Onychomycosis (Tinea Unguium)

09/01/2004 - "The accepted regimen for terbinafine, one of the most effective treatments for dermatophyte onychomycosis, is continuous administration of 250 mg/day over 16 weeks. "
12/01/2016 - "Daily practice: Mikailov and al., challenge our habits by their medico economic study and propose an empirical treatment with terbinafine for patients with suspected onychomycosis that is cost effective with minimal effect on patient safety as terbinafine-induced liver injury is very rare. "
10/01/2009 - "Terbinafine is an excellent choice in diabetics due to its low risk of drug-drug interaction and proven efficacy against the typical pathogens that cause onychomycosis. "
03/01/2004 - "This review suggests that terbinafine is a safe and effective treatment for onychomycosis in high-risk populations. "
11/01/1995 - "High mycologic cure rates in onychomycosis of the toenail can be achieved by terbinafine by this novel treatment regimen."

12/01/2012 - "The purpose of the present study was to design and evaluate the potential of microemulsion-based gel as colloidal carrier for itraconazole for delivery into onycholytic nails for effective treatment of onychomycosis. "
09/01/2005 - "Itraconazole may be effective in the treatment of onychomycosis caused by F. "
11/01/2003 - "Itraconazole was found to be effective, well-tolerated and safe therapy for disto-lateral subungual onychomycosis."
01/01/2000 - "Itraconazole is effective against Candida onychomycosis. "
04/01/1998 - "The broad spectrum of activity of itraconazole in vitro manifests itself clinically with the drug being effective for the treatment of onychomycosis caused by dermatophytes, Candida and some non-dermatophyte molds. "

09/01/2020 - "Efinaconazole was safe and efficacious in pediatric participants with mild-to-severe onychomycosis, with improved mycologic cure and complete cure rates compared with adults from two 52-week studies. "
02/01/2018 - "This post hoc analysis supports previous data showing good efficacy of efinaconazole in mild onychomycosis. "
07/01/2015 - "Our onychomycosis patients treated with efinaconazole might expect a 50% improvement in their disease within a year, and this will be seen as significant by many, especially those who have suffered for many years. "
05/06/2023 - "Overall, the promising results obtained here demonstrate the prospective of this non-invasive method for the effective transungual delivery of efinaconazole, which could improve the treatment of onychomycosis."
01/01/2022 - "Overall, efinaconazole is a safe and effective clinical option for the treatment and management of onychomycosis. "

10/01/1989 - "Even if the treatment period was short the good effect in the majority of the patients indicates that this solution is effective in topical treatment of onychomycosis."
12/01/2017 - "If onychomycosis was clinically suspected, nail samples were collected and direct microscopy with 15% KOH solution and culture were performed. "
10/01/1989 - "The good effect of this solution in the treatment of onychomycosis is in correlation with a good in vitro activity with MICs of 5% against Tr. "
10/01/2000 - "Data from the pivotal US trials have demonstrated that ciclopirox nail lacquer 8% topical solution is significantly more effective than placebo in the treatment of onychomycosis caused by Trichophyton rubrum, and of mild to moderate toe onychomycosis without lunula involvement. "
03/01/2022 - "Altogether, phase I and phase III clinical trials, and post-hoc analyses indicate that efinaconazole 10% topical solution is a safe and effective treatment for adult and pediatric onychomycosis, with a satisfactory mycological and clinical cure."

08/01/2021 - "Onychomycosis is difficult to treat, as the efficacy of most antifungal agents is relatively low. "
06/01/2015 - "The mechanisms of action of systemic and topical antifungal agents and devices effective against the most common dermatophyte and nondermatophyte causes of onychomycosis are discussed. "
01/01/2004 - "Antifungal agents are beneficial in the treatment of onychomycosis in the general population, as well as in children, the elderly, and immunocompromised individuals. "
02/15/2001 - "With careful monitoring, patients treated with the newer antifungal agents have a good chance of achieving relief from onychomycosis and its complications."
10/01/2017 - "Although systemic and topical antifungal agents are widely used to treat onychomycosis, oral medications can cause adverse effects and the efficacy of topical agents is not satisfying. "

03/01/2006 - "Congenital candidal onychomycoses: effective cure with ciclopirox olamine 8% nail lacquer."
09/01/1991 - "This study indicates that 8% ciclopirox olamine nail liquor, with its satisfactory efficacy and lack of side effects, is a good remedy for onychomycosis."
05/01/2002 - "It was concluded that ciclopirox 8% nail lacquer, which has recently become available in the larger size of 6.6 mL, is a cost-effective agent for the management of toenail onychomycosis."
08/01/2001 - "Ciclopirox nail lacquer is safe and effective for the topical treatment of onychomycosis in patients with diabetes and produced results similar to those observed in the general population."
02/01/2016 - "The results of this study, and of a previous pivotal study versus the insoluble formulation of ciclopirox 8%, led to consider P-3051 as the gold standard for the topical treatment of mild-to-moderate onychomycosis. "

05/01/2017 - "According to our meta-analysis, combination treatment of amorolfine 5% nail lacquer and systemic antifungals can result in higher percentage of complete clearance of onychomycosis. "
11/01/2014 - "Case of infantile onychomycosis successfully cured by 5% amorolfine nail lacquer."
05/01/2016 - "As onychomycosis is unsightly, this study clinically evaluated whether the antifungal efficacy of amorolfine 5% nail lacquer (NL) was affected by a masking, natural-coloured, cosmetic nail varnish applied 24 h later; in vitro investigations were also performed. "
05/01/2016 - "Application of cosmetic nail varnish does not affect the antifungal efficacy of amorolfine 5% nail lacquer in the treatment of distal subungual toenail onychomycosis: results of a randomised active-controlled study and in vitro assays."
08/01/2016 - "Efficacy of 5% amorolfine nail lacquer in Neoscytalidium dimidiatum onychomycosis."

02/01/1995 - "More than half of the cases with onychomycosis in their fingers showed improvement within four weeks and complete recovery within 20 weeks after the administration of fluconazole. "
06/01/1998 - "Preliminary clinical data suggest that fluconazole is effective in the treatment of patients with onychomycosis. "
05/01/1996 - "These results indicate that fluconazole should be effective in the treatment of onychomycosis in a dose of 150 mg once weekly. "
06/01/1998 - "Fluconazole administered once weekly is safe and effective in eradicating distal subungual onychomycosis of the fingernail caused by dermatophytes."
06/01/1998 - "Determinations of plasma and fingernail concentrations of fluconazole were performed as part of a larger study comparing the safety and efficacy of once-weekly fluconazole (150, 300, and 450 mg) to placebo in the treatment of distal subungual onychomycosis of the fingernails caused by dermatophytes. "

02/01/1987 - "To authenticate the advantage of the etiologic diagnosis of Tinea unguium by mycological studies, the promising result of our previous clinical therapeutic trial with Griseofulvin was presented."
04/14/1965 - "[Clinical and mycological studies of griseofulvin treated onychomycoses]."
01/15/2012 - "Therefore, the treatment of onychomycosis with griseofulvin seems futile. "
10/01/2004 - "Though griseofulvin was introduced in the late 1950s and was at the time the only Food and Drug Administration (FDA)-approved drug in the United States for the systemic treatment of onychomycosis, its cure rate seldom exceeds 40%. "
07/01/2003 - "Griseofulvin was the first significant oral agent available to manage onychomycosis. "

05/01/2023 - "Keratolytic properties of urea 40% have long time used for the treatment of onychomycosis. "
07/30/2020 - "Overall, the results support that TBH-urea-RLPO IFFS is an efficient and promising approach for onychomycosis targeting treatment."
05/01/2020 - "Urea occlusion prior to single session fractional CO2laser as a treatment in onychomycosis."
01/01/2019 - "Despite a theoretical basis for the use of urea for the treatment of onychomycosis, the evidence-base for this treatment has not been systematically reviewed. "
01/01/2019 - "The use of urea for the treatment of onychomycosis: a systematic review."

03/01/2021 - "The clinical cure for onychomycosis is extremely difficult and effective new antifungal therapy is needed.Hypothesis"
01/01/2005 - "The improved effectiveness and economic advantages of combined topical/oral therapies benefit both patients and health providers; these treatment regimens therefore have an important role to play in the modern management of onychomycosis."
02/01/2000 - "Aspergillus onychomycosis, on the other hand, responded very well to therapy and all our patients were cured after systemic or topical treatment. "
11/01/2006 - "Fifth toenail clinical response to systemic antifungal therapy is not a marker of successful therapy for other toenails with onychomycosis."
02/01/2015 - "Combination therapy using multiple drug classes may improve the overall efficacy of antifungal treatment in onychomycosis."

09/01/2020 - "Devices such as lasers have shown promise in improving the cosmetic appearance of the nail, but due to a high variation of study methods and definitions of cure, their effectiveness for onychomycosis has yet to be sufficiently proven. "
01/01/2020 - "Although laser treatment of onychomycosis has been proven to be effective in the clinic, the underlying mechanism of the effect of the laser on fungal growth is not clear. "
03/01/2017 - "Clear nail growth is an important treatment goal for patients; however, many do not realise that laser treatment is not a cure for onychomycosis. "
10/01/2019 - "The current level of evidence is limited and with high heterogeneity, making it difficult to assess the true efficacy of laser treatment for onychomycosis. "
01/01/2019 - "Long-pulsed Nd:YAG 1064-nm laser two-stage treatment was effective for onychomycosis, with significantly improved mycological clearance and clinical efficacy. "

02/01/2017 - "Q-switched Nd:YAG lasers with very short pulse durations and fractionated CO2 demonstrate the most promise for the treatment of onychomycosis. "
01/01/2017 - "Based on these results, long-pulsed Nd:YAG laser can be used as an effective treatment for onychomycosis, but further studies are needed to draw firmer conclusions."
01/01/2018 - "The Energy Density and Treatment Times Are the Main Factors That Affect the Efficacy of Long-Pulsed 1,064-nm Nd:YAG Laser Treatment for Onychomycosis Caused by Trichophyton rubrum."
04/01/2017 - "The promising results of our study identify long-pulsed 1064-nm Nd:YAG laser as a possible alternative option for the treatment of onychomycosis. "
05/01/2016 - "Long pulse 1064 nm Nd:YAG laser is an effective and safe approach for treatment of onychomycosis of the toenails."

01/01/2020 - "Fractional CO2 laser combined with topical antifungal is a safe and effective treatment for onychomycosis."
12/01/2019 - "Fractional CO2 laser is a safe and effective treatment modality for onychomycosis. "
05/01/2019 - "Fractional CO2 laser-assisted drug delivery is an effective and safe treatment option for onychomycosis."
01/01/2022 - "Efficacy of Fractional CO2 Laser in Onychomycosis: A Clinical Evaluation."
01/01/2022 - "In conclusion, fractional CO2 laser with topical antifungal could be a safe alternative treatment in patients with onychomycosis, who are difficult to take oral antifungals."

12/19/2022 - "According to the results of the clinical trials, laser therapy is effective for the treatment of onychomycosis, but the in vitro findings are inconsistent among studies. "
05/01/2017 - "Conclusion: Non-thermal laser therapy is safe and effective for increasing the extent of clear nail in onychomycosis-infected toenails following one weekly treatment for four weeks. "
11/01/2013 - "Laser therapy offers a safe and effective new option for onychomycosis. "
04/01/2012 - "Recently introduced laser therapy has shown to be a safe and effective treatment for onychomycosis. "
11/01/2019 - "The aim of this study was to evaluate the safety and efficacy of the treatment of onychomycosis with local laser therapy. "