Tissue Extracts

Preparations made from animal tissues or organs (ANIMAL STRUCTURES). They usually contain many components, any one of which may be pharmacologically or physiologically active. Tissue extracts may contain specific, but uncharacterized factors or proteins with specific actions.

Also Known As:

Networked: 593 relevant articles (10 outcomes, 52 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schmitt, Manfred: 13 articles (01/2014 - 01/2002)
2.	Harbeck, Nadia: 11 articles (11/2010 - 01/2002)
3.	Brünner, Nils: 7 articles (08/2013 - 01/2002)
4.	Foekens, John A: 6 articles (06/2014 - 01/2002)
5.	Diamandis, Eleftherios P: 6 articles (06/2014 - 05/2002)
6.	Kotzsch, Matthias: 5 articles (01/2014 - 03/2003)
7.	Kiechle, Marion: 5 articles (01/2014 - 08/2002)
8.	Magdolen, Viktor: 4 articles (01/2014 - 03/2004)
9.	Dorn, Julia: 4 articles (01/2014 - 06/2003)
10.	Christensen, Ib Jarle: 4 articles (01/2008 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2007 - "In present study it was shown that 31P NMR spectroscopy of PCA tumor tissue extracts may be used as reliable method for the assessment of the level of oxygenation as well as changes in energy metabolism in the experimental tumors. " 03/01/1982 - "These studies utilized xenoantisera raised against a pool of lung tumor extracts which were exhaustively adsorbed with normal serum and tissue extracts. " 05/01/1973 - "Carcinoembryonic antigenic activity of tissue extracts: a quantitative study of malignant and benign neoplasms, cirrhotic liver, normal adult and fetal organs." 06/01/2013 - "The DiAcSpm level in cancer and adjacent normal tissue extracts was compared, and its relationship with clinical stages of the diseases was analyzed. " 10/15/2011 - "This fit for purpose method is amenable to analysis of tumor tissue extracts, and should enable direct assessment of in vitro-in vivo relationships in animal models of cancer."
2.	Inflammation 01/01/2013 - "Targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to assess endothelial dysfunction, oxidative stress and inflammation markers in plasma and kidney tissue extracts. " 12/01/1979 - "Since local clearance of fibrin in vivo and fibrinolysis inhibitor activity from tissue extracts studied in vitro are more evident in TI mice than in AT mice, it appears that T cell fu;ction is important in modulating the tissue response during granulomatous inflammation." 12/11/2012 - "HDL is antiatherogenic because it extracts tissue cholesterol and reduces inflammation. " 12/01/2010 - "In the in vivo murine model, preventive administration of E durans significantly ameliorated clinical disease activity index (weight loss, fecal bleeding, and stool consistency), reduced myeloperoxidase concentration in colon tissue extracts, improved histologic scores of colonic inflammation, and inhibited colonic transcription of proinflammatory immune factors. " 03/07/2005 - "To identify pathogenic antigens relevant to immune-mediated granulomatous inflammation in sarcoidosis, we used a limited proteomics approach to detect tissue antigens that were poorly soluble in neutral detergent and resistant to protease digestion, consistent with the known biochemical properties of granuloma-inducing sarcoidosis tissue extracts. "
3.	Carcinoma (Carcinomatosis) 04/01/1999 - "Changes in the protein concentrations in serum and tissue extracts of tumour-bearing rats suggest that all members of rat macroglobulin family are disturbed during the development of the Walker carcinoma, though only alpha2MG and alpha1PAG were substantially elevated." 01/01/1983 - "Approximately one-third of the patients gave significant reactions with gastrointestinal carcinoma extracts compared with normal tissue extracts. " 08/01/1982 - "Tissue extracts from 18 oral carcinomas were tested in the leukocyte migration capillary technique (LMCT) against autologous leukocytes and against leukocytes of healthy matched controls. " 11/01/2001 - "In this study we have analyzed the circulating forms of MMP-9 and MMP-2 in serum samples of patients with colon carcinoma, as well as the enzymatic activities present in tissue extracts from surgical fragments (primary tumor and its paired healthy tissue). " 04/01/1976 - "The reactivity in the LMCT was manifest at protein concentrations of 300 and 400 mug/ml. The study indicates that in contrast to the LMCT, the LMAT cannot be used for detection of TCMH towards allogeneic hypernephroma tissue extracts in patients with renal carcinoma."
4.	Fibrosis (Cirrhosis) 08/01/1996 - "Tissue extracts containing DNA repair enzyme, O(6)-methylguanine-DNA methyltransferase, were prepared from liver biopsy samples from 41 patients with cirrhosis (10 viral (HBV and HCV), 17 alcohol and 14 autoimmune), 17 patients with non-cirrhotic diseased liver and 4 patients with histologically normal liver. " 10/01/1987 - "To determine whether histologic ABs reliably reflect asbestos fiber concentrations in asbestosis, we compared the concentration of ABs in histologic sections to concentrations of ABs and fibers in tissue extracts of 14 asbestos workers with nonspecific interstitial fibrosis. " 08/01/1996 - "Compared with untreated SHR or WKY, we found the following: (1) Systolic arterial pressure was normalized (P < .025) and LVH completely reversed (P < .025) in SHR, with no significant reduction in systolic arterial pressure or left ventricular mass in WKY; (2) morphometrically determined myocardial fibrosis in SHR was significantly reversed (P < .025) and associated with improved diastolic stiffness (P < .05), which was measured in the isolated heart by calculation of the stiffness constant of the myocardium; no significant changes occurred in WKY; (3) reversal of myocardial fibrosis was accompanied by an increase (P < .025) in myocardial matrix metalloproteinase 1 activity determined by degradation of [14C]collagen with myocardial tissue extracts after trypsin activation of myocardial promatrix metalloproteinase 1; matrix metalloproteinase 1 activity remained unchanged in WKY treated with lisinopril; and (4) systolic dysfunction, measured by a significantly (P < .025) diminished slope of the systolic stress-strain relation under isovolumic conditions of the left ventricle, was found in 110-week-old SHR, and it could be prevented by lisinopril treatment. "
5.	Pancreatic Neoplasms (Pancreatic Cancer) 09/01/1989 - "The original test used by Halliday and Miller was modified by substituting tissue extracts with purified tumor antigens (gastrointestinal cancer antigen [GICA]) with the aim of reducing false-positive results in the diagnosis of patients with early pancreatic cancer. " 01/01/1990 - "Identification of the peanut-agglutinin binding pancreatic cancer serum marker in pancreatic tissue extracts."

Related Drugs and Biologics

1.	Antigens
2.	Tissue Inhibitor of Metalloproteinase-1
3.	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)
4.	Matrix Metalloproteinase 1 (Interstitial Collagenase)
5.	Trypsin
6.	Fibrin
7.	Insulin Receptor Substrate Proteins
8.	CA-19-9 Antigen (CA 19-9 Antigen)
9.	Lisinopril (Prinivil)
10.	Protein Kinase C

Related Therapies and Procedures

1.	Injections
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Cryosurgery
4.	Heterologous Transplantation (Xenotransplantation)
5.	Immunomodulation