual or palatal surface) or dens evaginatus (evaginated tooth, evaginated odontome), the term that is always used when it is present in the posterior teeth."
4.	Growth Differentiation Factor 5IBA 06/01/2004 - "Angel shaped phalangeal dysplasia, hip dysplasia, and positional teeth abnormalities are part of the brachydactyly C spectrum associated with CDMP-1 mutations."
5.	Connexin 43 (Connexin43)IBA 06/01/2010 - "To assess the role of Cx43 in tooth development we employ a mouse model of ODDD that harbors a G60S Cx43 mutant, Gja1(Jrt)/+, and appears to exhibit tooth abnormalities that mimic the human disease. "
6.	Biological Markers (Surrogate Marker)IBA 05/01/2013 - "Diagnosis occurs most frequently during adolescence and teeth abnormalities were the most frequent clinical marker of XLHED." 05/01/2013 - "Teeth abnormalities occurred in 79% of all cases and 52% of molecularly-confirmed cases as a primary clinical marker. "
7.	Vitamin D FDA LinkGeneric 12/01/2002 - "These findings suggest that while the Hyp bone and teeth abnormalities partially correct after PHEX gene transfer, additional factors and/or sites of PHEX expression are likely critical for the elaboration of the appropriate molecular signals that alter renal phosphate handling and vitamin D metabolism in this disorder."
8.	Tetrachlorodibenzodioxin (TCDD)IBA 05/01/2008 - "These included prenatal high-level methylmercury (CH(3)Hg) exposure (delayed developmental milestones and cognitive, motor, auditory, and visual deficits), high-level prenatal exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), and related toxicants (neonatal tooth abnormalities, cognitive and motor deficits), maternal active smoking (delayed conception, preterm birth, fetal growth deficit [FGD] and sudden infant death syndrome [SIDS]) and prenatal environmental tobacco smoke (ETS) exposure (preterm birth), low-level childhood lead exposure (cognitive deficits and renal tubular damage), high-level childhood CH(3)Hg exposure (visual deficits), high-level childhood exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (chloracne), childhood ETS exposure (SIDS, new-onset asthma, increased asthma severity, lung and middle ear infections, and adult breast and lung cancer), childhood exposure to biomass smoke (lung infections), and childhood exposure to outdoor air pollutants (increased asthma severity). "
9.	SmokeIBA 05/01/2008 - "These included prenatal high-level methylmercury (CH(3)Hg) exposure (delayed developmental milestones and cognitive, motor, auditory, and visual deficits), high-level prenatal exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), and related toxicants (neonatal tooth abnormalities, cognitive and motor deficits), maternal active smoking (delayed conception, preterm birth, fetal growth deficit [FGD] and sudden infant death syndrome [SIDS]) and prenatal environmental tobacco smoke (ETS) exposure (preterm birth), low-level childhood lead exposure (cognitive deficits and renal tubular damage), high-level childhood CH(3)Hg exposure (visual deficits), high-level childhood exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (chloracne), childhood ETS exposure (SIDS, new-onset asthma, increased asthma severity, lung and middle ear infections, and adult breast and lung cancer), childhood exposure to biomass smoke (lung infections), and childhood exposure to outdoor air pollutants (increased asthma severity). "
10.	Proteins (Proteins, Gene)IBA 11/15/2009 - "Both Evc and Evc2 proteins localize to the basal bodies of primary cilia and analysis of an Ellis-van Creveld mouse model, which includes the limb shortening and tooth abnormalities of EvC patients, has demonstrated Hedgehog signaling defects in the absence of Evc. "

Therapies and Procedures

1.	Orthodontic Extrusion 11/01/2014 - "The pathologies were detected 7 years after trauma; surgical removal of odontome along with the dentigerous cyst was performed, followed by orthodontic extrusion of the impacted double-dilacerated permanent central incisor. "
2.	Transplants (Transplant) 01/15/1968 - "A compound composite odontome and a vital homogenous togth transplant in an eight-year-old boy."
3.	Transplantation (Transplant Recipients) 12/01/2007 - "The treatment consisted of surgical removal of the odontome, extraction of the primary canine (63) and left permanent canine (23), and transplantation of the permanent canine (23). "
4.	Traction 09/01/1988 - "Treatment consisted of surgical removal of the odontome and application of orthodontic traction to the unerupted tooth. "
5.	Prosthodontics 12/01/2007 - "This clinical report describes the prosthodontic management of a young patient who received chemoradiotherapy for neuroblastoma and subsequently developed tooth abnormalities. "