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Tolbutamide (Orinase)

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A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)

Also Known As:

Orinase; Apo-Tolbutamide; Apotex Brand of Tolbutamide; Artosin; Aventis Brand of Tolbutamide; Berlin-Chemie Brand of Tolbutamide; Diabetol; Diaval; Dolipol; Hoechst Brand of Tolbutamide; Orabet; Pfizer Brand of Tolbutamide; R.A.N. Brand of Tolbutamide; Rastinon; Tolbutamid R.A.N.; Valdecasas Brand of Tolbutamide; Yamanouchi Brand of Tolbutamide; Berlin Chemie Brand of Tolbutamide; Tolbutamide Aventis Brand; Tolbutamide Butamide Brand; Tolbutamide Hoechst Brand; Tolbutamide Pfizer Brand; Butamide Brand of Tolbutamide; Benzenesulfonamide, N-((butylamino)carbonyl)-4-methyl-

Networked: 674 relevant articles (15 outcomes, 44 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Medina, José M: 3 articles (11/2010 - 03/2005)
2.	Tabernero, Arantxa: 3 articles (11/2010 - 03/2005)
3.	Zou, Fei: 3 articles (05/2009 - 08/2007)
4.	Liu, I-M: 3 articles (05/2007 - 03/2005)
5.	Cheng, J-T: 3 articles (05/2007 - 03/2005)
6.	Cheng, Juei-Tang: 3 articles (11/2006 - 12/2002)
7.	Lin, Guanyang: 2 articles (01/2014 - 01/2013)
8.	Chen, Mengchun: 2 articles (01/2014 - 01/2013)
9.	Ma, Jianshe: 2 articles (01/2014 - 01/2013)
10.	Pan, Jianchun: 2 articles (01/2014 - 01/2013)

Related Diseases

1.	Diabetes Mellitus 03/01/1960 - "Tolbutamide-induced improvement in carbohydrate tolerance of young people with mild diabetes mellitus." 09/01/1970 - "A study of single dose tolbutamide therapy in diabetes mellitus." 05/01/1964 - "[CONTRIBUTION TO THE STUDY OF THE ORAL TOLBUTAMIDE RESPONSE TEST IN THE DIAGNOSIS OF DIABETES MELLITUS]." 03/01/1964 - "[CONTRIBUTION TO THE STUDY OF THE TOLBUTAMIDE TEST IN THE DETECTION OF DIABETES MELLITUS]." 11/01/1963 - "[CONTRIBUTION TO THE STUDY OF THE TOLBUTAMIDE TEST IN THE INVESTIGATION OF DIABETES MELLITUS]."
2.	Hypoglycemia (Reactive Hypoglycemia) 09/01/1992 - "The present study investigated the teratogenicity of the oral hypoglycemic agent, tolbutamide, using an in vitro approach, and evaluated the role of its main metabolic effect, hypoglycemia. " 07/10/1957 - "Studies on the mechanism of tolbutamide hypoglycemia in animal and human subjects." 07/01/2015 - "In conclusion, tolbutamide treatment during the late embryonic development in broilers resulted in prolonged hypoglycemia in this period and negatively influenced the posthatch performance." 09/01/1992 - "Thus, tolbutamide produces malformation in mouse embryos in vitro at concentrations comparable to those in human serum, and the effects do not appear to be mediated by hypoglycemia. " 03/01/1988 - "Recurrent sulfonylurea induced nocturnal hypoglycemia managed with tolbutamide."
3.	Hyperglycemia 12/29/1960 - "Report of a case with an untoward response to tolbutamide and with a study of the possible mechanism of postoperative hyperglycemia." 01/01/1992 - "Tolbutamide and eight of the studied plants decreased significantly the hyperglycemia as compared with control test (water) (p < 0.05). " 05/01/1961 - "[Hyperglycemia following prolonged administration of elevated doses of tolbutamide to turtles]." 12/01/2007 - "At doses of 200-800 mg/kg, DGTS improved hyperglycemia in the rats, and the hypoglycemic effect of DGTS was comparable to that of tolbutamide. " 03/01/2011 - "The gastric responses to hyperglycemia and tolbutamide were not observed in rats with Kir6.2 small interfering RNA-treated nodose ganglia. "
4.	Body Weight (Weight, Body) 01/01/2011 - "The extracts were administered for two weeks in different groups whereas tolbutamide (80 mg/kg body weight) was used as reference standard throughout study. " 01/01/2014 - "The results obtained were compared with the reference standard drug Tolbutamide (100mg/kg, body weight). " 05/17/2011 - "Different concentrations of warm BTI (60, 120 and 480 mg/ml), tolbutamide (reference drug: 22.5mg/kg body weight) and water (control) were orally administered to different groups of rats, and hypoglycaemic and antihyperglycaemic activities were assessed. " 10/01/2003 - "Group 2 received tolbutamide 500-mg/Kg body weight. " 01/01/1991 - "In the observational group, tolbutamide concentration depended significantly on the daily dose, time from dose to sampling, body weight, and age. "
5.	Neoplasms (Cancer) 11/01/1993 - "The purpose of this study was to determine if tolbutamide, a drug known to decrease gluconeogenesis in diabetes, could decrease gluconeogenesis in hepatocytes isolated from tumor-bearing rats. " 07/01/2008 - "CYP2C9 activity as measured by apparent oral clearance and urinary metabolic ratio following oral tolbutamide appear similar in people with and without cancer. " 11/01/1993 - "Tolbutamide inhibits gluconeogenesis in the tumor-influenced hepatocyte." 07/01/2013 - "Cancer mortality was markedly reduced in the patients on gliclazide and tolbutamide treatment. " 01/01/1967 - "[The effect of tolbutamide on blood cholesterol levels in tumor patients]."

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Glucose (Dextrose)
3.	Blood Glucose (Blood Sugar)
4.	Hypoglycemic Agents (Hypoglycemics)
5.	C-Peptide
6.	Carbutamide (Glucidoral)
7.	Glucagon (Glukagon)
8.	Arginine (L-Arginine)
9.	Growth Hormone (Somatotropin)
10.	Somatostatin (Somatotropin Release-Inhibiting Factor)

Related Therapies and Procedures

1.	Oral Administration
2.	Subcutaneous Injections
3.	Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
4.	Injections
5.	Intravenous Injections