HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Tolmetin (Tolmetin Sodium)

A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.

Also Known As:

Tolmetin Sodium; McN-2559; Tolectin; Tolmetin Sodium, Anhydrous; Tolmetin Sodium, Dihydrate; Anhydrous Tolmetin Sodium; Dihydrate Tolmetin Sodium; McN 2559; McN2559; 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-

Networked: 124 relevant articles (16 outcomes, 20 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azoles: 413
    - Pyrroles: 16
      - Tolmetin: 124
        zomepirac: 94
        tolmetin glycinamide: 2
        AU 8001: 1
        1-methyl-5-(4-carboxybenzoyl)-1H-pyrrole-2-acetic acid
        4-fluoroketorolac
        4-hydroxyketorolac
        hydroxyzomepirac
        tolmetin glucuronide
        tolmetin-zinc complex
        zomepirac glucuronide

Experts

1.	Klepacz, Robert: 2 articles (09/2009 - 01/2008)
2.	Burdan, Franciszek: 2 articles (09/2009 - 01/2008)
3.	Szumilo, Justyna: 2 articles (09/2009 - 01/2008)
4.	Daya, Santy: 2 articles (03/2007 - 09/2006)
5.	Dairam, Amichand: 2 articles (03/2007 - 09/2006)
6.	Koç, Derya: 1 article (10/2015)
7.	Orun, Oya: 1 article (10/2015)
8.	Bingöl-Özakpınar, Özlem: 1 article (10/2015)
9.	Sağ-Erdem, Safiye: 1 article (10/2015)
10.	Erzincan, Pınar: 1 article (10/2015)

Related Diseases

1.	Rheumatoid Arthritis 05/01/1975 - "The results indicate that tolmetin affords symptomatic relief of rheumatoid arthritis; its use results in global improvement in 80 per cent of the patients, and a net improvement in one or more of the parameters used to assess disease activity in 100 per cent of the patients; it seems to be sufficiently safe to administer to patients over a long period of time; there was no evidence of severe toxicity of any kind; gastrointestinal side effects were uncommon, and epigastric distress, in particular, was not observed." 07/01/1983 - "The results of these long-term studies of patients with rheumatoid arthritis demonstrated that tolmetin is an effective antiinflammatory agent with an acceptable record of safety." 07/01/1983 - "Data from over 1000 patients with rheumatoid arthritis who received tolmetin sodium in double-blind and open studies have been pooled to assess long-term efficacy and safety. " 07/23/1977 - "The results of this study indicate that tolmetin is a useful addition to the therapeutic agents for the treatment of rheumatoid arthritis, because of its ability to reduce morning stiffness and its lack of side-effects." 05/01/1975 - "Results of a one-year trial of tolmetin in patients with rheumatoid arthritis."
2.	Osteoarthritis 07/01/1983 - "The results of this retrospective study of both RA and osteoarthritis patients show that tolmetin was as effective in geriatric patients as in nongeriatric patients. " 01/01/1977 - "A double-blind crossover study was carried out in 24 patients with osteoarthrosis of the hip or knee to compare the efficacy of a 1200 mg tolmetin daily dose with a 600 mg daily dose, each given for 2 weeks. " 02/01/1993 - "The patient had been taking tolmetin for osteoarthritis. " 07/01/1983 - "This retrospective evaluation of tolmetin therapy shows significant relief of the symptoms of both RA and osteoarthritis in a geriatric population and fails to reveal any unusual or serious conditions which would contraindicate its use in the elderly patient. " 07/01/1983 - "Average daily dose of tolmetin sodium was 1141 mg for patients with RA and 953 mg for patients with osteoarthritis. "
3.	Pain (Aches) 03/01/1985 - "To examine specifically the effect of tolmetin in controlling the pain and functional limitation in DJD of the spine, tolmetin was tested against placebo in a double-blind, two-segment, crossover study. " 05/01/1979 - "From these results, it was concluded that tolmetin sodium has a potent inhibitory activity on the pain-like responses induced by the chemical nociceptive stimuli and by the mechanical pressure stimulus of the inflamed tissue, especially on the writhing. " 05/01/1979 - "Tolmetin sodium produced a significant inhibition of the pain-like response induced by electrical stimulation of tooth pulp of dogs, but showed no effect when the methods of Haffner and D'Amour-Smith were applied to mice. " 05/01/1979 - "Effect of tolmetin sodium on the pain-like responses caused by various nociceptive stimuli was examined in experimental animals. " 03/01/1985 - "The results showed that tolmetin provided significantly greater relief of symptoms than placebo in virtually all measurements of joint pain and stiffness: tenderness, pain at rest, pain on motion, intensity of joint pain (P less than 0.001), and duration of morning stiffness (P = 0.002). "
4.	Arthritis (Polyarthritis) 12/01/2003 - "Arthritis had disappeared at the same time in both the aspirin and tolmetin groups (P = 0.675). " 05/28/1977 - "A comparison of tolmetin with aspirin in the treatment of osteo-arthritis of the knee." 03/01/1983 - "Aspirin remains the cornerstone of treatment for juvenile arthritis, although tolmetin may be more effective in controlling the fever of systemic-onset disease. " 12/01/2003 - "Twenty patients with arthritis were treated with tolmetin (25 mg/kg per day; group I) and 52 patients with arthritis and/or mild carditis were put on aspirin therapy (75-100 mg/kg per day) for 4-6 weeks (group II). " 04/01/1978 - "[Tolmetin (Tolectin) in the long-term therapy of progressive polyarthritis]."
5.	Arthralgia (Joint Pain) 03/01/1985 - "The results showed that tolmetin provided significantly greater relief of symptoms than placebo in virtually all measurements of joint pain and stiffness: tenderness, pain at rest, pain on motion, intensity of joint pain (P less than 0.001), and duration of morning stiffness (P = 0.002). " 07/01/1983 - "Symptoms responded rapidly to treatment with tolmetin, and both the inflammatory symptoms of RA and the joint pain and functional parameters of osteoarthritis showed improvement that was both statistically and clinically significant throughout the major course of therapy. "

Related Drugs and Biologics

1.	Aspirin (Acetylsalicylic Acid)
2.	Naproxen (Naprosyn)
3.	Sulindac (Copal)
4.	Tolmetin (Tolmetin Sodium)
5.	Prednisolone (Predate)
6.	Ibuprofen (Motrin)
7.	Fenoprofen (Fenoprofen Calcium)
8.	ethnor
9.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
10.	Antirheumatic Agents (DMARD)

Related Therapies and Procedures

1.	Cataract Extraction
2.	Oral Administration
3.	Intra-Arterial Injections
4.	Renal Dialysis (Hemodialysis)
5.	Aftercare (After-Treatment)